Greg Arabatzis

Expert Scaling Early Stage Ingredient And Product Companies In The Functional Medicine Industry

[Harshi Peiris, Ph.D. @Neuroscope_mp]

🚨 BREAKING:
Parkinson's disease may begin in your GUT — not your brain.

Peer-reviewed science now shows gut changes can precede motor symptoms by 10–20 YEARS.

And a deficiency in specific B vitamins may be driving the damage.
Thread 🧵👇

[Boston Radio Watch®️ @bostonradio]

22 years ago today, May 24, 2004, the Sopranos cast members presented David Letterman’s Top 10 category - “Things Never Before Said On The Sopranos”.

“I Just Whacked Myself”.

[William A. Wallace, Ph.D. @WilliamWallace]

Apple cider vinegar has built an entire wellness category on a real effect attributed to the wrong ingredient. The glucose-lowering data is genuine. The apple has nothing to do with it.

The acetic acid is what does the work, and any vinegar at the same concentration produces the same effect.

The original Johnston et al. study (Diabetes Care 2004) gave insulin-resistant and type 2 diabetic adults a vinegar drink before a meal containing 87 g of carbohydrates and saw postprandial glucose drop 64% in the insulin-resistant group and 19% in the diabetic group. The sample was small (n=29 crossover) but the effect size was large.

Ostman et al. (Eur J Clin Nutr 2005) ran the dose-response experiment. They served white bread with vinegar at three levels of acetic acid (18, 23, and 28 mmol) to healthy adults. Both glucose and insulin responses fell as acetic acid content rose. The effect tracked the acetic acid content, not the vinegar volume.

The 2017 meta-analysis by Shishehbor et al. (Diabetes Res Clin Pract) pooled the controlled trials. Vinegar consumption with a meal reduced postprandial glucose AUC (SMD -0.60, 95% CI -1.08 to -0.11) and insulin AUC (SMD -1.30, 95% CI -1.98 to -0.62). The effect is consistent and the magnitude is meaningful.

The mechanism is well-characterized. Liljeberg and Bjorck (Eur J Clin Nutr 1998) showed in healthy adults that adding vinegar to a starch meal delayed gastric emptying and that this delay tracked with the improved glycemic response. Slower emptying means slower carbohydrate delivery to the small intestine, which flattens the glucose curve. A secondary mechanism is inhibition of disaccharidase activity by acetate at the brush border. Neither depends on the source of the acetic acid.

The longer-term data is much weaker. Johnston et al. (Food Funct 2020) ran an 8-week trial of daily red wine vinegar in 45 adults at risk for metabolic complications. Fasting glucose and insulin sensitivity improved significantly, but body mass, waist circumference, and visceral fat did not change. The viral "ACV for weight loss" claim has thin support.

Two practical implications. First, if you want the postprandial effect, you need liquid vinegar at roughly 1 to 2 tablespoons. The dose has to deliver around 750 to 1500 mg of acetic acid. White, red wine, rice, and apple cider vinegars all work. Second, the gummies and tablets are a problem. Johnston et al. (J Nutr Metab 2022) tested commercial vinegar tablets head-to-head against liquid vinegar and found the tablets failed to lower postprandial glucose to the same degree.

The mother, the fermentation, the apple, the brand. None of it is the active ingredient. The acetic acid is.

Johnston et al., Diabetes Care 2004 · Liljeberg and Bjorck, Eur J Clin Nutr 1998 · Ostman et al., Eur J Clin Nutr 2005 · Shishehbor et al., Diabetes Res Clin Pract 2017 · Johnston et al., Food Funct 2020 · Johnston et al., J Nutr Metab 2022

[Dan Bartels @DanBartels2]

We’ve reached Memorial Day, Mets fans.

What’s your overall level of concern?

[BucciOT.Com @Buccigross]

Joke.

[SupplySide @SupplySide]

The merging of ancient ayurveda with quantum science creates supplements that deliver molecules tuned to the body's natural frequencies for lower doses with greater efficacy.

Learn how Greenspace Herbs does it.
https://t.co/QAqhjaV8rY

#QuantumAyurveda #Paid

[Dr. P@Indiamusings, PhD @indiamusings]

Excellent analysis: fair👇👍👇

Ayurveda can take quantum leap, if India has solid science based approval products with labeling of what it is for, what it does, and what it does not. Ayurveda products reduction process must be scrutinized & certified regularly by regulators 👌👍

[Greg Arabatzis @gtbara]

With UConn's loss to Marquette, St. John's has clinched the outright regular-season Big East title

It's the first time St. John's has won back-to-back outright Big East regular-season championships in program history

[Greg Arabatzis @gtbara]

Congratulations to @SamDarrnold on your remarkable Super Bowl win.

[SleeperMets @SleeperMets]

BREAKING:

Francisco Lindor will not be playing for Team Puerto Rico in the World Baseball Classic after having a cleanup procedure on his right elbow this offseason.

[Greg Arabatzis @gtbara]

WINTER SOLSTICE
It's the day of the year with the shortest period of daylight (9 hours, 15 minutes and 16 seconds in New York City) and the lowest sun angle (longest shadows).

[SNY Mets @SNY_Mets]

"If you had asked me three days ago, I thought this was a huge priority for the Mets...I'm not as optimistic now as I was then. I don't know that they're willing to go the years that Pete is going to require.

I hate to say it, but I'm not confident that Pete is going to be a Met."

- @Todd_Zeile with @SteveGelbs on Pete Alonso's free agency

[SNY Mets @SNY_Mets]

"What's coming next is probably a lot of really interesting, exciting things that's going to reset the roster. David Stearns has the chance to make this a very different team.

There's so much money out there to spend now with these players gone, and there's so much ambition that the Mets have to win.

Today is probably the hardest day in this transition into a new kind of Mets."

- @martinonyc on Pete Alonso's departure

[Greg Arabatzis @gtbara]

“That soft autumnal time, the woodland foliage now is gathered by the wild November blast.”

[Nick Penny @oppotacop]

The Polo Grounds during the 1905 World Series between the New York Giants and Philadelphia Athletics… complete with no outfield wall and horse drawn carriages.

[Greg Arabatzis @gtbara]

Thrilled to announce a collaboration between baseballs great Todd Zeile, John Salerno and myself on Infield Recovery Supplement Line. Please visit https://t.co/nTRVnUSecr to learn more

[Dustin @DustinSaracini]

Vladdy is Blue Jays Twitter. Yesavage gets another future Hall of Famer to roll over. 6 outs to get.

[Greg Arabatzis @gtbara]

Building incredible momentum with Oksana Lada Wellness and supplement line.

Please visit https://t.co/Vbn5Hq40if to learn more.

[Greg Arabatzis @gtbara]

What an incredible honor meeting Hollywood legend Ann Margaret.

[Greg Arabatzis @gtbara]

Had an incredibly productive Supply Side Global. Even Ran Into Willie Wonka.