Top Tweets for #CelMod
#BITE is an Amgen term. Hence we cannot call non Amgen #Bispecifics as BITEs. The generic term is T Cell Engagers or #TCE. Similarly #CELMOD is from BMS. What to call other drugs in the same class those are not from BMS? Cereblon-based Molecular Glue Degraders- ?CMGDs. Is Cemsidomide a #CMGD?
FDA grants accelerated approval to iberdomide (Zenbexus), BMS’s first approved CELMoD for multiple myeloma.
The approval adds a new cereblon-targeting option for patients who have received prior treatment.
#MultipleMyeloma #CELMoD #CancerResearch
#DrugDevelopment #Hematology
A Milestone as the #FDA Approves the First #CELMoD Therapy On August 13, 2026, the FDA granted accelerated approval to #iberdomide (Zenbexus) + #daratumumab + #dexamethasone for certain patients with relapsed/refractory multiple myeloma (#RRMM).
🧬Molecular Glues: A Milestone as the #FDA Approves the First #CELMoD Therapy
On August 13, 2026, the FDA granted accelerated approval to #iberdomide (Zenbexus) + #daratumumab + #dexamethasone for certain patients with relapsed/refractory multiple myeloma (#RRMM).
As a Cereblon E3 Ligase Modulator (CELMoD), iberdomide is the first FDA-approved CELMoD therapy, marking a major step forward for molecular glue-based drug discovery.
🔬Meanwhile, recent studies are expanding the molecular glue toolbox:
🔹#M12 | Nature, Aug 5
A DCAF11-dependent molecular glue expands the use of DCAF11 as an E3 ligase for targeted protein degradation.
🔹KAT2A Glue | Science, Aug 7
A new #CRBN molecular glue induces KAT2A degradation without the canonical G-loop, challenging conventional rules of target recognition.
🔹#TCIP3 | Celll, Jul 20
A bivalent molecular glue connects BCL6 with lysine acetyltransferases, demonstrating that molecular glues can create new functional protein interactions beyond conventional degradation.
✨Molecular glues induce or stabilize protein–protein interactions, offering the potential to target previously undruggable proteins. Explore MCE’s molecular glue inhibitors, degraders, controls, and molecular glue compound library to support your research. https://t.co/43DsVe1lS1
#MolecularGlue #TargetedProteinDegradation #TPD #DrugDiscovery #ChemicalBiology #CancerResearch
🚨 @US_FDA accelerates approval of Iberdomide (Zenbexus), the first #CELMoD!
Based on #EXCALIBER-RRMM
⭐️ MRD-neg CR: 41% (ZDd) vs 21% (DVd)
👉 First RRMM approval based on MRD-neg CR
✅ New option
#mmsm #MultipleMyeloma #OncTwitter #HemOnc #FDA
🔗 https://t.co/ttRyLBS7II
🚨 @US_FDA accelerates approval of Iberdomide, first #CELMoD!
Approval based on #EXCALIBER-RRMM:
⭐️ MRD-negative CR: 41% (ZDd) vs 21% (DVd)
👉First RRMM approval based on MRD-neg CR
#mmsm #MultipleMyeloma #BloodCancer #OncTwitter #FDA #BloodCancer
🔗 https://t.co/tClIt7wARl
Iberdomide (first CELMoD) now @US_FDA ✅ based off EXCALIBER-RRMM in 2L and beyond for R/R #MultipleMyeloma.
IberDd:
- Improved MRD (41% vs. 21%)
- PFS still immature
- AEs: Cytopenias and Infections
#OncTwitter #MedTwitter #HemeTwitter
La #FDA 🇺🇸 accorde une #FastTrack 🚀 à #ZENBEXUS, le 1er traitement #CELMoD de #BristolMyersSquibb $BMY 🇺🇸, en association avec le #Daratumumab, l'#Hyaluronidase et la #Dexaméthasone, pour les patients atteints de #MyélomeMultiple 🩸, dès la 1ère rechute.
https://t.co/Iyb8TpykD4
少なくとも1ラインの治療を受けた多発性 #骨髄腫 に #CELMoD である #iberdomide とダラツムマブ、デキサメタゾンの併用療法が米国で迅速承認されました。新規モダリティとして注目されるCELMoDの初承認です。日本でも早期に承認されることを期待します。
https://t.co/TIN4hHDWT0
@SagarLonialMD @MyelomaDrKapoor @MayoClinic @unmc 59) And . . . congratulations! You are not only up to date from #ASCO26 on #CELMoD therapy for #MM, you also just earned 1 hour of 🆓CE/#CME credit! Claim your certificate now at https://t.co/3p9nd2Sa9I.
Many thanks to our 🏆expert faculty @SagarLonialMD @EmoryMedicine!
@SagarLonialMD @MyelomaDrKapoor @MayoClinic @unmc 48) #Lenalidomide maintenance post-#ASCT is #SOC in #MM, but ~30% of pts d/c within 1y due to toxicity. Could #iberdomide, a more potent oral #CELMoD, offer a better-tolerated and more effective alternative? A Ph 2 trial reports its primary analysis. #ASCO2026
@SagarLonialMD @MyelomaDrKapoor @MayoClinic 42) Survival data at 22.8 months median follow-up are striking. Median #PFS not reached; 18-month PFS 88.9%. Median #OS also not reached; 18-month OS 94.5%. These are the FIRST survival data reported for a #CELMoD-based quadruplet in #NDMM.
#ASCO2026 #IDEAL #multiplemyeloma
6a) #CELMoD agents (Cereblon E3 Ligase Modulators) are next-generation descendants of #IMiDs like #thalidomide, #lenalidomide, and #pomalidomide. In #MM, they act as “molecular glue degraders,” binding #CRBN . . .
1) HELLO from #Chicago & #ASCO26! Your @onc_ce MedEd team is HERE and watching closely for new data on #CELMoD therapy for multiple #myeloma #MM. Bringing us the latest is new expert faculty Sagar Lonial @SagarLonialMD @EmoryUniversity @EmoryMedicine @WinshipAtEmory
Thought of the day at #ASCO26
SUCCESSOR-2 + MAJESTEC-9 = the age of immune dominance in myeloma !
From SUCCESSOR to MAJESTEC, immunomodulation empowers immunotherapy !
@TheIACH @COMyCongress
#Immunotherapy #CELMoD #Bispecifics
Le traitement du #MyélomeMultiple 🩸 évolue vers un avenir plus ciblé.
La #FDA 🇺🇸 a accepté une demande de médicament pour l’#Iberdomide, un #CELMoD de 1er ordre qui, combiné à #Darzalex et #Dexaméthasone, offre une nouvelle stratégie pour les patients R/R
https://t.co/pUeBv3nPMk
Article✍️Rational engineering of #degradation tail-driven #CELMoD–#antibody #conjugates for #precision #malignancy #therapy. From Dr. Dong @ZhejiangUniversity;
https://t.co/1JvCmOkbG9.
#RRMM 1-3 pLOT, MagnetisMM-30 evals #BCMA-directed Elrexfio and #CelMod Iberdomide. Early results show efficacy in non-BCMA xposed. Infection, CRS & ICANS manageable. IVIG allowed. #ASH25 #mmsm @IMFMyeloma #IMFASH25 @ASuvannasankha
Teclistamab not working? Add a CELMoD twist!
Dr. @MalinHultcrantz explores teclistamab+ mezigdomide combo to fight T-cell exhaustion & BCMA escape in RRMM
Trial opens May 2025-Watch this space!
#Myeloma #CELMoD #DAVAWhistler
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