ASHansen Lab

We seek to understand the molecular mechanisms that regulate genome organization and gene expression in time and space.
Based in @MITdeptofBE

[Anders Sejr Hansen @Anders_S_Hansen]

Come on join us! We are searching for the next technical associate to join our lab ~Summer 2026.

This could be a great position for someone who is graduating this spring and is looking for 2 more years of research experience before starting their PhD:
https://t.co/6IiVUnrLO8

[ASHansen Lab @hansen_lab]

Welcome to lab, Xu, Steven, Mira, and Carolina!

[ASHansen Lab @hansen_lab]

We had a wonderful time celebrating together at our lab’s holiday party, enjoying good company, good food, and a very fun lab trivia. Grateful for a great year and an even better team!

[ASHansen Lab @hansen_lab]

Welcome Sushanta Mahanta to the lab!

[MIT Dept of BE @MITdeptofBE]

The @Anders_S_Hansen Lab find tiny loops in the genomes of dividing cells. Enabled by a new high-resolution mapping technique, the findings overturn a long-held belief that the genome loses its 3D structure when cells divide. @NatureSMB https://t.co/t5Zc0nCvgx

[ASHansen Lab @hansen_lab]

New 2025 lab photo

[Anders Sejr Hansen @Anders_S_Hansen]

Jamie Drayton and I were fortunate to contribute RCMC to this beautiful paper from Eder, Moene...van Steensel that systematically maps the relationship between enhancer location and gene expression (and nice to see RCMC predict expression in Fig 2H-I): https://t.co/FwU5MaRLwW

[Anders Sejr Hansen @Anders_S_Hansen]

Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin.

STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
https://t.co/DDjriqPFKE

[MIT Dept of BE @MITdeptofBE]

Who's up at BATS?
@VarshiniRam23 (@hansen_lab @Anders_S_Hansen): “3D Genomic Mapping Across Human Erythropoiesis” https://t.co/UUBCQauu8x

[Anders Sejr Hansen @Anders_S_Hansen]

Congratulations to Dr. Viraat Goel and Dr. Domenic Narducci, both new PhDs in Biological Engineering from the lab!

[Anders Sejr Hansen @Anders_S_Hansen]

(1/13) Thread on @mazzocca_matteo @DomenicNarducci @SGrosseHolz @_jessematthias new preprint

Q: how does chromatin move?

Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide some answers
https://t.co/5BgjT7ujcO

[Anders Sejr Hansen @Anders_S_Hansen]

(1/n) New preprint from @claricehongky Fan Fang @VarshiniRam23 in collab w Jie Liu

Q: How do we get ultra-high-res 3D genome maps?

A: New deep learning model, Cleopatra.

Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps
https://t.co/Wf7tppUk2p

[Anders Sejr Hansen @Anders_S_Hansen]

Check out Masahiro Nagano's preview https://t.co/I37WuLUtKK of a very cool paper from Tjalsma...Wouter de Laat: https://t.co/YG81dyMP6f

[Anders Sejr Hansen @Anders_S_Hansen]

Mostly on BlåSky but excited to share James Jusuf's preprint:

By integrating Micro-C with SuperRes Live-Imaging we perform absolute quantification of looping (e.g. this loop is present 3%).

We quantify mESC 36k loops: <loops> are generally rare (2.3%).
https://t.co/XmpmWHV66O

[Anders Sejr Hansen @Anders_S_Hansen]

Our preprint by @DomenicNarducci and the companion preprint by @deWitLab are now out in @MolecularCell

ZNF143 is not a general looping factor and was identified as such due to a non-specific antibody. Instead it is TF with the longest residence time measured (to our knowledge)

[Anders Sejr Hansen @Anders_S_Hansen]

Very grateful to @NIH_CommonFund for funding our Transformative Research Award #NIHHighRisk

[ASHansen Lab @hansen_lab]

Congrats to @ViraatGoel James Jusuf et al. on new preprint in collab with @Irate_Physicist @blobelgroup @leonidmirny discovering transient microcompartments that connect enhancers and promoters in mitotic chromosomes: https://t.co/9JucE3wH3K

[Anders Sejr Hansen @Anders_S_Hansen]

(1/n) From @ViraatGoel @Irate_Physicist et al. collab w @blobelgroup @leonidmirny https://t.co/CdI7n2P31a

RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry

Sims reveal chromosome compaction as key regulator

[ASHansen Lab @hansen_lab]

Come and see James' BATS talk today

[MIT Dept of BE @MITdeptofBE]

First BATS of the academic year 2024/25 🥳!
James Jusuf (@hansen_lab): “Genome-Wide Absolute Quantification of Chromatin Looping”
https://t.co/cl8idnM5ja

[Anders Sejr Hansen @Anders_S_Hansen]

Congrats to @GavinSchlissel @Pulin_Li with single-molecule imaging contribution from @DomenicNarducci @hansen_lab

Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: https://t.co/Byzkemhgvv

[Anders Sejr Hansen @Anders_S_Hansen]

Congrats to @ngaboreden @blobelgroup with RCMC contribution from @ViraatGoel @hansen_lab .

Having recently worked on what we thought was a looping factor (ZNF143 https://t.co/ltSEKYv3TG ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 https://t.co/YR5gYcxNjS