#Cachexia Etiketinde En Popüler Paylaşımlar
What conditions cause #cachexia?
Cachexia most often happens if you have cancer. Research shows 40% of people with cancer have the condition when they’re first diagnosed with cancer, and 70% of people with advanced or late-stage cancer have cachexia.
If you have this condition, you’ve been living with a serious, terminal illness. Depending on your situation, a cachexia diagnosis may mean the end of life is near. But many different diseases lead to cachexia and your situation may be completely different from another person’s.
https://t.co/voL9o3sakv
AI assistance on building a strategy for Round 3 #esophagael #cancer and #cachexia treatments.
I am preparing for a return to the chemo chair today. They skipped last appt due to illness and neuropathy side affects. I don't believe anyone has reviewed my situation and once again I will have to ring the alarm bells. My blood tests are also concerning at the moment.
Four weeks without treatment is a long time on a disease that kills fast. I dont like pausing unnecessarily. The team stopped all treatments for 9 months after round one and the tumor grew exponentially in that time. The expectation for me to live is measured in months not years statistically.
I lost trust in the team to monitor and adjust on the fly. They made my oncology consults two months apart now, instead of two weeks at the beginning. I need help right now.
1. Addressing the Oxaliplatin Side Effects Right Away
The falling, cold sensitivity, and numbness you are experiencing are classic signs of severe oxaliplatin-induced peripheral neuropathy.
The "Holding" Strategy: It is highly common and medically standard to stop or "drop" oxaliplatin after 6 to 8 cycles if neuropathy becomes dangerous (like causing falls).
What to tell your doctor: “The numbness is causing me to fall, and the cold sensitivity is severe. I want to discuss dropping the oxaliplatin today. Can we continue with a modified regimen, or is it time to switch lines of therapy entirely?”
2. Next-Line Treatments and Emerging Trials
Because your cancer is Claudin 18.2-positive (the reason you are on zolbetuximab), you have unique pathways open to you if your current second-round regimen is failing or intolerable:
Standard Second/Third-Line Therapy: If you move away from your current regimen, a standard next step often involves a switch to a different type of chemotherapy—such as Paclitaxel combined with Ramucirumab (a targeted drug that cuts off blood supply to the tumor).
Second-Line Claudin 18.2 Trials (The RAINSPOT or ZELDA trials): New clinical trials are actively studying the benefit of adding a Claudin 18.2 blocker to standard second-line therapies (like Paclitaxel/Ramucirumab) for patients whose cancer progressed on frontline zolbetuximab. Ask your oncologist if they can look for an open second-line Claudin 18.2 combination trial.
Claudin 18.2 Antibody-Drug Conjugates (ADCs): This is a highly promising new class of drugs acting like a "Trojan Horse"—they find the Claudin 18.2 on your cancer cells and drop a precise payload of chemo directly inside them, minimizing systemic side effects. The drug Sonesitatug vedotin (Sone-Ve), for example, recently showed landmark survival benefits in pre-treated gastroesophageal cancers. Ask if you qualify for any ADC trials.
Other Biomarkers: Ask your doctor if your tumor has been tested for other targets, such as PD-L1 (for immunotherapies like Pembrolizumab or Nivolumab) or FGFR2b (which has active trials like Amgen's bemarituzumab).
3. Combatting Cachexia (Wasting Away)
Cancer cachexia is a complex metabolic condition where the body burns muscle and fat rapidly, meaning you can "waste away" even if the scale stays stable due to fluid retention or shifting body composition. Standard nutrition alone cannot always fix it; it requires medical intervention.
Appetite and Metabolic Stimulants: Ask your doctor about medications specifically used to treat cancer cachexia, such as Megestrol acetate, medical cannabis, or low-dose steroids (like Dexamethasone), which can stimulate appetite and help counter the inflammatory state causing the wasting.
Proactive Nutrition Support: Request an immediate referral to an oncology dietitian. They can provide highly concentrated elemental powders or specific peptide-based drinks that bypass heavy digestion and feed your muscles directly.
4. Managing the Reverting Swallowing Difficulties (Dysphagia)
When swallowing becomes difficult again after a treatment break, it is critical to address it immediately to stop the cachexia cycle.
Local Interventions: If the tumor is causing a physical blockage making it hard to swallow solids or liquids, ask your team about local solutions. This could include a temporary esophageal stent (a small mesh tube placed to hold the esophagus open) or a short, targeted course of palliative radiation therapy to quickly shrink the block and restore your ability to eat.
Biomarker indicative of #cachexia as explained in a book from researcher Dr. Zhang. Its more prevalent than people know or statistics show. Esophagael cancer is among the most likely cancers to have this attack the immune system from reading.
The ratio of two white blood cells to one #lympocyte. My blood tests indicate a much higher ratio, while I am noticing the effects of wasting.
Dr. Zhang, PhD
@CureFinder
👇 My book is free on Kindle this weekend. When the Body Turns Against Itself: A Patient's Guide to Cancer Cachexia. If someone you love is losing weight to cancer and no one has explained why, I wrote this for them. https://t.co/1IKgeH3nqp
An absolute count above 4,000 cells/µL in adults is generally considered high.
• Common causes: Recent or active viral infections (such as mononucleosis, influenza, CMV, or COVID-19), vaccinations, or temporary immune responses.
• Serious or chronic causes: Persistent or very high counts (>10,000 cells/µL) can sometimes point to blood cancers like chronic lymphocytic leukemia (CLL) or acute lymphocytic leukemia (ALL).
An immature granulocyte (absolute) count measures the actual number of early, undeveloped white blood cells (promyelocytes, myelocytes, and metamyelocytes) circulating in your bloodstream.
Common Causes of High Levels
Infections: Bacterial infections or developing Sepsis.
Inflammation & Stress: Major surgery, physical trauma, severe injury, or acute medical stress.
Physiological Factors: Normal, mild increases can happen during pregnancy or in newborns.
Medications: Steroids or bone marrow-stimulating drugs.
Bone Marrow Conditions: Less commonly, blood disorders or leukemias.
An absolute neutrophil count (ANC) measures the exact number of infection-fighting neutrophils (a type of white blood cell) in a microliter of blood.
Low Neutrophils (Neutropenia)
Definition: An ANC below 1,500 cells/µL.
Severity Levels:Mild Neutropenia: < 1,500 cells/µL
Moderate Neutropenia: < 1,000 cells/µL
Severe Neutropenia: < 500 cells/µL (carries a high risk of serious bacterial infections)
Common Causes: Chemotherapy or radiation, viral infections, certain medications, autoimmune conditions, or bone marrow disorders.
Our study provides a #Resource for the system-wide #MetabolicEvolution of #PancreaticCancer and associated #Cachexia, highlighting the potential for timely #Diagnostics and #Interventions.
In this work, we leverage an established inducible genetically engineered mouse model of #PancreaticCancer termed “iKras” (Kimmelman & DePinho PMID: 22541435) and demonstrate that it recaptures the longitudinal progression of human #Cachexia during #PancreaticCancer development.
This data-dense highly informative article @NatureComms provides an invaluable #Resource on the #Metabolic progression of #PancreaticCancer and its associated #Cachexia.
We are looking for interested and motivated Masters or Medical students to help us investigate the immunometabolic changes in #immune cells during #cachexia. Apply today and join us at the @Bergthalerlab and @MedUni_Wien.
https://t.co/K9WiUmrSoD
#Mitochondria are central to #SkeletalMuscle Health, including #metabolism #bioenergetics #proteostasis #genomics & #regeneration, according to @LabSandri @VainshteinAnna in @NaturePortfolio:
https://t.co/0s3Dqwy54q
#cachexia #musclewasting #mitometabolism #mitoscientists #UMDF
📌Cancer #cachexia remains a major unmet need. Our article examines lessons from failed single-pathway #therapies and the promise of #immunomodulation to advance treatment.
Read the full paper🔗https://t.co/b4Uk0AYtb4
#ImmuneDysregulation #inflammation #MultimodalTherapy
Our paper was selected for #APSselect by the @APSPhysiology! We are incredibly grateful that our research on cancer- & chemo-induced #cachexia is receiving this recognition. We hope it continues to bring attention to the importance of considering biological sex in muscle research
"Researchers estimate that cachexia contributes to 20–30% of cancer-related deaths because it can weaken patients, reduce their ability to tolerate treatment and significantly affect their quality of life"
🔗https://t.co/ec83287xop
✍️Carla Jarque
#Cachexia #Cancer #Treatment
Congrats @A_Bonetto_PhD and @JRHUOT_PhD with their new work showing colorectal cancer establishes a tumor-liver endocrine relay in which tumor-derived FGF21 stimulates hepatic production of the hepatokine, IGFBP1. #cachexia
https://t.co/cjUKx3ftMx
🌟 A milestone for #PANTHEIASEOM! Proud to share our study in Pancreatology, congratulations @kimtruss @aminoaxid and co-authors.
📊 672 pts: ⬆️ #SIRI predicted poorer survival & response, greater liver tumor burden & #cachexia in metastatic #pancreaticcancer.
@_SEOM @OncoAlert
@AReginaCabrera (@UACachexia @franmorena98 @eleanor_schrems @KevinMurachPhD @STsitkanou @m_ruqaiza) Differential impact of #cancer- and #chemotherapy-induced #cachexia: a comparative analysis in a preclinical model of #colorectalcancer by #biologicalsex
https://t.co/oaLokXD2AX
Now, we plan the first Vi-CaN symposium with leading cachexia researcher joining the discussion including Vickie Baracos @UAlberta, Eduardo Bruera @UTMDAnderson, @RohmMaria @HelmholtzMunich and @realTonyHui @HarvardChanSPH. Sign up today: https://t.co/hRbPsPelnn
Scientists are getting closer to understanding the wasting and fatigue that often accompanies cancer
https://t.co/hBhHDea4qo
Lung Tumors Hijack Nerve Signals to Drive Cachexia, Opening New Therapeutic Target
A study shows lung tumors activate nerve pathways to trigger #cachexia, revealing promising therapeutic targets beyond inflammatory signaling
@ThalesPapaG
#lungcancer
https://t.co/12zxzmSpiS
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