Our paper showing the mechanism of cytokine storm during SARS-CoV-2 infection is now online in eLife. We demonstrate that spike protein, upon sensing by TLR2, induces inflammatory cytokines in macrophages, monocytes and epithelial cells.
https://t.co/9ShbK9SD4W
A study from the @hasanzaki02 lab via @eLife, provides critical insight into a molecular mechanism that may contribute to cytokine storm during SARS-CoV-2 infection and suggests potential drug targets. https://t.co/tWR4WwYqh0
Findings help to explain gastrointestinal comorbidities seen in neurodevelopmental disorders such as ASD Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells https://t.co/MuG9Ea6Z3x
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has awarded Dr. Hasan Zaki, a RO1 grant to study the Inflammasome in the Regulation of Intestinal Glucose Homeostasis, Microbiota and Inflammation. Congratulations! @hasanzaki02
https://t.co/otKER3uIIF
Revolutionary work by UTSW Pathology faculty Dr. Yang-Xin Fu and Dr. Hasan Zaki was recently published in Science Immunology: "The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation" @UTSWScience
https://t.co/4tilMEkuNp
Our study exploring a mechanism of how SARS-CoV-2 triggers inflammatory response.
SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway https://t.co/TJQrR0pkTe
Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice https://t.co/NVmqJffudp
We are very excited to see our work published in Science Translational Medicine. I thank to all my lab members and co-authors for their great effort and support.