Are you a clinician who sees patients with secondary polycythaemia?
Are you frustrated by the lack of an evidence base for treating these patients?
Does your practise differ from your colleagues when treating these patients?
Chromatin patterns 🧵
[1] How many times have you heard phrases like:
"Fine chromatin"
"Dotted like with a pencil"
"Smooth chromatin"
"Clumped chromatin"
"like a football (some of y'all may call it a soccer ball)"...?
What do they mean and how do you make sense of it all? How does the chromatin relate to the morphology? Let's take a deep dive. 👇
#OnlyCells #Chromatin #BackToBasics
@MorphologyAmigo@veraghali@NicoGagelmann Heard and read about plateletpharesis but have never had to do it, cytoreduction being the mainstay. Having said that I do know of a case where patient had a count of >3000 and resistant to max dose hydrea, pegasys and ruxolotinib…
Very pleased to able to share our latest research on platelet activation in #VITT authored by @richardbuka and @sam_310 from @bhamplateletgrp and @ICVS_UoB published in @BloodJournal yesterday. We show that PF4 itself activates platelets via the TPO receptor c-MPL.
Super pleased to see that NICE has approved Ruxolitinib for PV in England !! @MPNVoice FDG published today.
Let’s get on and test this drug in the front line as the Mithridate study being run jointly between 🇫🇷 and 🇬🇧 with @jjkiladjian
@BookshopOTGreen Ah so sorry to hear this, my boys and I loved having the bookshop nearby. Good luck with the next chapter, and hope that it continues to bring happiness to the local area!
@MorphologyAmigo Have never come across this scenario! Broadly speaking allergies need close scrutiny-thorough history, speak to pharmacy and immunology. ATRA is so crucial though that I’d be likely to press on with it (maybe the dexamethasone cover for differentiation syndrome will ameliorate!)