Phil Hufton

As with most folks on social media, views are probably not my own

[Phil Hufton @gruftyhufty]

@elonmusknews30 A

[Caroline Lucas @CarolineLucas]

Why isn’t this headline news? The implications are horrifying … https://t.co/oji3PT6mhX

[NIPPY by Breas @NippyVentilator]

Breas UK are running some #AirwayClearance Study Days in 2025, with some fantastic speakers lined up. The first confirmed dates are Edinburgh (18th Oct), and Birmingham (29th Nov). Click here to sign up🙂

https://t.co/G8SYk5SOX4

#Clearo #IPPB #MIE #LVR #respisbest @TheACPRC

[Dr Mine Conkbayir MBE @MineEYMind]

Huge thanks to Chris Packham CBE for supporting our campaign to get @Ofstednews to remove/amend its discriminatory remarks about autistic children being "more likely to develop special interests" & "can therefore be drawn into extremism" in its teacher training document.

[Phil Hufton @gruftyhufty]

Anyone know where we could get a small amount of Polyox fake sputum for some testing?

[Alfredo Pachas @AlfredoPachasMD]

🔥🔥🔬 New Research Insight: Maintaining Ciliary Airway Clearance Requires 30-62% Functioning Cells 🧬

🌟 Key Takeaway: A recent study demonstrates that only 30-62% of functioning multiciliated airway cells (MCCs) is sufficient to maintain effective ciliary clearance in the lungs.

👨‍⚕️ Study Overview: Researchers used advanced lab techniques (immunofluorescence and in vitro assays) to examine the role of MCCs in maintaining airway health. By studying healthy individuals and patients with primary ciliary dyskinesia (#PCD), they measured the threshold of cell function required for airway clearance.

🕵️‍♂️Main Findings:
✅ Healthy subjects: Showed normal ciliary clearance with fully functioning MCCs.
❌ #Male #PCD patients: Demonstrated zero clearance due to defective cilia.
♀️ Female carriers: Retained partial clearance function, thanks to random X-chromosome inactivation.

💡 Why It Matters:
This discovery may guide new treatments for respiratory diseases like PCD, where ciliary function is impaired. Understanding the minimum required MCC activity could lead to better management and diagnostic approaches.

📊 Implications for Healthcare:
✅Threshold for Lung Function: Identifying the minimal percentage of functional MCCs can help in early diagnosis.
✅Gender Differences: Notable differences in ciliary clearance between male patients and female carriers offer new insights into X-linked genetic disorders.
✅Future Studies: 🧪 Calls for larger cohorts to further validate these findings and explore environmental influences like pollution or chronic inflammation.

⛔️Limitations and Bias:
🔻Sampling bias: The sample size is relatively small, particularly in the in vivo segment, which may limit generalizability. Larger cohorts could provide a more accurate reflection of the population variance in MCC functionality.
🔻Confounding Factors: Potential confounders include environmental factors that might influence ciliary clearance, such as airway inflammation or exposure to pollutants, which were not fully accounted for.
🔻Technical Challenges: The study relies heavily on sophisticated lab techniques, which could introduce variability depending on technical precision (e.g., immunofluorescence staining and ciliary motion analysis).

📈 Next Steps:
More extensive, more diverse studies are needed to confirm these thresholds and investigate the potential therapeutic applications for maintaining or restoring ciliary function in the airway.

▶️https://t.co/GpCmN6xfdi

@Shoemelia

[Phil Hufton @gruftyhufty]

@mylegoman saw this in @hotelindigo in Stratford upon Avon and thought if you…

[Breas Medical @BreasMedical]

🗓️ New webinar out on March 28th!
Topic: The use of Mechanical Insufflation-Excsufflation (M I-E) in children; common questions & answers.
Speaker: Dr Michelle Chatwin.
Register for full access: https://t.co/hCxxMc9olu
hashtag#educationbybreas #breas #airwayclearance #webinar

[Holly K (SHE/HER) 🏳️‍🌈🏳️‍🌈 @HollyRistell]

Check out this amazing fully funded resp CPD course for internationally educated physios!

@TheACPRC @thecsp

⬇️⬇️⬇️⬇️⬇️🫁💨

[Phil Hufton @gruftyhufty]

@USAinUK I believe the @WomensInstitute has extensively and conclusively researched and published the correct way to make a cup of tea

[Jodi Allen @JodiAllenSLT]

The perfect @mndeducation training event for community #SLTs wanting to expand their #knowledge #assessment & #management of #cough & #secretion management in #MND:

https://t.co/ihBbJ2f7Yd

Come join the #MDT teaching day:

🤗 NEWCASTLE 7th November

🤗 LONDON 21st November

[Ruth💙🫁 Respiratory Physio @respphysio]

Are any of my #respiratory #physiotherapy colleagues in Stroud or the surrounds for a private respiratory patient? Must be experienced!!!!
Please send a DM if you can help
Many thanks

[jefbroers @jefbroers]

Thanks a lot ⁦⁦@TiinaAndersen ⁦@michellechatwin⁩ @britthov. Great airway clearance days for the Nordics. All experts in one room, how lucky can the audience be. #educationbybreas #AirwayClearence #Clearway2

[Neeraj Shah @Neeraj0588]

Pleased to share our newest output -

Managing the patient with neuromuscular respiratory failure.

https://t.co/geK0v0uuFh

@DrPBMurphy @LaneFoxResearch @GSTTresearch

[NHS Million @NHSMillion]

The strikes this week have not been caused by doctors

They’ve been caused by a Government that has taken healthcare professionals for granted for far too long

Please RT if you can see through the Government spin and back the doctors

All they want is fair pay

[Phil Hufton @gruftyhufty]

@IKEAUK thanks for sending through the complete set of parts required to build the Hermes day bed my wife had to order in store after ikea failed to send through the order I placed on line Unfortunately it is not complete 5 bits misssing, guess which 5 bits I really need?

[jefbroers @jefbroers]

Great lectures on OHS & COPD during the Nordic ventilation days by ⁦@DrPBMurphy⁩ #educationbybreas #COPD #OHS

[NIPPY by Breas @NippyVentilator]

Only 3 more days to go until our next webinar...don't forget to sign up🙂

https://t.co/LxJn4FHgCZ

#LTV #longtermventilation #paediatrics #Nippy4+

[jefbroers @jefbroers]

2 days left to sign up for this  FREE webinar: https://t.co/KGq7QRWQlQ

Ruth Wakeman has many years of experience in this field and will share her team’s experience, so if you often take care of ventilated children, don't miss it! #educationbybreas #children #home #IV #NIV

[Project Fizzyo @FizzyoCF]

Editorial in ERJ: https://t.co/rQBLx4dSk4

"Airway clearance techniques in cystic fibrosis, while important, have been marked with few evidence-based trials. A recent study in ERJ is one of the first to show evidence & importance of quality of ACT in achieving clinical outcomes"