Top Tweets for #CGAJournalCLub
📢That's a wrap on #CGAJournalClub. Many thanks to Bryson Katona, MD and Jessica Long, MS, CGC, for participating and to all who followed along and asked questions on this important topic in #HereditaryGICancer❗️
BK-Hopefully with the new ASGE guidelines, this will improve insurance coverage for these BRCA1, BRCA2, and PALB2 carriers without a family history of PDAC! #CGAJournalClub
JL-We follow many BRCA+ women after prophylactic BLM & RRSO, who often ask about other options to mitigate HBOC-related cancer risk. After these significant risk-reducing surgeries, one of the highest remaining lifetime cancer risks is the pancreatic cancer risk. #CGAJournalClub
7⃣ Do you think that changing guidelines to remove family history requirement will increase uptake of pancreatic cancer screening among BRCA1/2, PALB2, and ATM pathogenic variant carriers? #CGAJournalClub
BK-DM screening tends to be variable in my practice, with patients getting the A1C with their annual labs with their PCP. If there was a significant jump in the A1C I would switch to q6month imaging. #CGAJournalClub
@CGAIGC Do you usually screen for diabetes at a similar time of year as the EUS or is it more patient schedule dependent? What's your next step if A1C is elevated? #CGAJournalClub
BK-If we find an IPMN with HGD in a BRCA1/BRCA2/ATM/PALB2 carrier, I would treat that as a PDAC equivalent when considering screening in other family members #CGAJournalClub
Along these lines, does your institution take into consideration fam hx of high-grade dysplasia in IPMNs for screening in BRCA1 &2/ATM/PALB2 pts? This seems to be more common as we screen more pts & find more high-grade dysplasia before malignant transformation. #CGAJournalCLub
BK-Yes, definitely! We are continuing to prospectively track all of these patients with our own institutional protocol as well as co-enrolling them in the PRECEDE and/or CAPS5 study #CGAJournalClub
#CGAJournalClub Is your institution planning to continue collecting this data prospectively for carriers of PV in all PDAC predisposition genes W/WO fhx PDAC?
BK-Great question! At this time I don't include family history of cholangioCA in my decision about offering pancreatic surveillance unless there is any uncertainty about the diagnosis with the cholangioCA (ie if the cholangio is possibly a PDAC) #CGAJournalClub
#CGAJournalClub In addition to a family history of PDAC, are there other tumor types that make you more apt to strongly consider offering BRCA1/2, ATM and PALB2 PV carriers PDAC surveillance? (e.g. cholangiocarcinoma?)
📢We are live in 5⃣ for #CGAJournalClub with Bryson Katona, MD and Jessica Long, MS, CGC to discuss and answer questions about their study: EUS-Based Pancreatic Cancer Surveillance in BRCA1/2/PALB2/ATM Carriers Without A Family History of Pancreatic Cancer. #HereditaryGICancer📢
Happening today! Excited to talk about #HereditaryGICancer and high-risk screening in @CGAIGC's #CGAJournalClub!
Didn't read the paper yet? You still have time! Great chance to ask the authors your questions!
@swatigp @priyanka_kanth @_ambreen
Join us on Twitter Tuesday May 10th at 6:30 ET for a journal club discussion with CGA members Bryson Katona and Jessica Long about their study: EUS-based pancreatic cancer surveillance in BRCA1/BRCA2/PALB2/ATM carriers without a family history of pancreatic cancer.
Reminder to follow along TODAY at 6:30 ET for our discussion about this important publication on pancreatic cancer screening in HBOC patients! Use #CGAJournalClub to participate
Join us on Twitter Tuesday May 10th at 6:30 ET for a journal club discussion with CGA members Bryson Katona and Jessica Long about their study: EUS-based pancreatic cancer surveillance in BRCA1/BRCA2/PALB2/ATM carriers without a family history of pancreatic cancer.
Don’t forget to listen to the latest CGA-IGC Podcast featuring @RachelP_LGC for further discussion on the Prospective Statewide Study of Universal Screening for Hereditary CRC from the OCCPI #CGAjournalclub (https://t.co/d6uQxJSxC2)
Any final comments? Thanks to @RachelP_LGC @HHampel1 and @DocStanich and to all who participated. We’ll be back to discuss new research soon! #CGAJournalClub
@GC_JulieMosk @CGAIGC Some of them had >1 PGV in cancer genes and we believe their CRC was due to the other gene and not the MMR gene (e.g. APC/PMS2). Otherwise, we don’t think the MSI or IHC was wrong but more that this was a reminder that LS patients can get sporadic, pMMR CRCs. #CGAJournalClub
@CGAIGC For the individuals with Lynch syndrome and MMR proficient CRC, we’re there any characteristics that differed from those with LS and MMR deficient CRC? #cgajournalclub #LynchSyndrome
@cmmuller7 @CGAIGC It’s important to identify the patients with hereditary cancer syndromes for their treatment, for their future cancer risks, and for their at-risk family members. #CGAJournalClub
@CKoptiuch @CGAIGC @HHampel1 @DocStanich Most common non-MMR genes identified were APC, ATM, CHEK2, BRCA1/2 #cgajournalclub
@cmmuller7 @CGAIGC Yes, we do. Recent studies by our colleagues @StadlerZsofia & Jewel Samadder have found that 15% of CRC patients have a pathogenic variant in a cancer susceptibility gene. Many are in genes that are actionable therapeutic targets so this can change therapy. #CGAJournalClub
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