Top Tweets for #ANK3
🇨🇳 #Denovo Biopharma announced that results from its pivotal ENLIGHTEN trial have been published in JAMA Psychiatry. The study demonstrated robust efficacy of DB104 (#liafensine) in treatment-resistant depression (TRD) patients carrying a novel pharmacogenomic biomarker, #ANK3. https://t.co/msCZZSYUj8
The biomarker‑guided, randomized, double-blind, placebo-controlled Phase 2b trial was conducted at 58 sites across the US, Canada, and China.
The success of this pivotal study led to Fast Track Designation by the FDA, and Denovo needs just one more positive pivotal study before filing an NDA for liafensine in treating ANK3 positive TRD patients.
The primary endpoint was the Montgomery-Åsberg Depression Rating Scale (MADRS) total score change from baseline (CFB) at week 6 in ANK3-positive TRD patients. Liafensine showed a 4.4-point improvement over placebo (P=0.006), a clinically meaningful and statistically significant improvement. This result replicated the 4.7-point MADRS improvement observed from biomarker-based retrospective analyses of prior studies.
We need a low dose lithium er and lamotrigine xr ODT / oral combo for #epilepsy #bipolar #borderline #trd @US_FDA @NIMHgov @CDCgov @GileadSciences #cacna1c #ank3 #Grik1 #bdnf @chrisaikenmd https://t.co/OAglJkJNGO
The phenotypic and genotypic spectrum of individuals with mono- or biallelic #ANK3 variants. Our work is now online showing the main clinical features of ANK3: intellectual disability, developmental delay, behavioral issues, hypotonia, sleep disturbances, and epilepsy.
Publication alert 📢 The phenotypic and genotypic spectrum of individuals with mono- or biallelic #ANK3 variants ‼️
Excellent work by our phd-students @FrancescaFuria_ & Amanda Levy 👏👏
#Epilepsy 🧠 #Genetics 🧬 #SCN8A
@ZeynepTumer_DK @Elegardella https://t.co/R3w9C7lAay
Or meet our team at the poster sessions where we will present our work on #GABRB2, #ANK3, #MBOAT, #SCN1A/#SCN2A/#SCN8A, #TRIO 🧠🧬
#Epilepsy #IEC2023
@Sebasortizdelar @TrinebjR @sopio_gverd @NazaninAzarine1 @Katrine92658231 @FrancescaFuria_ @Philip_K_Ahring @caterina_ancora
Metal Emekçisinin Umudu En Büyük dayanağı gücüne güç katarak her gün dahada büyüyerek kök salan Teşkilatımızın,
Bilge Liderimiz sn Pevrul Kavlak’ın her daim Yanında Emrinde bir adım gerisinde izindeyiz
#KocaÇınar60Yaşında
#TürkMetalSenkası
#PevrulKAVLAK
#TürkMetalSendikası
#ank3
.@FrancescaFuria_ developed a severity score for the #ANK3 cohort, e.g. a more severe phenotype is seen in the truncating and esp. biallelic cases. #LEGOLAS
She is also looking for #SCN8A patients for another project of hers.
Next talk by @FrancescaFuria_ at #LEGOLAS about #ANK3-related disorders. Cohort comprises 40 ind. of up to 45 years of age. There are AD + AR cases. Spectrum is ID, autism, epilepsy (40%) + sleep disorders. She wants to build on previous publications.
https://t.co/MsG9gHDkAG
#ANK3 #ADHD #anger #BipolarDisorder #migraine #seizures #autism #hallucinations https://t.co/W8diCMH0ua
Phew 😅 - then we still have time to finalize our abstracts on #GABRG2, #GABRB2, #GABRB3, #GABRA3, #ANK3, #DLG4, #TRIO, #GRIA3, #MBOAT7 and #SCN8A related epilepsies 😆😆
@AllanBayat @Sebasortizdelar @BeneKassabian @caterina_ancora @AleRossiNeuro @Katrine92658231 @Philip_K_Ahring
Deadline Extended! Due to demand the deadline to submit an abstract for #IEC2023 has been extended by one week - https://t.co/R4LDbJ1uvV! Extended deadline: 27 January 2023
@IBESocialMedia @yesILAE #epilepsy #epilepsyeducation #epilepsyresearch
Take home message #2: Pk is probably the earliest binding partner of the product of #ANK3, a critical gene in bipolar disorder (BD), schizophrenia (SZ), and autism spectrum disorder (ASD). Pk may modulate AnkG in more than one compartment of the neuron
Welcome to #Neurotwitter @ZeynepTumer_DK 😃
Zeynep is a prof. in neurogenetics at @DRigshospitalet
Her research group studies the underlying genetic 🧬and epigenetic mechanisms in rare NDDs🧠 (incl. #CACNA1A, #ANK3, #DLG4 👇)
Give her a follow ‼️
https://t.co/kGI48EfqLM
Cantik x mummy?
#Ank3
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