Top Tweets for #BioProcessing
How much does your pH probe drift per autoclave cycle? Standard glass: up to 0.25 pH. High-temp glass: <0.05 for 50 cycles. Recalibration workflow + replacement criteria:
https://t.co/mDPk9hld76
#Bioprocessing #PAT
What does it take to make a bioprocess reproducible from one run to the next?
Discover Multifors 3 and what it means for reproducible process development: https://t.co/XjsQmIoQ8k
#Bioprocessing #ProcessDevelopment #Bioreactor #CellCulture #TechnologyTransfer
Lysis 92%. Washing 87%. Solubilization 92%. Overall inclusion body recovery: 28%.
Step yields multiply, so refolding at 38% sets the ceiling. +10 pp there is worth 7.4 pp overall. On lysis: 2.3.
https://t.co/cI8nuNOXsk
#Bioprocessing
Accelerate smarter upstream decisions amid compressed development timelines in this webinar hosted by Bristol Myers Squibb.
Learn how past bioreactor data guides early process optimization.
Register: https://t.co/kq0ql8cbCL
#BristolMyersSquibb #HybridModeling #Bioprocessing
What does it take to make a bioprocess reproducible from one run to the next?
Discover Multifors 3 and what it means for reproducible process development: https://t.co/XaXY2ox0Oi
#Bioprocessing #ProcessDevelopment #Bioreactor #CellCulture #TechnologyTransfer
It runs on Windows, macOS and Linux, and it’s on the Microsoft Store. There are 40 example processes, from biopharma and food to chemicals, plus a new green hydrogen plant.
Try it: https://t.co/SZ5Dv8Exz2
#ProcessEngineering #Bioprocessing #RustLang
Trypan blue counts early-apoptotic cells as viable: the membrane is still intact. Healthy culture, it agrees with flow within a few %. Day 12 of a fed-batch, it doesn't.
https://t.co/N1seVnGDO3 #Bioprocessing
5 kg Protein A batch: a 30 cm column and a 63 cm column use the same ~4,450 L of buffer. The bigger one costs 4.4x the resin and saves 20 h per batch.
Diameter is a cycle-time decision, not a buffer one.
https://t.co/XhXGqAq5k5 #Bioprocessing
Suspended Vials Help Optimize Continuous Freeze-Drying
Suspended vials and modeling with a digital twin can support fully autonomous and continuous freeze-drying
@argonne @MIT
#NextGEN #bioprocessing #lyophilization
https://t.co/b15vN2m1Wu
A $100/t carbon price adds $398/kg to a $154,762/kg mAb COGS. 0.26%.
Rank levers by abatement cost instead: 6 of 7 pay for themselves. Only a renewable tariff costs money, $67/t, for a 72% cut.
https://t.co/BB6t6uMpXy #Bioprocessing
Small Bioprocess Monitoring Hits the Goldilocks Zone
Miniaturized biocapacitance monitor hits the Goldilocks zone for small bioprocess monitors
@ost_fh @ZHAW
#NextGEN #bioprocessing #bioreactor #cellcount
https://t.co/GEYuphVI4H
HPLC robustness DOE: 4 of 6 parameters came out significant. Only pH broke the method (resolution 1.42 vs a 1.5 limit at pH 2.8).
Judge effects against the acceptance limit, not the p-value.
https://t.co/mTAZNN06en #Bioprocessing
10 L at 300 rpm to 2,000 L: constant tip speed gives 51 rpm and kLa ~3 h-1. Constant kLa needs ~128 rpm and 2.3 m/s.
Hold tip speed for shear, kLa for oxygen. They don't substitute.
https://t.co/oSIbSRuhvn #Bioprocessing
What does it take to make a bioprocess reproducible from one run to the next?
Discover Multifors 3 and what it means for reproducible process development: https://t.co/aj4F11BMXj
#Bioprocessing
Collaboration and Roadmaps Key to Capsid Accessibility
@Apertura_GTX highlights the importance of supporting collaborators to improve access to their TfR1 CapX capsid
#NextGEN #AAV #bioprocessing
https://t.co/RitUAANujr
Microbial Dark Matter Could Revive Antibiotics
Researchers propose integrated microbial discovery and bioprocessing strategies to uncover and manufacture new antibiotic candidates
@UQ_News
#NextGEN #antibiotics #bioprocessing #AI
https://t.co/qzcTes3xA5
iPSC Manufacturing Starts with the Source
@pluristyx leaders outline how better starting materials, automation, and process control can scale iPSC manufacturing
#NextGEN #biomanufacturing #iPSCs #bioprocessing
https://t.co/JtSFBk2UgV
Ultra-Low Shear Flow for Bioprocessing
#Bioprocessing #LowShear #CellCulture #Perfusion
https://t.co/i37d6NKlVB
Digital Shadows to Aid Complexity in Handling Process Intensification
Digital shadows, simpler than digital twins, can help manage nonlinear multidimensional data for process intensification
#OamaruBioSystems
#NextGEN #AI #bioprocessing
https://t.co/aXQAnCXVYN
🌱🧬 Hairy Root Mass Propagation in Bioreactors
From laboratory culture to scalable production:
Hairy Root Induction → Biomass Multiplication → Bioreactor Scale-Up → Process Optimization.
#HairyRootCulture #Bioreactor #PlantBiotechnology #Bioprocessing #BhoomiBiotechnology
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