HEALTHY GUT INITIATIVE

Passionate about Gut Health, Knowledge seeker, Working for a social cause “GUT HEALTH FOR ALL” #healthygutinitiative.

[iAGNi - Ayurveda Gastroenterology and Nutrition @IagniN]

Expanding the Scope of Ama: A Systems Biology Framework for ... : Journal of Research in Ayurvedic Sciences https://t.co/ddTkXy7UtN

#systembiology #ayurvedabiology #ayurveda
@ajitkolatkar @moayush @CCRAS_MoAyush

[Indian Journal of Gastroenterology @IJG_Journal]

A single test strategy using spot fecal bile acid test may be a feasible strategy for the diagnosis of bile acid malabsorption

Team @aiims_newdelhi

https://t.co/lCu9R0p7eY

[Ajit Kolatkar @ajitkolatkar]

March is colon cancer awareness month.

#coloncancer #MedTwitter

[Ajit Kolatkar @ajitkolatkar]

#Realworld impact:

Many patients can’t stop PPIs.
study supports double site #BIOHIT HPQT RUT as a practical tool in such settings with a very high diagnostic accuracy.
#gastrolabindia

[Ajit Kolatkar @ajitkolatkar]

PCR is gold standard, not affected by PPI.
•If PCR unavailable → Doublesite RUT is a cost-effective, quick, #pointofcare option.
•HPE reserved for patients needing cancer risk assessment (AG/IM staging).

[Ajit Kolatkar @ajitkolatkar]

📊 Study design: Prospective, 164 patients on PPI <2 weeks
✅• Double site RUT (antrum + body, #Biohit kit, #GastroLab India)
•Histopathology (Sydney protocol)
•PCR (cagA, cagE, vacAs1/2)
Gold standard = ≥2 positive tests.

[Ajit Kolatkar @ajitkolatkar]

🎯 Diagnostic Accuracy:
•Double site RUT(HPQT) : 94.5%
•HPE: 86.6%
✅ RUT(#Biohit #HPQT) had higher #sensitivity 89.13% & #specificity 96.61% compared to #histopathology.
#PCR still outperformed both.
#gastrolabindia #hpylori #gastroenterology #GITwitter #MedTwitter

[Ajit Kolatkar @ajitkolatkar]

🚨 New study alert!
How should we test for #Hpylori in patients already on #PPIs?
Though guidelines recommend stopping PPIs before testing, #realworld patients often can’t.
Study from PGIMER, India compares Double-site #BIOHIT RUT vs. Histopathology. 🧵
https://t.co/vmaSDYG1SQ

[Ajit Kolatkar @ajitkolatkar]

Like brain neurons gut cells found to “whisper”.

Research uncovers how gut communicates much like brain cells to directly influence intestinal stem cells.

Read more -

Telocytes deliver essential Wnts directly to murine intestinal stem ce... https://t.co/ebY7bjDeQi

[Ajit Kolatkar @ajitkolatkar]

@Singlamddm @krithivk @RakeshKalapala1 @miNitinjagtap Heartiest Congratulations

[Ajit Kolatkar @ajitkolatkar]

The body constantly fights allostatic load. Regulatory drift always precedes structural collapse. My latest essay maps the Functional Staging of Gastric Disease and its striking parallel to #Ayurveda’s Shatkriyakaal.
#Gastroenterology #SystemsBiology

https://t.co/oJK7m9sWHP

[Ajit Kolatkar @ajitkolatkar]

#Pepsin is secreted as inactive #pepsinogen. It activates only in strong acid at pH 1 to 3.

The system is tightly controlled.

#Digestion happens in the stomach.
Nowhere else.
(3/5)

[Ajit Kolatkar @ajitkolatkar]

Calprotectin 🟰What Neutrophils Release

Calprotectin (S100A8/A9) is released when neutrophils activate or undergo NETosis.
More neutrophils = higher fecal calprotectin = more active intestinal inflammation.
#Calprotectin #GITwitter #MedTwitter (4/8)

[Ajit Kolatkar @ajitkolatkar]

Launching “Gut & Beyond”
A long form blog on #gastroenterology, #Ayurveda, #systemsbiology, and clinical #reasoning.
Focused on patterns, function, and better questions rather than quick answers. Do read, share and subscribe if the areas interest you.

https://t.co/zlHG8s2bF6

[Ajit Kolatkar @ajitkolatkar]

#Reflux #PEPTEST

@peptest_reflux

[Ajit Kolatkar @ajitkolatkar]

#blogpost
Read through to know what this blog brings to the table…

#ayurvedabiology #systemsthinking #systembiology #Gastroenterology

https://t.co/ZOwYPu6wce

[Ajit Kolatkar @ajitkolatkar]

Pepsin is not inherently harmful.

Pathology begins when an evolutionarily digestive enzyme appears in the wrong location.

This shifts reflux from symptom driven thinking to biology driven reasoning. And this is what changes how we diagnose.

More in this #Peptest series (5/5)

[Ajit Kolatkar @ajitkolatkar]

Why #FecalCalprotectin Matters

Fecal calprotectin directly reflects:
• Mucosal inflammation
• Endoscopic severity
• Relapse risk
• Treatment response
It often rises before symptoms worsen.
#IBDMonitoring #GITwitter #MedTwitter (5/8)

[Ajit Kolatkar @ajitkolatkar]

#hpylori #AMR #microbialresistance #hpyloriresistance #systemdisruptor

https://t.co/e02eVcE8nu

[Ajit Kolatkar @ajitkolatkar]

#newblog

Check the latest blog

https://t.co/jAjaDwyLEm