Top Tweets for #CD69
🚨 $CRVS
New paper independently confirms #Soquelitinib targeted disruption of ITK-PLCγ1-IL-2 axis, blocking IL-2 while preserving #CD69, positions it as a precision therapy for #Th2/#Th17 autoimmunity w/ limited infection risk.
Critically, soquelitinib spares early activation events: CD69 expression remains intact, allowing initial TCR-triggered responses (e.g., costimulation and tissue retention) while blocking propagation. This "partial" inhibition promotes Th1 skewing and by sparing CD69, SQL can retain #Tregs in skin/lung for localized suppression and disease control in atopic dermatitis, asthma, etc
Phospotyrosine proteomics reveals novel Zap70 and Itk pathway targets downstream of TCR and CAR in Jurkat T cells https://t.co/EFmKPNgija #biorxiv_immuno
IL-15-stimulated #NK cells are as safe as alloreactive NK cells in KIR/HLA match #haplo_HSCT. The upregulation of #NKG2D and #CD69 might contribute to GvL effect and GvHD/TRM https://t.co/Atuu92gz7E @antonioper_mar @MestreCarmen @L4CLaPaz @CNIOStopCancer https://t.co/Atuu92gz7E
Scientists show that paired analysis of #CD69 mRNA and protein levels can help identify potent CD8 T cells with enhanced #cytotoxic effector functions within exhausted populations in tumors. @RayArja @MaxKrummel
Learn more in Science #Immunology: https://t.co/rEA3XGLwco
Another indication for $CRVS?
Paper:
- Impaired survival of CD4+ #Treg and
- "delayed deactivation of TCR signalling" indicated by elevated #CD69 expression may lead to immune dysregulation resulting in #coeliacdisease
* ITKi can reduce TCR activation signal, lowering CD69
Functional immune profiling reveals CD4+ T cell dysregulation associated with celiac disease https://t.co/uCLTeFcHmb #biorxiv_immuno
Senior Lecturer Nasu and his team identify CD69, a glycoprotein present on specific immune cells, as a new target for cancer immunotherapy
#CancerImmunotherapy #CD69 #AntibodyTherapy #AntiTumorImmunity #TumorDrainingLymphNode
@CIR_AACR
https://t.co/O5ETehst65
The expression of #CD69 #ligands in #inflammatory settings can shape the function on #immune cells
https://t.co/8Qm2laddEe explains the CD69 #receptor acts as a regulator of activation, migration, retention, #metabolism, and #T cell #exhaustion
@UAM_Madrid @CNIC_CARDIO @CIBER_CV
Thank you for the wonderful knowledge exchange during #CIMT2022 @C_IMT! Our students had a great time presenting their research on #CD69 #immunology #PET #cancer #immunotherapy
Me encuentro a @andresguerraho en un semáforo y me regala un #Guayacán de la #Siembra, lo sígo hace mucho, un hombre disciplinado, conocedor y defensor del territorio con ideas claras.
Éxitos y fuerte abrazo paisano. 🌱
#AndrésSenador 👊🏽
#CD69
@andresguerraho @AlvaroUribeVel @AlvaroUribeVel el más grande de todos los tiempos 💯 Uribista, vamos con toda #CD69 @andresguerraho @RosaAcevedoJ
#ICYMI_JI from @Masopust_Vezys @DrSaraHam @chwpeng @Lalit_Beura1 @HBorgesdaSilva and Steve Jameson | Requirement for #CD69 in generation of TRM is highly variable @umnmedschool #Tcells #ReadTheJI #immunology #FreetoRead https://t.co/HQRbgUfrhn
🎙️#AlAire | Soy de la generación que le tiene respeto a papá y mamá, estos valores se vienen perdiendo en Antioquia. La sociedad debe forjarse desde la familia #VolvamosACreer #CD69 #JuliánDiputado
Amigos les comparto un poco de la hoja de vida de mi candidato a la Asamblea de Antioquia @Beposadav #CD69 es el ÚNICO candidato apoyado por @LuisAlfreRamos
A todos los amigos que me han preguntado qué haré luego de ser precandidato al Concejo de Medellín por el @CeDemocratico apoyaré personas que quieran trabajar por Medellín y Antioquia. Los invito a votar #CD10 al Concejo y #CD69 a la Asamblea. El equipo de @LuisAlfreRamos
Invito a todos mis amigos a votar a la #AsambleaDeAntioquia por el #CD69 @Beposadav un gran profesional y ser humano, garantía que será un gran Diputado. Del equipo del ex gobernador @LuisAlfreRamos
Hier se déroulait notre assemblée générale à Mions. Merci aux membres du #CD69 et autres CD pour leur présence, à Noël GREGO (@prefetrhone) ainsi qu'à @UNASS69 et @udiom69. Merci aussi à @MPaccaud et @jmsaponara de la ville de Mions à laquelle nous avons remis un #défibrillateur.
@dodgsoncolton Sean and I love the decision, the Boolevard needs the return of #CD69
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