Top Tweets for #ClinicalPathologicChallenge
#ClinicalPathologicChallenge
71F with painless nodule on the lower lip
H/E: Well-circumscribed nonencapsulated tumor composed of bland spindle cells in a collagenous stroma with a prominent, branching (“staghorn”) vascular pattern.
IHC:- B: CD34, C:S100, D:SMA, E and F: STAT6
#ClinicalPathologicChallenge
4YM born to nonconsanguineous parents, presented with a 4-month history of numerous brown papules involving the trunk, extremities, and face.
Patient had high myopia causing strabismus.
F/H neg
What is your Dx/Differential Dx?
#ClinicalPathologicChallenge
63F with known Darier disease (DD) presented to the ED after 1 week of fevers, gastroenteritis, and rapidly progressive skin blistering and desquamation.
P/E: Diffuse epidermal sloughing with hemorrhagic crusting on the vermillion border
#ClinicalPathologicChallenge
66YM with poorly controlled diabetes mellitus p/w a sinus-forming polypoid firm nodule on the right scrotal skin. It was slightly tender and oozing yellow paste-like debris material from the surface openings.
IHC: CK5/6 in Fig 4(A,B,C), SMA in Fig 4D
#ClinicalPathologicChallenge
68YF with a slowly growing painful lesion involving the right breast with associated skin peeling.
Past M/H: early-stage invasive ductal carcinoma of right breast treated with lumpectomy and local radiation therapy
Dx?
#ClinicalPathologicChallenge
10-year-old boy presented with a painless, mobile subcutaneous nodule on his left anterior knee x 1–2 years
Key H&E: lobular proliferation of atypical spindle cells surrounded by a thin capsule with pericapsular lymphocytic cuffing.
#ClinicalPathologicChallenge
77YF with a h/o Hodgkin lymphoma presented with a 4-month history of burning palmar and plantar plaques
Figure 3: (A) CD3, (B) CD4, (C) CD8, (D) CD7
CD30 was negative
#ClinicalPathologicChallenge
58YF p/w 3 asymptomatic red skin lesions over the forehead that appeared 2 weeks after botulinum neurotoxin injections for rhytids
H/P: increased upper dermal vascularity with focal fibrosis and scattered interstitial angulated multinucleated cells
#ClinicalPathologicChallenge
50YF p/w purple to black macules on her right ear
1. An 8-mm irregular brown thin plaque on the right superior helix indicated by the blue arrow [Fig 1: E. Melan A and F. PRAME]
2. a 4-mm gray-blue macule on the upper right posterior helix
![AJDP_Journal's tweet photo. #ClinicalPathologicChallenge
50YF p/w purple to black macules on her right ear
1. An 8-mm irregular brown thin plaque on the right superior helix indicated by the blue arrow [Fig 1: E. Melan A and F. PRAME]
2. a 4-mm gray-blue macule on the upper right posterior helix https://t.co/MKfRjUyGZL](https://pbs.twimg.com/media/GjCaHNgWoAEOUEy.jpg)
![AJDP_Journal's tweet photo. #ClinicalPathologicChallenge
50YF p/w purple to black macules on her right ear
1. An 8-mm irregular brown thin plaque on the right superior helix indicated by the blue arrow [Fig 1: E. Melan A and F. PRAME]
2. a 4-mm gray-blue macule on the upper right posterior helix https://t.co/MKfRjUyGZL](https://pbs.twimg.com/media/GjCaHNfWgAAR-9p.jpg)
#ClinicalPathologicChallenge
33YM presented with multiple erythematous–violaceous non-follicular papules and macules up to 6 mm in diameter symmetrically distributed on trunk and extremities x 2 years
What's your diagnosis?
#ClinicalPathologicChallenge
15YF with 2-year history of diffuse hair loss and “woolly” hair.
No h/o mental illness
No signs of inflammation or scarring
What's your diagnosis?
#ClinicalPathologicChallenge
43YM, smoker, with h/o Crohn disease p/w asymptomatic, infiltrated erythematous ulcerated nodules on the dorsum of his left hand & on anterior right & left thighs
Fig 3: (A)CD3 (B)CD20 (C)CD4 (D)CD30 (E)CD68 (F)CD8 (G)Kappa (H)Lambda
What's your Dx?
#ClinicalPathologicChallenge
60yM presented with nonhealing painful ulcer over hard palate associated with odynophagia, and erythematous plaques and crusted erosions over trunk and thighs.
What is your diagnosis?
#ClinicalPathologicChallenge
16Y/M with 1.2 cm diameter elevated skin lesion on the scrotum, transillumination +
During the surgery, the lesion was observed to be extending to the testis and attached to the tunica vaginalis.
IHC: (C) ER, (D) PR, (E) CEA, (F) EMA, (G) PanCK
Dx?
#ClinicalPathologicChallenge
20F presented with a 2-year h/o pruritic erosive lesions on her lower lip that occur in spring and early summer. On physical examination - enlarged erythematous lower lip with tiny erythematous papules and crusts.
What's your Dx?
Any IHC?
#ClinicalPathologicChallenge
34M with PMH of MDS presented with fever and several crusted vesicles on the shaft of the penis and mons pubis with a surrounding large pink edematous plaque.
Repeated HSV/VZV swabs were negative.
What's your diagnosis?
Additional investigation?
#ClinicalPathologicChallenge
60F with a strong family history of breast cancer presented with erythematous papule without surface change on the inferior aspect of the left areola
IHC: (A) CK7, (B) Her-2
What is your diagnosis?
Any additional stains you'd like to perform?
#ClinicalPathologicChallenge
59F with PMH of type 2 diabetes mellitus and end-stage renal disease presented with pruritic purple–brown papules and polymorphic plaques with an erythematous rim after a hemodialysis session
What is your diagnosis?
#dermatopathology #PathTwitter
#ClinicalPathologicChallenge
submitted by @gerardo_cazzato
78F p/w
(A) itchy and painful erythematosus patches on the legs
(B) Histiocytes engulfing neutrophilic granulocytes in karyorrhexis, lymphocytes, and erythrocytes
(C) IHC - CD163
What's your diagnosis?
#ClinicalPathologicChallenge
50F presented with a 1.2-cm diameter nodular ulcerated lesion on the anterior plantar surface of the left foot x 3 years
IHC: S-100 (C and D)
What's your diagnosis?
Most Popular Users
Elon Musk 
@elonmusk
241.5M followers
Barack Obama
@barackobama
119M followers
Cristiano Ronaldo
@cristiano
114M followers
Donald J. Trump
@realdonaldtrump
111.8M followers
Narendra Modi
@narendramodi
107.2M followers
Rihanna
@rihanna
98.6M followers
NASA
@nasa
92.4M followers
Justin Bieber
@justinbieber
91.8M followers
KATY PERRY
@katyperry
89.8M followers
Taylor Swift
@taylorswift13
83.7M followers
Lady Gaga
@ladygaga
75.2M followers
Virat Kohli
@imvkohli
72.9M followers
Kim Kardashian
@kimkardashian
70.8M followers
YouTube
@youtube
68.8M followers
Neymar Jr
@neymarjr
65.9M followers
Bill Gates
@billgates
64.9M followers
Selena Gomez
@selenagomez
62.8M followers
The Ellen Show
@theellenshow
62.3M followers
CNN
@cnn
61.8M followers
X
@x
60.7M followers