#CPSF73 - Twitter Hashtag

9 days ago

Primary and metastatic colorectal tumor cells share a common origin, but do they share the same vulnerabilities? Surprisingly, primary cells depend far more on #PCF11 and #CPSF73, two pre-mRNA processing/termination factors. Our latest study explores why: https://t.co/49BrtRK4v6

DPulimamidi's tweet photo. Primary and metastatic colorectal tumor cells share a common origin, but do they share the same vulnerabilities?
Surprisingly, primary cells depend far more on #PCF11 and #CPSF73, two pre-mRNA processing/termination factors.
Our latest study explores why: https://t.co/49BrtRK4v6 https://t.co/KiCSs6kK8N

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Agata Stepien @AgataKStepien

10 days ago

4. And here's the exciting connection: Shorter distance between RNA cleavage and RNAPII terminal pausing is associated with higher gene expression and greater dependence on #PCF11 and #CPSF73. We see this relationship in pancreatic cancer cells too!

AgataKStepien's tweet photo. 4. And here's the exciting connection: Shorter distance between RNA cleavage and RNAPII terminal pausing is associated with higher gene expression and greater dependence on #PCF11 and #CPSF73. We see this relationship in pancreatic cancer cells too! https://t.co/AvlyAAgEja

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Agata Stepien @AgataKStepien

10 days ago

1. Colorectal cancer cells are highly dependent on two key RNA processing factors: #PCF11 and #CPSF73. But here’s the surprise: primary tumor cells depend on them much more than metastatic cells. Why?

AgataKStepien's tweet photo. 1. Colorectal cancer cells are highly dependent on two key RNA processing factors: #PCF11 and #CPSF73. But here’s the surprise: primary tumor cells depend on them much more than metastatic cells. Why? https://t.co/kCnhao2znG

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Agata Stepien @AgataKStepien

11 months ago

1. Colorectal cancer (CRC) cell clonogenicity critically depends on #PCF11 and #CPSF73, with primary tumor cells showing much higher addiction to those factors than metastatic cells. Why??? 🤔2/6

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