I think we need to revisit the 48 hour rule before you can declare a person missing. A lot could happen in 48 hours!
The first hours after a person has not been seen or heard from are critical especially if there are clear indications that something is amiss.
@aproko_doctor Frame 1 is well understood, while frame 2 will need a professional or dictionary to understand which most people will not respond to not knowing the gravity of the ailment