Top Tweets for #ClosedSystems
🔗 $NWBO #DCVax #Eden FIGURE 4 — When Expansion Becomes Part of the Therapy
#CellTherapy #TCellExpansion #Biomanufacturing #ClosedSystems #GMP #ProcessEngineering
FIGURE 4 answers a question that most expansion platforms never confront: where does expansion actually sit in the therapy?
This figure places expansion inside a closed, end-to-end clinical loop:
• cell collection
• cell separation
• cell expansion
• washing and concentration
• formulation
• cold chain
• reinfusion
Expansion is not shown as an isolated laboratory step. It is shown as a node in a continuous circuit with defined inputs and outputs.
That framing matters.
When expansion is treated as a standalone step, variability is tolerated and corrected downstream. When expansion is embedded in a closed loop, variability becomes exposure. The history of how cells were handled becomes part of what the patient receives.
Several implications are built into FIGURE 4:
• Exposure is defined by process, not just by dose.
• Each transition is explicit, not inferred.
• Cells move through stages with documented transformations.
• The system enforces continuity from collection to infusion.
This is not simply about logistics or compliance. It is about interpretability.
If cell fate is shaped upstream, then outcomes downstream can only be understood if the upstream process is stable and traceable. FIGURE 4 makes that stability a design requirement.
Another subtle but important point: FIGURE 4 does not assume genetic modification. It allows for optional branches, but the core logic stands without them. Expansion is treated as a primary determinant of behavior, not a secondary amplification step.
By closing the loop, the system turns expansion into a repeatable intervention rather than an artisanal procedure. Cells are not just grown; they are processed through a sequence whose structure can be reproduced.
FIGURE 4 also clarifies why the earlier figures matter. The chamber geometry in FIGURE 2 and the motion control in FIGURE 3 are not isolated optimizations. They are prerequisites for a loop in which each run must be comparable to the last.
When expansion is part of a closed loop:
• uncontrolled drift cannot be ignored
• ad-hoc corrections are not acceptable
• the process itself becomes the product
FIGURE 4 is the moment where expansion stops being “how many cells did we get?” and becomes “what experience did these cells undergo?”
That shift is foundational.
If FIGURE 1 defined expansion as a system,
and FIGURES 2–3 defined how that system shapes cell behavior,
FIGURE 4 defines why expansion must be reproducible to be meaningful at all.
for individual hardware owners to contribute to a global network. #InnovationBottleneck #ClosedSystems.
This and many more were the state of tech before @cysic_xyz .
Time will not permit me today to share ALL, however the game changer is what you should pay more attention to.$CYS
Open Source vs Closed Systems: Which Standard Will Win in the Battle for AI Supremacy?
@meta #Meta #Llama31 #AI #ArtificialIntelligence #OpenSource #ClosedSystems
We're exhibiting at @CSCAssociation event in London focused on all things associated with managing #waterquality in #closedsystems
Andre de Bache, Product Manager for #BoilerWater & #ClosedSystems, participated last week at the #vgbe Chemistry Conference 2022 in Dresden and presented “Kurita Dropwise Technology: Efficiency improvement in #powerplant condensers.”
Download here ➡️ https://t.co/LzUdv45waA
Could you #Feature in the #Next Waterline?
We are preparing the #Autumn 2022 issue and we are #Looking for features in the following topics: #ClosedSystems, #RemoteMonitoring and #WaterChemistry.
Do you have something to #Share with our #Readers?
Email us: [email protected]
Could the preservation and growth of that #evergreen in turn help North Africa? #JustAThought #IKowNothing #Cicles #Questions #Green #earth #climate #homeostasis #closedsystems
The Human Body is comprised of Several Systems working together in a Closed Loop and programmed to preserve life.
#ClosedSystems #BiomedicalDigitalTwins #Bioinformatics
Kurita's Cetamine® Technology provides excellent protection against corrosion in #BoilerSystems, #SteamGenerators and #ClosedSystems.
Based on surface-active film-forming substances a protective Cetamine®-film is formed on all system surfaces.
➡️ https://t.co/TeVupLLKw4
Learn how we can help keep clinicians safe from hazardous drug exposure and meet industry safe handling guidelines. For more details, join us during the UK Oncology Nursing Society’s annual conference. #UKONS #NHS #chemo #CSTDs #ClosedSystems #AcuteOncology
Don’t forget to register for Friday’s Pharmacy Purchasing & Products to The Point series webinar and learn how #CSTDs can enhance the safety and efficiency of #oncology IV therapy. Register at https://t.co/LyhEVlw5qe.
#chemo #ClosedSystems #pharmacist #OncoPharm #pharmacy
#HazardousDrugs #SACT #Drugs #Chemotherapy #Oncology #Nurse #Health #Safety #Protection #Healthcare - how are #Nurses at risk? Learn more here https://t.co/1VYan6Kzdv - #PPE #ClosedSystems #SafeHandling #Clinical #waste #containment #transport #incineration in #Pactosafe
Join ADEY’s head of training Colin Yearp and Regional Commercial Manager Mike Green for an overview of commercial filtration options on Thursday 21 January.
https://t.co/NZevjJJA8f
#askadey #sealedsystems #closedsystems
Nous soutenons cette proposition de @medtechinfrance L’inclusion dans la nomenclature de certains systèmes permettant de protéger nos soignants, tels que #Qimono, pourrait avoir un impact économique positif à plusieurs niveaux. #closedsystems #CSTDs #Cancer
🏆La France, leader mondial des technologies médicales ? C'est possible, voici le parcours idéal en 13 étapes.
⏳ Etape 6 : réviser les nomenclatures, merci @VygonGroup @EDAPTMS et @maunakeatech.
🎯L'ensemble de la mesure sur https://t.co/FsQZuAtYN7.
#MedTech #santé #PlanDM
Coming soon!
Get in touch - [email protected] or 0345 605 0405
#environmentallyresponsible #coolingtowers #closedsystems #sustainability #madeinbritain #watertreatment #getintouch #solidtek
2021 training dates now available to #BookNow.
Start the new year with some new knowledge in all types of #WaterSystems: #LegionellaControl, #CoolingSystem, #SpaPool, #Chemistry, #WaterHygiene, #PseudomonasAeruginosa #ClosedSystems.
https://t.co/dLg5ICdAuk
Simon Hughes delivering our #Management and #Control of #Closed #Systems #Training #Course #Today!
#WeAreOpen for #Real #FaceToFace training, with #Plenty more courses #Scheduled for the remainder of the year:
https://t.co/dLg5ICdAuk
#WaterTreatment #ClosedSystems #CityAndGuilds
Göteborg, 2009. Sexpositive schwedische (!) Wissenschaftlerinnen bringen mir beim WAS-Kongress die Vokabel „Fascho-Feminismus“ bei: der schwedischen Kommunitarismus ächtet Prostitution so komplett, dass feministische Diskussionen völlig eindimensional werden. #closedsystems
my #review
Spaceship Earth
Biosphere 2 #closedsystems performativity https://t.co/L0qbFKaJKi
https://t.co/hvFQf9ZAbW
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