Haldar Lab @ Penn

The Haldar Lab at the University of Pennsylvania studies mononuclear phagocytes in the tumor microenvironment.

[Haldar Lab @ Penn @haldar_lab]

RALDH1-inh presents a potential strategy for #HCC #immunotherapy. We demonstrate that RALDH1-KO tumors have hindered growth and enhanced infiltration of activated T cells. We also see that RALDH1-KO mice develop normally and do not show toxicity.

[Haldar Lab @ Penn @haldar_lab]

Exciting news! We have demonstrated the efficacy of RALDH1-selective inhibitors in restraining tumor growth in models of #HCC. See our paper in @AACR's #CancerImmunologyResearch.
https://t.co/a5zYBVTjyp

[Haldar Lab @ Penn @haldar_lab]

RALDH1-inh treatment reduces tumor burden in mouse models of #HCC. The suppression of tumor-derived RA and its effect on the #TME drives this phenotype, as proliferation and viability in vitro are unaffected. Depletion of macrophages renders tumors insensitive to RALDH1-inh.

[Haldar Lab @ Penn @haldar_lab]

@CAMBUpenn Follow up: congratulations, Dr. Lobel! We wish Graham all the best as he returns to medical school, and we’re already missing him around BRB!

[Haldar Lab @ Penn @haldar_lab]

@CAMBUpenn Follow up: congratulations, Dr. Lobel! We wish Graham all the best as he returns to medical school, and we’re already missing him around BRB!

[CAMB Graduate Group @CAMBUpenn]

Graham Lobel from the Haldar/Simon labs defends tomorrow!

[Haldar Lab @ Penn @haldar_lab]

Very proud of our SUIP student Lorraine for her work this summer! Lorraine worked with Shoush investigating dendritic cell migration from the tumor microenvironment. We wish you the best and hope you keep in touch, Lorraine!

[Haldar Lab @ Penn @haldar_lab]

Haldar labites celebrating the 4th!!! 🎇