Histopathologist ,speciality Onco ,at Nanavati Max . Happiness is family and the small things,interested in Indian history and temple architecture,art.
Horrible treatment (radiation) associated epithelial changes in duodenal mucosa. The p53 can be ignored, probably reflecting upregulation rather thana mutational event. The same can be seen in the stomach.
Hutchings DA, et al PMID: 36843539; PMCID: PMC10460459.
A study in Virchows Archiv examines the role of FOXL2 as an immunohistochemical marker in identifying ovotesticular cords in pediatric patients with ovotesticular disorders of sex development. Findings support its diagnostic utility.
https://t.co/Vhtk86gPk6
#PathQuiz 🔬🫁 #ThoracicPath
A) Mucoepidermoid Carcinoma
B) Papillary Adenocarcinoma
C) Sclerosing Pneumocytoma
D) Papillary Adenoma
#Pathology
Clue in caption 🧐
#PathQuiz 🔬 #Liver
A) Hepatocellular carcinoma
B) Gastrointestinal stromal tumor
C) PEComa (Angiomyolipoma)
D) Lipoma
#Pathology#GIPath
Clue in caption 🧐
Landslide! 🙌
The breast sample shows bland storiform spindle cell neoplasm in dense fibrous stroma, studded with dilated ‘staghorn’ vasculature—findings of solitary fibrous tumor (SFT).
SFT harbor NAB2::STAT6, caused by inversion of chr12.
#PathX#PathTwitter#breastpath
p53 IHC can help confirm a diagnosis of esophageal squamous dysplasia. In occasional HPV-associated cases, p16 staining is strongly reactive. This example is probably driven by a TP53 mutation. Don't expect the full thickness staining typical of glandular dysplasia.
Not everything is what it seems.
Middle-aged patient. Consult case. Minimal clinical data. Ileal resection for obstruction → tumor found.
Let’s follow the diagnostic trail. Short thread, do the polls in order (and no sneak peek...)