@Milajoy@TheJusticeDept Sorry, been told this for years and nothing but lip service has happened. I'll believe only when I see prior leaders perp walked into court and then to prison.
@ScottPresler Start with Senator John Thune. His delays and refusal to allow Trump to pass recess appointments via Thune's faked senate sessions should disqualify him from the Republican party.
@TraderStrider MI has become too crazy for America loving engineers to move there. How about opening an office in NH, TX, FL or allowing working remotely full time? There are plenty of US software engineers.
@jaredctate Love it, want to use it, but I don't have resources to run a node in order to do it. Hopefully the Atomic wallet and similar wallets will support this soon!! :-)
@LeaderJohnThune You are a failure of a leader that has been blocking the agenda that most Americans voted for. Pass the SAVE act and the Clarity act ASAP!!!
@EleanorTerrett@Sen_Alsobrooks@berniemoreno Who would have guessed that Dems would find a problem with the text accepted by the President and Republicans?? So surprising ... not!
I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod@friedberg@chamath@pesottas
Nordic countries are not examples that socialism works, they are not socialistic countries.
It was proven that socialism doesn’t work and abandoned the policies of socialism.
They are capitalistic with a free market economy.
Yann LeCun just told the most well-funded industry in human history it is solving the wrong problem.
LeCun: “Babies learn this around the age of eight or nine months, that objects don’t float, they fall.”
No dataset. No labels. No reward signal.
A nine month old drops a spoon and builds a physics engine no machine can match.
LeCun: “Most of us can learn to drive in about 20 or 30 hours of training without ever crashing, causing any accident.”
Twenty hours.
Tesla has built the most capable driving system on the road. It took billions of miles of data to get there. A sixteen year old gets there over a long weekend.
Not because the teenager is the better driver.
Because the teenager is not learning to drive. They are deploying a model of reality they have been building since birth.
LeCun: “If we drive next to a cliff, we know that if we turn the wheel to the right, the car is going to run off the cliff and nothing good is going to come out of this.”
You simulate the crash. You see the wreckage. You feel the fall. You turn the wheel.
None of it was real. All of it was intelligence.
Every AI has to crash a thousand times to learn what you imagined once and never did.
That is not a performance gap. That is an architecture gap.
LeCun: “The main problem we need to solve is how do we learn models of the world.”
Not bigger models. Not more compute. Not another trillion tokens.
World models. A machine that can run reality forward before it acts.
The industry is scaling language.
LeCun says language is a compression of thought. Not thought itself.
You understood gravity before you could say the word.
You grasped cause and effect before your first sentence.
The deepest intelligence you will ever possess was built in total silence.
And every lab on Earth is trying to reconstruct the mind from words alone.
Physics does not care about your context window.
A baby who learns that cups fall in a kitchen already knows that rocks fall off cliffs. No retraining. No fine-tuning. One model. Every environment.
That is what intelligence actually is.
Not prediction. Not pattern matching. Not scale.
A simulation of reality so precise you rehearse the future before it exists.
Every infant on Earth builds one.
No machine ever has.
🚨 OOPS… Amy Coney Barrett and John Roberts NEED to hear this.
A constitutional expert argues that Supreme Court justices can face impeachment by the President and Congress over alleged CORRUPTION or ABUSE OF CONSTITUTIONAL DUTY.
Listen carefully!
W.H.G