Top Tweets for #4FPCC
5a) The primary adverse effect #AE that #andexanet_alfa & #4FPCC share after treatment is:
a. allergic reactions
b. development of anti-drug antibodies
c. thrombotic complications
d. local reactions at infusion site
15b) On the other🖐️, treatment w/#anticoag #reversal or hemostatic tx (e.g. #4FPCC) should be done judiciously for the right patient at the right time. For example, #andexanet_alfa acts quickly such that pts protected from underlying clot risk by #DOAC are suddenly unprotected.
Published today! Our experience as a Pharmacist driven anticoagulation reversal program https://t.co/8ECxytatAC @PharmDTomps @RuchiJ_PharmD #4FPCC #Andexxa #anticoagulationreversal #TwitteRx #EMRx
New retrospective study of andexa vs 4PCC for Xa reversal among VA pts showing a large decrease in in-hosp mortality with andexa (10.6% vs 25.3%). However, some large differences in baseline characteristics btwn groups notably the apixaban/LMWH numbers
https://t.co/4LenLoTTjk
#4FPCC No Help in #TraumaPatients at Risk of Massive #Transfusion
— Randomized trial shows no significant reduction in 24-hour blood product consumption vs placebo
Pierre Bouzat, MD, et al. Hôpital Albert Michallon
https://t.co/LeLKWHDAif
@medpagetoday
Happy Pharmacy Friday!
Here are some information about KCentra.
📖 Check out our recent pearl Fixed-Dose 4-Factor Prothrombin Complex Concentrate for Emergent Vitamin K Antagonist Reversal in our website.
#kcentra #4fpcc #warfarin #pharmacypearls #empharmacy #pharmacist
Happy Pharmacy Friday!
OUR NEW PEARL IS OUT NOW.
📖 Visit our website to learn and download resources about Fixed-Dose 4-Factor Prothrombin Complex Concentrate for Emergent Vitamin K Antagonist Reversal.
#kcentra #4fpcc #warfarin #pharmacypearls #empharmacy #medicine #pharmacist
We will have a new pearl this week!
📖 Stay tuned on our website to learn and download resources about Fixed-Dose 4-Factor Prothrombin Complex Concentrate for Emergent Vitamin K Antagonist Reversal.
#kcentra #4fpcc #warfarin #pharmacypearls #empharmacy #medicine #pharmacist
Con 24 horas de retraso, lo prometido es deuda 🙂🤓
Aquí va INFO sobre el uso del 4F-PCC 🩸 (complejo protrombínico) en el Manejo del Sangrado en Pacientes en Tratamiento con Anticoagulantes Orales
Abro hilo! 🧵
😱 A case series reported thromboembolic events after treatment with 4F-PCC and andexanet alfa
⚠️ Thrombotic rate was 40%! #4FPCC #andexanetalfa #anticoagulationreversal
❌ Limited evidence and safety concerns with administration of both agents!
https://t.co/l6AUkufD1s
Congratulations @stacypasciolla!! Your hard work, determination, and countless hours of V=(a*b*c)/2 have finally paid off!!! 🧠🩸
2021 is being good to us 🎉🎉
#warfarin #apixaban #rivaroxaban #4fpcc #intracranialhemorrhage #pharmicu #icuwomen
https://t.co/lT7onK1xyC
@ASHP_EMPharm A8. Not necessarily other than using the reduced #4FPCC ~500 unit dose. However, I usually try to utilize #FFP for refractory bleeding after an appropriate reversal dose #ASHPEMchat
@ASHP_EMPharm A5. Fixed-dose #4FPCC >>>>
VKA ICH: ~1500 units
VKA non-ICH: ~1000 units
DOAC (ICH and non-ICH… and pretty much any other indication): ~2000 units
Repeat/supplemental dose: ~500 units
#ASHPEMchat
@ASHP_EMPharm A2. We primarily use central pharmacy to compound our reversal agents. For #4FPCC, we have a rapid triage and compounding process to expedite treatment for the acute conditions that typically coincide with a need for anticoag reversal #ACreversal #ASHPEMchat
🆕 in print!
#4fPCC 🆚 #rFVIIa for mngmnt of 🩸 w/ #cardiacsurgery
▫️1000U 4fPCC (15u/kg) & 2mg rFVIIa (20mcg/kg) comparable at hemostasis in our cohort
▫️#thromboembolic events 13🆚26% @ 30d
@ColombianpharmD @ArnoukSerena @MarshK_PharmD @JPCritCarePharm
https://t.co/2zHm33lHoN
#Review Prothrombin Complex Concentrate for Warfarin Reversal in Patients with Continuous-Flow Left Ventricular Assist Devices: A Narrative Review
https://t.co/KY4YfFn5lq
@Prof_J_NYC @nyphospital @BrighamWomens @harvardmed
#LVAD #AnticoagulationReversal #4FPCC
We evaluated high dose #4FPCC (#Kcentra) for reversal of #warfarin #ICH to limit hematoma expansion 💉
High dose (median 2000 units) 4FPCC lowered INR more effectively, but did not demonstrate improved neurologic outcomes🤯
@ColombianpharmD @VeePharmD
Check out our results ⤵️
New publication with @TaniaAhuja @VeePharmD 4FPCC reversal in warfarin induced ICH. Dosing scheme displayed below with summary #PCC #Foamcc #reversal https://t.co/FXVKcrlDhP
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