Team GOBT

Genomics and Oncogenesis of pediatric Brain Tumors lab @GustaveRoussy @Inserm
Dedicated to understanding & defeating pediatric brain cancer

[Team GOBT @GOBT_Team]

Call for applications still open

[Marco Bruschi @MarcoBruschi10]

⏰
The @GOBT_Team in #GustaveRoussy is hiring a graduate lab engineer to develop and characterize brain organoids derived from pediatric patients with genetic predispositions to cerebral tumors.
If you know candidates who might be interested, please share. Details are attached.

[Marco Bruschi @MarcoBruschi10]

⏰
The @GOBT_Team in #GustaveRoussy is hiring a graduate lab engineer to develop and characterize brain organoids derived from pediatric patients with genetic predispositions to cerebral tumors.
If you know candidates who might be interested, please share. Details are attached.

[Marco Bruschi @MarcoBruschi10]

Here we are, the #CSOrganoids2024 symposium organized by @CellStemCell in the beautiful #SanDiego.
Remarkable ongoing improvement of existing #organoid models to understand development & disease and a lot of mechanobiology. We add some #pediatriconcology research to the topics.

[Castel David @CastelDavid_Fr]

Great time and discussions at the ChadTough Defeat DIPG Research Workshop in Ann Arbor.
Big thanks to Sriram @VennettiLab, Carl @CarlKoschmann and @ChadTough for the kind invitation to talk there.

[Team GOBT @GOBT_Team]

📣 📣 French brain tumor community:
Tomorrow (March 12th) Dr Jacques Grill will be giving a webinar over the current challenges associated with #DMG / #DIPG.
Looking forward to see you all tomorrow, 6pm CET! (link below) 😉
https://t.co/3AMyntwSEJ

[Marco Bruschi @MarcoBruschi10]

Glad to see that our article on invasion and metastasis in #DMG /#DIPG made the cover of this month's @NeuroOnc issue!
Grateful to the @GOBT_Team and our terrific collabs, to @canceropole and, most of all, to patients and their families. @GustaveRoussy
https://t.co/xbjSt2X5Ss

[Castel David @CastelDavid_Fr]

Very proud that the work by @MarcoBruschi10 in our @GOBT_Team on #DMG invasion made it to the cover of @NeuOnc this month together with an editorial by Stephen C Mack !

https://t.co/VKUYgy8lR3

[Team GOBT @GOBT_Team]

@WeKeepFighting #DIPG / #DMG

[Castel David @CastelDavid_Fr]

Very proud that the work by @MarcoBruschi10 in our @GOBT_Team on #DMG invasion made it to the cover of @NeuOnc this month together with an editorial by Stephen C Mack !

https://t.co/VKUYgy8lR3

[Team GOBT @GOBT_Team]

#WeKeepFighting #DMG #DIPG

[Gustave Roussy @GustaveRoussy]

La guérison de Lucas, d'un cancer réputé incurable est une grande piste d’espoir sur laquelle travaillent avec détermination @GustaveRoussy, grâce au soutien historique et majeur d’@ImagineforMargo et de la campagne #GuerirLeCancerDeLenfantAu21eSiecle. 👇
https://t.co/LkMsnV2q6B

[Team GOBT @GOBT_Team]

#WeKeepFighting #DMG

[Imagine for Margo @ImagineforMargo]

Le Gliome infiltrant du tronc cérébral est un #cancer au pronostic très sombre. Grâce à l’essai BIOMEDE, mené par le Dr. Jacques Grill (@GustaveRoussy) & financé par @ImagineforMargo, 8 enfants sont ajd long survivants. Une première mondiale !
+ d’infos 👉 https://t.co/ve6ERVRtrK

[Johannes Gojo @gojojohannes]

I am honored that our project was selected!!! Big thank you to everyone making this possible @NBTStweets @CERNfoundation
Within a great team together with @FilbinMariella @LoetschD @WalterBerger19 we seek to find better treatments for high-risk ependymoma #epENDymoma

[Castel David @CastelDavid_Fr]

Very pleased to share work from @Lucie_Auffret in our @TeamGOBT on the identification of a new subgroup of #DMG H3 K27 and MAPK co-altered published in Acta Neuropathologica.
https://t.co/nu1x538Feb

[Team GOBT @GOBT_Team]

Lors d'une superbe soirée festive dans l'église du Pentemont, l'association @EnfantsCancersa officialisé son soutien à notre projet de recherche sur le #CMMRD en remettant un chèque à @MarcoBruschi10. Ce financement servira à mettre en place des modèles d'étude innovants. Merci!

[Team GOBT @GOBT_Team]

Bravo et MERCI à l'association "La Marche de l'Ecureuil" pour votre superbe mobilisation au profit de la recherche sur les #gliomesinfiltrants #GITC #DIPG.
Grâce à vous 24.744,52 € ont été reversés au service de recherche dirigé par le Dr J. Grill.
#EnsembleOnEstPlusFort

[Team GOBT @GOBT_Team]

5/ Huge congratulations to our @vinoushka_ @ThomasKergrohen @MarieDebily and all the other authors and collabs!

[Team GOBT @GOBT_Team]

Our work on the role of #VRK3 in supporting #DMG/#DIPG cell fitness and as a targetable tumor vulnerability is finally out on @FrontOncology!
Thanks to @letoiledemartin @LISAFOREVERlisa @ImagineforMargo and to all our supporters!
https://t.co/HxeK0Ybupt

[Team GOBT @GOBT_Team]

4/ Overall, these data clearly reinforce the interest of VRK proteins as therapeutic targets in cancers from nervous system and in particular of VRK3 in DMG

[Team GOBT @GOBT_Team]

3/ Moreover, we demonstrate that #DMG-H3K27M cell fitness depends on oxidative phosphorylation.
Indeed, VRK3 depletion upregulates oxidative phosphorylation related genes in DMG-derived GSC.
https://t.co/7ZnPiyHc3P

[Team GOBT @GOBT_Team]

2/ We show that knockdown of VRK3 impairs DMG-K27M proliferation, being responsible of a G1 cell-cycle arrest.
https://t.co/Hq2Hb4Jaa2

[Team GOBT @GOBT_Team]

@MaraVinci2 @MarcoBruschi10 @IlonLiu @Fondationfrance @canceropole @NeuroOnc Thank you Mara!