Top Tweets for #Arcalyst
If $CRDL can replicate today's data in the coming Ph-3 trail, it will become first choice of any #Pericarditis patient & take a large market-shart from Kiniksa's rilonacept (#Arcalyst)
Just think about the data compared to rilonacept, an FDA-approved but immunosuppressive drug!
If I'm a 25 or 35-year-old with recurrent #pericarditis that limits my life & causes unbearable pain, and my physician gives me the choice between CardiolRx, an oral cannabidiol drug with very low adverse events and rilonacept, the choice is clear.
CardiolRx showed that 71% of patients remained recurrence-free during the 18-week extension period. In comparison, in the RHAPSODY trial of rilonacept for recurrent pericarditis, 81% of patients remained recurrence-free during the treatment period.
However, rilonacept comes with the burden of being a harsh immunosuppressive drug, increasing the risk of infections as it lowers my immune system. This risk is significant if I want to maintain a normal life, such as working or attending social events with many people around. I would choose CardiolRx without a second thought!
The market's reaction to $CRDL's data releases today can be confusing, especially when positive data doesn't lead to an immediate price increase!
Looks the same as post the 8Wks data release, a drop & bounce back after understanding how meaningful the data is vs the #Immunosupressive drug approved by FDA!!!
๐ขMarked, rapid, and durable reductions in both pericarditis pain & inflammation were observed in the study, and importantly, these reductions were maintained throughout the 6-month study in a recurrent #pericarditis population with a significant disease burden.
๐ขAt week 8, 93% (25/27) of patients reported a pain score reduction.
๐ข3.7 NRS score reduction at week 8 from 5.8 Base-Line to 2.1
4.3 NRS score reduction at week 26 from 5.8 to 1.5
๐ขThe median time to resolution or near-resolution of pain (i.e., NRS โค 2) was rapid, observed in just 5 days following initiation of CardiolRx treatment
๐ขCRP levels for the entire group of patients were reduced from 2.0 mg/dL at baseline to 0.74 and 0.55 at weeks 8 and 26 respectively, with a median time to CRP normalization of 21 days.
๐ข Freedom from recurrence was maintained in 71% (17/24) of patients during the EP when CardiolRxโข was continued and patients were weaned off baseline medications.
For those patients experiencing a recurrence the median time to an episode was 7.7 weeks during the EP!
๐ข Number of pericarditis episodes per year was markedly reduced from 5.8 prior to study to 0.9 during the study.
The chances of $CRDL taking over large part of $KNSA market share are high, where the drug price will be much lower & the safety will have a crucial advantage in young adults that prefer to stay away from an "Immunosuppressive drug" like #Rilonacept or #Arcalyst
Also with $KNSA faces challenges in penetrating the market for 1st recurrence patients, with only 15% of these patients, while $CRDL can be 1st in line for 1st recurrence!
Looks like $KNSA should be worried & starts thinking to buy-out $CRDL before they take their rilonacept potential
$CRDL's CEO said, expanding the market opportunity with MAVERIC-2 into new patients population & provides a path for an accelerated regulatory approval timeline.
@AHAScience Twitter Gustavo ๐ซ๐ซถ๐๐ปโโ๏ธ ๐จ: 13,403 points at 2:52 PM #AHA22 #kiniksa #pericarditisrx #arcalyst

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