Top Tweets for #ACSVL1

about 1 year ago

#Bempedoic acid is good alternative in patients with a history of #statin-related #myotoxicity. This drug is not associated with myopathy, #myositis, and myonecrosis unlike statins, as the #ACSVL1 enzyme, which is responsible for converting bempedoic acid to its active form, bempedoyl-CoA, is not expressed in skeletal #muscles, leading to fewer musculoskeletal side effects. Data from randomized controlled trials support to the safety and efficacy of bempedoic acid in lowering LDL-C in statin-intolerant patients. In the CLEAR Serenity trial, 93% of patients reported a history of statin-associated #muscle symptoms at baseline. #Myalgias and new-onset or worsening diabetes was seen less frequently in the bempedoic acid than the placebo group. More patients in the placebo group discontinued the drug due to muscle-related symptoms. However, an important parameter to monitor in patients treated with bempedoic acid are serum #uric acid levels. Elevations in uric acid were more commonly in the group that received bempedoic acid in clinical, though mean uric acid elevations remained stable after four weeks of treatment and were not accompanied by new or worsening #gout. *Buda KG, Dopal DJ. Guest Editorial: Bempedoic Acid Therapy for Patients with Statin Intolerance. National Lipid Association. 🔗https://t.co/ttW6TPnBP2

alb_giraldo's tweet photo. #Bempedoic acid is good alternative in patients with a history of #statin-related #myotoxicity. This drug is not associated with myopathy, #myositis, and myonecrosis unlike statins, as the #ACSVL1 enzyme, which is responsible for converting bempedoic acid to its active form, bempedoyl-CoA, is not expressed in skeletal #muscles, leading to fewer musculoskeletal side effects.

Data from randomized controlled trials support to the safety and efficacy of bempedoic acid in lowering LDL-C in statin-intolerant patients. In the CLEAR Serenity trial, 93% of patients reported a history of statin-associated #muscle symptoms at baseline. #Myalgias and new-onset or worsening diabetes was seen less frequently in the bempedoic acid than the placebo group. More patients in the placebo group discontinued the drug due to muscle-related symptoms.

However, an important parameter to monitor in patients treated with bempedoic acid are serum #uric acid levels. Elevations in uric acid were more commonly in the group that received bempedoic acid in clinical, though mean uric acid elevations remained stable after four weeks of treatment and were not accompanied by new or worsening #gout.

*Buda KG, Dopal DJ. Guest Editorial: Bempedoic Acid Therapy for Patients with Statin Intolerance. National Lipid Association.
🔗https://t.co/ttW6TPnBP2

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Esperion Inc.

@EsperionInc

almost 10 years ago

The #ACSVL1 enzyme is found in the liver, but not in skeletal muscle. #BempedoicAacid has minimal risk for the muscle-related side effects.

Esperion Inc.

@EsperionInc

almost 10 years ago

The publication notes #BempedoicAcid is a prodrug requiring #ACSVL1 activation & that inhibition of #ACL leads to #LDL receptor upregulation

Asclepia Capital @asclepiacap

almost 11 years ago

$ESPR #ACSVL1 expression is restricted to liver and kidney. No expression in skeletal muscle. #AHA2015 #ETC1002 #ACL

Esperion Inc.

@EsperionInc

almost 11 years ago

#ACSVL1 is the specific acetyl CoA synthetase that was identified. #AHA2015 #ETC1002

Esperion Inc.

@EsperionInc

almost 11 years ago

#ACSVL1 expression is restricted to liver and kidney. No expression in skeletal muscle. #AHA2015 #ETC1002 #ACL

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