Top Tweets for #CLDN5
Post-#stroke #reperfusion causes significant damage to BBB integrity due to low #Cldn5 expression, altering #permeability and generating #edema. Could we replace the current use of #mannitol with Cldn5-enhancing therapies and #prevent #cerebral #edema? @HaoYin20 @IntJStroke ππ§΅
#STROKE: Spatial transcriptomics of endothelial and mural cells in the peri-infarct brain cortex after ischemia stroke-reperfusion in mice suggest blood-brain barrier disruption and loss of the vascular tone. @matchkov @HalvorOG @ChrStaehr #AHAJournals https://t.co/1SQBGQsp9X
ICYMI: A #SKResearch team discovered a rare neurogenetic syndrome is caused by variants in the #CLDN5 gene.
For patients and families living with this rare condition, this marks the first time a genetic cause has been identified. #RareDiseaseDay
Read β‘οΈ https://t.co/0gI3rsKekD
Recent #SKResearch discovered variants in the #CLDN5 gene as the genetic cause of a rare neurogenetic syndrome π§ , providing an important first step towards identifying avenues for potential therapeutics.
Read β‘οΈ https://t.co/0gI3rsKekD [5/7]
ICYMI: A #SKResearch team has identified variants in the gene #CLDN5 as the cause of a rare neurogenetic syndrome. This is the first time a genetic cause can be shared with patients and families living with this rare condition. https://t.co/0gI3rsKekD
A #SKResearch team has identified variants in the gene #CLDN5 as the cause of a rare neurogenetic syndrome. This is the first time a genetic cause can be shared with patients and families living with this rare condition.
Read β‘οΈhttps://t.co/0gI3rsKMab
#CLDN5 is a new AD #MorbidGene for a NDD w/ DD, seizures (primarily infantile onset focal epilepsy), microcephaly & a recognizable pattern of pontine atrophy & brain calcifications. All dn missense variants cluster in one domain of #CLDN5 @Brain1878 π π
https://t.co/uWJUS18SYn
Hashimoto et al. identify a novel de novo mutation in the gene encoding claudin-5 in unrelated cases of alternating hemiplegia of childhood. The mutation converts tight junctions containing claudin-5 to anion-selective channels. https://t.co/wOaorwMrEN
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