Top Tweets for #DiseaseWeek
Focal and Diffuse Lupus Nephritis #DiseaseWeek
The photomicrograph above shows three glomeruli, all with endocapillary proliferation and one showing a nascent cellular crescent. These findings are seen in proliferative lupus nephritis.
Time for another #DiseaseWeek challenge question!
Which of the following lupus classifications can be seen in the same biopsy?
50% of adults with SLE will develop lupus nephritis. In children with SLE, 80% have nephritis. In a majority of cases, renal involvement in SLE often occurs in the first year following diagnosis, but can occur at any time in the disease course. 🧵
#LupusLesson #DiseaseWeek #Renal
Time for a #DiseaseWeek challenge question!
What proportion of adult patients with SLE have nephritis?
Time for a #DiseaseWeek challenge question!
What proportion of adult patients with SLE have nephritis?
It's #DiseaseWeek at Arkana – let's learn about lupus nephritis!
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which affects over 5 million people worldwide. The evaluation of lupus disease activity utilizes a point system where different disease manifestations are assigned different point values, and a score of 10 is required for a diagnosis of SLE. Under this scoring system, a diagnosis of focal or diffuse lupus nephritis is sufficient for a diagnosis of SLE in patients with a positive antinuclear antibody (ANA) test. #LupusLesson #Lupus #Renal
While renal and urinary involvement in IBD is not uncommon, renal parenchymal disease is rare and most commonly affects the glomerular and tubulointerstitial compartments. #DiseaseWeek #NephTwitter https://t.co/VUr3TpCFpB
The most common renal manifestations in the pediatric IBD population with renal manifestations was nephrolithiasis (58%) followed by TIN (30%), which was present in two-thirds of UC pts. #DiseaseWeek
https://t.co/yvH4ROhhLf
A recent literature review of the pediatric IBD population with renal manifestations found a strong predilection in boys (72%) and those with Crohn disease (80%). #DiseaseWeek https://t.co/yvH4ROhhLf
Although the frequency of renal involvement in pediatric IBD is not well described, there have been several reports of nephrolithiasis, GN (particularly IgAN), TIN, and rarely AA amyloidosis. #DiseaseWeek
https://t.co/SLM18nb0vK
https://t.co/nEFIAsfRza
Interestingly, granulomatous TIN has been reported in drug-naïve patients with Crohn disease. This suggests TIN may actually represent a true extraintestinal manifestation of IBD in certain patients. #DiseaseWeek
https://t.co/sWEiAIedF5
There have been several case reports of both acute and chronic (TIN) occurring in patients with both Crohn disease and ulcerative colitis, particularly in the setting of 5-ASA drug therapy and its derivatives. #DiseaseWeek
Acute tubular injury and tubulointerstitial nephritis (TIN) have been reported as both an extraintestinal manifestation of IBD as well as a complication of IBD-related therapy. #DiseaseWeek
https://t.co/iHpilUMwbg
How much do you know about renal manifestations of inflammatory bowel disease (IBD)?
Follow along this week as Dr. Ambruzs discusses the extraintestinal manifestations, morphologic patterns, and the most common findings on renal biopsies of IBD patients. 🔬 #DiseaseWeek
MGRS-associated diseases or lesions are predominantly classified according to the characteristics and texture of the monoclonal deposits.
Thanks for following this #DiseaseWeek! #MGRS #renalpath https://t.co/MAGXTO1DOw
A small subset of cases of membranous glomerulopathy is caused by monotypic deposits. We propose the following algorithm for evaluation of such cases: https://t.co/wGWZkiMT3w
#DiseaseWeek
Biopsies that would otherwise meet diagnostic criteria for IgAN are rarely caused by monoclonal IgA deposits and fall within the spectrum of MGRS-lesions. Therefore, these patients may benefit from clone-based therapy. #DiseaseWeek
https://t.co/aksilyBz63
Even though an underlying monoclonal Ig or an identifiable clone is detected in only 30-40% of patients with PGNMID, these patients significantly benefit from proven or empiric clone-specific directed therapy. #DiseaseWeek
https://t.co/R6op29QxVE
If left untreated, patients with PGNMID may progress to ESRD and more than 80% of post-transplant patients will have recurrent disease, with the majority developing the disease within 4 months from the date of transplant. #DiseaseWeek
https://t.co/MWgd7FynPo
Typical of adults (mean 54.5 yrs), PGNMID is also reported in children. None of the reported pediatric cases has been associated w/ underlying hematologic disorders; therefore, it remains unclear if the pathogenesis is the same as in adults. #DiseaseWeek
https://t.co/DiqmSvD0gw
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