Gönenç Aksu

Curing the Pain of Love @niluferbio | "This should have been the golden age of biotech." | Free Markets. Free Speech. Freedom from Regulation. | Nusayri-Alawite

[Gönenç Aksu @gonencaksu]

How techno-optimist am I? My name literally means abundance.

[Max Hodak @maxhodak_]

right now it doesn't matter if you're making an experimental drug for one very sick patient or mass manufacturing it for thousands: the manufacturing controls are the same, and this is the difference between $3M+ and <$50K manufacturing costs

[Gönenç Aksu @gonencaksu]

@elonmusk you can only hope if ai slowdowns @spacexai might catch up.

[Gönenç Aksu @gonencaksu]

music analogy is idiotic.

music became effectively infinite because once a song is created, the marginal cost of distributing another copy is essentially zero.

healthcare is moving in exactly the opposite direction. gene therapies, cell therapies, require individualized manufacturing, complex CMC, logistics, and quality control.

about 100k new music tracks released to streaming services per day.

yet only 50 NCEs per year gets approved per year. 50% of them is for orphan indications.

the analogy ignores the realities of the distribution and discovery of biological goods.

[Gönenç Aksu @gonencaksu]

@brian_armstrong it doesn’t solve the underlying problem. If you need to have a software godfather just to repurpose a drug for your own disease the world is cooked.

we need more capital and better aptitude for risk in the life sciences industry.

[Gönenç Aksu @gonencaksu]

@ladanuzhna Chronic mAb use doesn’t interfere with intracellular PCSK9.

But its full knockout in hepatocytes means more CD36 on cell surfaces = more fatty acid uptake.

It will overload liver metabolism.

I’d bet they don’t even have an endpoint to measure fibrosis.

[Gönenç Aksu @gonencaksu]

@elonmusk @grok any vacation plans for next year?

[Gönenç Aksu @gonencaksu]

@citrini next, convince @PraxisMedicines to run a visual snow syndrome trial with ulixicaltamide. it’s basically same pathology but sensory

[Gönenç Aksu @gonencaksu]

an $AZN executive just said 2070 is his AGI timeline, and it was out of context, lmao

[Gönenç Aksu @gonencaksu]

@LongmireMD @brian_armstrong @medableinc Decentralized trials are still massively underutilized. But the real time constraint is CMC.

[Gönenç Aksu @gonencaksu]

@brian_armstrong currently working on ectogenesis, building a way to manipulate trophoblast and epithelial cells to build something close to Avian CAM for optimal oxygen exchange. That’s the current bottleneck right now, placenta is useless ex vivo. feel free to reach out if you are interested.

[Gönenç Aksu @gonencaksu]

Later on, during the Holocaust, Turkey deported about 2,500 Jews of Turkish origin to Auschwitz and Sobibor extermination camps.

Thousands of Jews, entire families, living abroad had their citizenships revoked or denied re-entry, making them unable to escape Nazi Germany.

Those remaining were subjected to 175% wealth tax, forcing them to sell properties and businesses far below market value.

Many had to abandon Turkey and the homes where they had lived for generations.

[L.H. Grey @Grey_0G]

NEVER FUCKING FORGET WILLIAM F. BUCKLEY.

This wasn’t some desk-jockey spook.

This was a battle-hardened CIA Station Chief in Beirut...a Green Beret legend who walked into that blood-soaked shithole in 1984 after the Iranian-backed Hezbollah suicide truck bomb vaporized our embassy and slaughtered dozens of Americans.

Buckley’s mission: rebuild the entire intel network those raghead savages had just gutted.

He knew the risk.

He went anyway.

On March 16, 1984, Hezbollah gunmen snatched him off a Beirut street like the gutless cowards they are.

Iranian Revolutionary Guard and Hezbollah muscle...directed straight from Tehran..:took over.

For the next 15 months.

444 days.

They didn’t just kidnap him.

They waged a sadistic, systematic war on his body, mind, and soul.

Coffin-sized cell.

Blindfolded.

Shackled 24/7.

Starved.

Sleep-deprived.

Pumped full of drugs and hallucinogens through puncture marks that still showed on the autopsy.

Beaten methodically...one punch to the gut, one kick to the head at a time...until his organs were mush.

That psychotic Hezbollah “psychiatrist” Aziz al-Abub and his Iranian handlers turned it into an art form: psychological rape designed to shatter the strongest will on earth.

They wanted every name, every asset, every operation.

They got 400 pages of confessions and over 200-300 CIA sources burned.

Many of those patriots were hunted down and executed because this hero broke under torture no human should ever endure.

Other hostages heard him through thin walls...retching, coughing up blood, hallucinating hot cakes and syrup in his delirium.

Hezbollah sent the CIA three videos, each one showing him more destroyed than the last.

A once-iron warrior reduced to a gaunt, drooling shell.

They denied him medical care on purpose.

Pneumonia set in.

His heart finally gave out on June 3, 1985...tortured to death by animals who get hard breaking Americans because their death-cult “religion” tells them it’s holy.

His body?

Dumped like garbage on a Beirut roadside years later, wrapped in bandages and ropes, catheter still in from whatever fresh hell they inflicted at the end.

This is what Iranian-backed Hezbollah does.

This is their psychology: not random cruelty, but calculated soul-murder to humiliate America, prove jihadist savagery beats Western strength, and send a message..."we own you.”

Same playbook as the 1983 Marine barracks bombing that murdered 241 of our brothers.

Same as Colonel William Higgins, hung and mutilated.

Same mullah death cult that’s been at war with us since 1979.

Imad Mughniyeh, the mastermind behind Buckley’s nightmare?

Got vaporized by a CIA drone years later.

Good.

As OPERATION EPIC FURY lights up Iranian nuclear sites and leadership like the Fourth of July from hell, remember Buckley’s broken body and unyielding spirit.

Every Hellfire, every bunker-buster, every dead IRGC commander is payback for this man.

He died so we would never forget.

Those motherfuckers started this war.

We’re finishing it.

Lethal. Precise. Total.

💀

[Gönenç Aksu @gonencaksu]

@josiezayner It depends on the explainer. If you can explain through first principles, even people without basic biology knowledge understand it.

[Crémieux @cremieuxrecueil]

The usage of a racially inappropriate character in this picture genuinely had me confused for a moment

In reality, there are almost zero White child brides. The practice is so rare in White countries that no one collects the data

They should've used a more representative image:

[Gönenç Aksu @gonencaksu]

@airkatakana It’s been 9 years for me. She once said “he’s the person who’s loved me the longest.”
Still unrequited.
From my side it feels like survivorship bias.
Any advice beyond just waiting longer?

[Gene Smith @GeneSmi96946389]

In ten years, Israel almost got rid of cystic fibrosis among newborns. How did they do it?

[Bill Ackman @BillAckman]

.@Harvard after 12,000 Iranian protesters assassinated.

[Rapid Response 47 @RapidResponse47]

Introducing The New Pyramid

https://t.co/lGnNsgwSgF

[JD Vance @JDVance]

Absolutely insane headline

[Gönenç Aksu @gonencaksu]

@ruslanjabari drugs for unrequited love