Top Tweets for #4KScore
š©ŗDr. Roach: PSA tests in men over 75 can place them on a harmful path. "We are much better at identifying men whose risks are so low that they can be watched by a combination of the biopsy results, the #PSA level, perhaps a genetic test like the #4Kscore, and the size of the tumor (by a CT or MRI scan)". https://t.co/VwUfMl7xs3 via @detroitnews / ā¹ļø @4Kscore
In response to @Brabbott42 Prostate-Cancer Diagnoses Spur Rethinking of Screening Guidelines -- @WSJ.
One such test that fills the gap between PSA and Biopsy is the #4Kscore. This @US_FDA approved test can distinguish men with a low risk of having aggressive prostate cancer on #biopsy from those with a high risk, helping to avoid unnecessary biopsies and overtreatment of indolent disease.
The 4KscoreĀ® test is included in prostate cancer early detection guidelines as a follow-up test to help improve the specificity of #PSA screening, and should be used in an overall evaluation for a manās prostate cancer risk.
A Multi-Institutional Prospective Trial assessed the 4Kscore's performance in a cohort of men with a large African American representation. The test accurately predicted aggressive #prostatecancer for biopsy decision making in African American and non-African American men.
https://t.co/W2o37VLhG4
REFERENCE
At the #AUA2023 @AmerUrological Annual Meeting, OPKO Health's $OPK FDA approved #4Kscore test was highlighted in a Moderated Poster Session by Jessica Delgado, MD,BS,MS -University of Miami/ Jackson Health System.
Session: MP55: Prostate Cancer: Detection & Screening III
MP55-05: "Baseline 4K Score Predicts Progression on Active Surveillance in Prostate Cancer Independently of Clinical Information and PIRADS Score" concluded that Patients with a 4Kscore above 20% have a higher likelihood of progression despite their NCCN risk and MRI findings.
https://t.co/LPC2DKaZsJ / https://t.co/jPBpJQxnwa
It is also important to note that the #AUA2023 take home messages on Health Care Disparities noted that: The AUA and National Comprehensive Cancer Network guidelines recommend PSA screenings at an increased rate at earlier ages in Black men. The low specificity of PSA requires the use of secondary tools such as multiparametric MRI of the prostate, 4Kscore, Prostate Health Index, or ExoDx. These are not calibrated in minority populations. Moreover, there are disparities in the utilization of these risk prediction tools in biopsy-naĆÆve Black men.
https://t.co/93uVnXtIhU
Finally, I would like to point out in 2017 that a Multi-Institutional Prospective Trial confirmed that the 4KscoreĀ® test accurately predicts aggressive prostate cancer for biopsy decision making in African American and nonAfrican American men.
A Multi-Institutional Prospective Trial Confirms Noninvasive Blood Test Maintains Predictive Value in African American Men
Punnen S, Freedland SJ, Polascik TJ, Loeb S, Risk MC, Savage S, Mathur SC, Uchio E, Dong Y, Silberstein JL. A Multi-Institutional Prospective Trial Confirms Noninvasive Blood Test Maintains Predictive Value in African American Men. J Urol. 2018 Jun;199(6):1459-1463. doi: 10.1016/j.juro.2017.11.113. Epub 2017 Dec 6. PMID: 29223389.
https://t.co/QZvUfijrKI
The #4Kscore also has a @CMSGov Local Coverage Determination (LCD) for for Medicare payments. @4Kscore
https://t.co/Ye2QrGAhX0
The #FDA approved OPKO Health $OPK #4KscoreĀ® Test that Helps Clarify the Biopsy Decision-Making Process by Determining a Patient-Specific Probability for Finding Aggressive #Prostate Cancer on Biopsy. https://t.co/8RW70lK7co
4Kscore Test ā P190022
https://t.co/wI3ysplI7T
A recent multi-institutional study has found that using both an MRI and 4Kscore together was superior to using either test alone but found no appreciable difference between starting with an MRI vs. starting with a 4Kscore. https://t.co/7sIzjrhY71
The Eur Urol Open Sci. 2023 Jun; 52: 1ā3. study Published online 2023 Apr 29. doi:Ā 10.1016/j.euros.2023.03.011 titled: āImplementation of 4Kscore as a Secondary Test Before Prostate Biopsy: Impact on US Population Trends for Prostate Cancerā estimated that each year, the 4Kscore leads to 45 200 fewer biopsies and 9400 fewer overdiagnoses of low-grade cancer, at the cost of delayed diagnosis of high-grade prostate cancer for 3450 patients, of whom two-thirds have International Society of Urological Pathology grade group 2 disease. https://t.co/7NTVVBoGDW
It was also reported on Thursday, June 15, 2023 by Discoveries in Health Policy that at the June 22, 2023, #CMS meeting, #IsoPSA requested crosswalk to the 81549 4KScore price, $760. https://t.co/bMI2c6hZp0
The 4KscoreĀ® Test is a follow-up blood test after an abnormal PSA (Prostate Specific Antigen) or digital rectal exam (DRE) to provide the probability of finding aggressive prostate cancer if a biopsy were to be performed. The 4KscoreĀ® Test combines measurements of four prostate-specific biomarkers along with patient clinical information in an algorithm to accurately predict a manās pobability for aggressive prostate cancer. Understanding the probability of finding aggressive prostate cancer gives a patient and a physician more information to decide if a prostate biopsy is warranted.
The 4KscoreĀ® Test measures four prostate-specific kallikreins: Total PSA, Free PSA, Intact PSA, and human kallikrein 2 (hk2) in addition to incorporating clinical results. Total PSA and Free PSA are important markers for prostate cancer but have low specificity for risk of aggressive prostate cancer. Intact PSA and human kallikrein 2 (hk2) are present in much lower concentrations than total PSA and Free PSA, and changes in these biomarkers are associated with aggressive types of prostate cancer.
A prospective U.S.ābased validation study of The 4KscoreĀ® Test in 1012 men examined the accuracy of the test to predict the probability of high-grade cancer on biopsy and the contributions of the different test components. The Area Under the Curve (AUC) for The 4KscoreĀ® Test was 0.82 compared to 0.74 for a PSAābased probablity calculator. Intact PSA and human kallikrein 2 (hk2) contributed 0.07 to the AUC of The 4Kscore Test, which was a significant contribution. The 4KscoreĀ® Test predicted probability of high-grade cancer with high calibration to the true probability observed in the study.
@AlexHermen @RomanCarvajal @EdgarLindenMD @MarcelaPelayo @ferchein @UroMedrano Claro, cada caso es diferente y las guĆas no son receta de cocina, sin embargo el $$ de la #mpMR ha disminuido en los Ćŗltimos aƱos, no olvidar la utilidad del #PSAd y #ERSPC y #4KScore para mejorar el diagnĆ³stico de #csPCa
Weāre pleased to share that the @4Kscore test has been approved by the U.S. Food and Drug Administration (FDA) for use in men age 45 and older who qualify. The 4Kscore is available at BioReference and @GenPath. Read more: https://t.co/l9ZgJJd8K3 #4kscore #ProstateCancer #FDA
Increasing public awareness about the importance of prostate health and prostate cancer is a critical step in detection and diagnosis of the disease. More: https://t.co/MYSCSswGFr #ProstateCancer #PCAwareness #4Kscore
What side of the line do you want your patients on? Share the importance of prevention and early detection and, if theyāre age 45 or older, talk to them about scheduling a PSA or DRE. #prostatecancer #prostatehealth #prostatecancerawareness #4Kscore #4Kscoretest #menshealth
@DrRastinehad @daviesbj @LoebStacy See this old tweet. Kallikreins only add 0.1 to the AUC, which is primarily driven by the clinical nomogram. #4kscore ridiculous
@wandering_gu @daviesbj @UROncDoc Went through it. Eye opening.
Base model of clinical factors (Age, PSA, DRE) AUC 0.635
Kallikrein's generally add 0.1 to the AUC
Which begs the question I've been asking all along.
Is it worth it to pay the expense for this test, which adds 0.1 to the AUC?
OUTSIDE REFERRAL->PATIENT ANXIETY, 74% #4kscore, I filled out questionnaire completely and repeated it. Look at the impact on the #4kscore.. this means their test is really useless and they use a #RISKCALCULATOR instead of the PSA isomers to determine risk @daviesbj @LoebStacy
A #4Kscore test could help some men avoid a prostate biopsy. Learn how this test works to diagnose prostate cancer, and how it compares to traditional screening methods. https://t.co/S9g1LE6jcn #prostatecancerawareness #cancerprevention
TĆ¼rk #Ćroloji Akademisi Multidisipliner #Ćroonkoloji GĆ¼ncelleme Toplantısında "#ProstatKanseri Tanısında #PSA ve MolekĆ¼ler BelirteƧler" konusundaki yenilikleri gƶzden geƧirdik. #phi #SelectMDx #ConfirmMDx #progensa #PCA3 #4KScore #MiPS #ExoDx #prostatecancer @uroturk
If you & your doctor determine that the 4Kscore Test is right for you, getting your #4Kscore Test is simple. Follow these 3 steps then head to https://t.co/yjlcpDhDpt for more information regarding the diagnostic blood test that assesses your risk for aggressive prostate cancer.
Weāre heading west! #4Kscore will be exhibiting at the @TxUrologicalSoc Annual Meeting in #SanFrancisco! If youāre attending the event stop by the OPKO Health booth to learn more about 4Kscore!
Today kicks off the start of National #MensHealthWeek! Follow along with us this week as we share tips, videos and statistics about prostate health for men of ALL ages! #menshealth #prostatehealth #4Kscore #realmengetchecked #whatsyourscore
#4Kscore is exhibiting at the #AUA2019 Conference today! If youāre an #HCP and in the #Chicago area stop by booth 2608 to learn more about the diagnostic blood test used after an abnormal PSA or DRE to identify the risk for aggressive #prostatecancer. We hope to see you there!
As the saying goes, #knowledgeispower. Once you and your urologist have decided that the #4Kscore diagnostic test is the right choice for you, knowing what to expect and understanding your results can help ease your mind during the process. Learn moreā”ļø https://t.co/JfPCIN8Onw
With all the new discoveries about #prostatecancer it can be hard to keep up with the many different elements that are involved. Here is some basic yet vital information to consider when thinking about your #prostatehealth: https://t.co/jLbYpgXsrJ #4Kscore #cancerawareness
Have men in your family been diagnosed with #prostatecancer? 5-10% of prostate cancers diagnosed are hereditary. Your family history can open the conversation about #prostatehealth with the men in your life.
Find out if youāre a candidate for #4Kscore: https://t.co/qNKx2bMkmn
Itās #WorldHealthDay and weāre putting the focus on #prostatehealth. Talk to your urologist about your prostate health and celebrate this day by making YOUR health your WORLD! #prostatecancer #urologist #4Kscore
Check out some FAQās for your doctor: https://t.co/oRNXaQHIjA
Men concerned about their risk for aggressive #prostatecancer often hear terms like #PSA, #4Kscore, & #biopsy being used simultaneously. Whatās the difference? How do you know which is right for you? We answered all your #PSA questions here: https://t.co/GLFsZ2iBd6
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