This project was a ton of fun to put together and wouldn’t have been possible without the tremendous efforts of this team. Check out our now-published cheminformatic platform for skeletal edit development prioritization below!
https://t.co/4ZVAjsFmC3
Congrats to @gloganb & collaborators @lucaskaras1 (@Sigman_Lab) & Reilly & @Charles_chem (Merck) on the publication of our work on a cheminformatic analysis of core-atom transformations in pharmaceutically relevant heteroaromatics in J. Med. Chem.
https://t.co/T3LqAnpSV0
Congrats to @gloganb, @SojungKim20, Yusuke and collaborators @BarnerKowollik, @GileadSciences, @Merck on our indazole to benzimidazole conversion https://t.co/qiry103DEp coordinated with @LeonoriLab https://t.co/Jugs3Nm4aY
Our study detailing indazole-to-benzimidazole phototransposition is out now in @angew_chem together with related work from @LeonoriLab!
This has been a fun project to lead, and it’s been my privilege to work with this awesome team. Read below! (1/2)
https://t.co/H9VQewlqqY
To round out our work on these photomediated ring contractions of saturated heterocycles, I'm excited to share this collaborative story about uncovering interesting enantioselectivity trends in this system, out now in @J_A_C_S!
The final chapter of my PhD with @SarpongGroup at @UCB_Chemistry is published! Check out our full story of how we approached the synthesis of Daphniphyllum alkaloids inspired by molecular complexity scoring, out now in @J_A_C_S 🎉 https://t.co/BfoKhIqL26
We’re excited to share our quantitative assessment of the potential impact of skeletal edits, now on ChemRxiv! This cheminformatic platform was developed with @lucaskaras1 from @Sigman_Lab and Reilly Eason & @Charles_chem at #MerckChemistry.
https://t.co/8U3mqcQ0PC
Ever thought about quantifying molecular complexity? We wrote a Perspective on how modeling this fascinating concept can lead to new insights in synthetic chemistry. Check it out in @NatRevChem! 🎉
@SarpongGroup
https://t.co/LIlqiI1cuf
My total synthesis of baphicacanthcusine A is out now in @angew_chem. It has been a fascinating journey learning about these unique molecules and I’m really proud to tell this story! https://t.co/R5eElTDEai
Our investigation into the photomediated ring contraction of saturated heterocycles is out in @J_A_C_S! Excited to finally share my inaugural 1st author, multi-part story that blends synthesis, mechanistic & wavelength-dependent insight, and computations.
https://t.co/dVqUQxcmyS
F*** it. Using "editing" in the title of my next paper.
Suzuki Rxn? Editing via C-C Bond Formation and Halogen/Boron Deletion.
3+2? Editing via strategic rearrangement of electrons to form a cycle.
Dearomatization of Pyridinium? Editing via the removal of aromaticity.
Congrats to @gloganb , @SamLKraus and our collaborators at #Merckchemistry and the @Sigman_Lab on the publication of our work on 14N to 15N exchange in azines in JACS!
https://t.co/RDY3KMqlaE
Fourth year @gloganb, placed 2nd in the poster session for his great poster on his
recent 14N-to-15N skeletal edit of nitrogen heteroaromatics work. Congrats Logan! We’re so proud of you! 5/5
15N Incorporation into pyridines via NTf-Zincke imine intermediates now on @ChemRxiv . Congrats to Hillary, David, Marie, Kaila, and Jeff from my lab: https://t.co/0rIJ8Mx8fH
See related work from @SarpongGroup@Sigman_Lab/ Smith/Feuillastre-Audisio
Grateful to have been a part of this awesome team and work with #MerckChemistry and the @Sigman_Lab! Excited to share my new first author paper on an isotopic labeling strategy for nitrogen heteroaromatics using skeletal editing. Check it out on ChemRxiv: https://t.co/RziYdjnyYk.