Rapid diagnostic tests combined with individualised decision-making improve the selection of antibiotic therapy. Rapid de-escalation to narrow-spectrum monotherapy and shortening of the duration of therapy should be the rule. #IDXposts
1/2 🦠 It's World Antimicrobial Resistance Awareness Week 2024! 🌍
Join us in spreading the word about the importance of using antibiotics wisely.
At Lancashire Teaching Hospitals we are proud to hear voices of the future remind us why this is important in the video below.
@ABsteward Similarly making decisions about oral step down based on numbers and ignoring clear clinical evidence of response. It all comes down to common sense sometimes!
#idboardreview Few household members & veterinary staff got exposed to a pregnant stray dog who later aborted puppies IFA +brucella canis & pcr+vaginal secretions. 2 ppl had direct contact w/dog's placenta without PPE. What abx prophylaxis? #idxposts#idmeded#meded
I guess it's time for my daily rant. Im old enough to remember when this first negative day of culture nonsense started.
Back in the bad old days of the cretaceous era, when I was an ID fellow and rode the brontosaurus to work...
"There isn’t an ID doc in this country who hasn’t been at the bedside of a patient who’s desperately ill & for whom we did not have an antibiotic.” @IDSAInfo President Dr. Cynthia Sears. #IDquotes#IDTwitter
Retweet if you ever had a patient with no #antibiotic to treat.
@drtimothyli@BradSpellberg@DrToddLee@IdVilchez@wwrighID I guess it’s always the eternal question is this colonization or infection? If needs targeting then would agree Ceftazidime single agent. If f no clinical response maybe consideration of adding in nebulised antibiotics - Amikacin is an option, can’t see colomycin/colistin tested
@antonio_bu12125@BradSpellberg@ABsteward There could be a number of factors at play, such as source for instance. By all means in the end It all comes down to careful monitoring of clinical response coupled with antimicrobial susceptibility testing / identifying mechanisms of resistance to tailor the treatment regimen.
Valproate serum concentration 🔽 when co-administered with a carbapenem
Clinical Sequelae?
🆕️🔥Retrospective Analysis @OFIDJournal
In those prescribed valproate for its antiepileptic properties seizures occurred after carbapenem Rx in 46.3% of encounters https://t.co/gz4OZCxkGm
@MicroLukas Answer is C I think, Cefpodoxime resistant ESBL/AmpC also confirmed by ceftazidime / cefotaxime resistance. Yet does not explain the errapenem resistance and therefore porin loss would be the likely possibility here.