#Dppa2 - Twitter Hashtag

over 4 years ago

What restricts #intergenerational transmission of #epialleles in #pluripotent cells? @PearLady0 @CristinaPolica4 @hackettlab @EMBLRome identify both naive #pluripotency and #chromatin protein #Dppa2 as gating factors https://t.co/LuuglCOhgj

embojournal's tweet photo. What restricts #intergenerational transmission of #epialleles in #pluripotent cells?
@PearLady0 @CristinaPolica4 @hackettlab @EMBLRome identify both naive #pluripotency and #chromatin protein #Dppa2 as gating factors
https://t.co/LuuglCOhgj https://t.co/Qlsirp62Pl

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Reik Lab @ReikLab

over 5 years ago

They find that induced #heterochromatin (using epigenetic editing) isn't stable in naive #stemcells but can be upon #differentiation. Knockout of #Dppa2 (one of our favourite genes too!) permits epigenetic inheritance of #epialleles. (2/3)

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Celia Alda-Catalinas @CeliaAlda9

about 6 years ago

Finally, we show that #Smarca5’s regulation of #ZGA-like #transcription in #ESC is dependent on its #ATPase activity and on #Dppa2 (6/6)

CeliaAlda9's tweet photo. Finally, we show that #Smarca5’s regulation of #ZGA-like #transcription in #ESC is dependent on its #ATPase activity and on #Dppa2 (6/6) https://t.co/4RnjEsZ54t

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Celia Alda-Catalinas @CeliaAlda9

about 6 years ago

We validated our #screen approach and some of the #hits identified using arrayed #CRISPRa followed by bulk #RNAseq and also followed-up #Patz1 #Smarca5 and #Dppa2 using #cDNA #overexpression experiments (5/6)

CeliaAlda9's tweet photo. We validated our #screen approach and some of the #hits identified using arrayed #CRISPRa followed by bulk #RNAseq and also followed-up #Patz1 #Smarca5 and #Dppa2 using #cDNA #overexpression experiments (5/6) https://t.co/imvepI0jWU

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Celia Alda-Catalinas @CeliaAlda9

about 6 years ago

Using this #ZGA signature identified by #MOFA, we uncovered 24 genes whose #CRISPRa induced #ZGA-like transcription. These are our #screen #hits, which include #transcription and #chromatin factors such as #Patz1 and #Smarca5 and previously known regulators such as #Dppa2 (4/6)

CeliaAlda9's tweet photo. Using this #ZGA signature identified by #MOFA, we uncovered 24 genes whose #CRISPRa induced #ZGA-like transcription. These are our #screen #hits, which include #transcription and #chromatin factors such as #Patz1 and #Smarca5 and previously known regulators such as #Dppa2 (4/6) https://t.co/jDtLirtpKe

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Inti De La Rosa Velazquez @IntiOmics

about 6 years ago

Las #proteinas #Dppa2 y #Dppa4 protegen zonas del #genoma conta la #DNAme de novo. #epigenoma #Transposons #bivalencia #epigenetica #H3K4me3 Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development https://t.co/O7xEAGoJBo

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Celia Alda-Catalinas @CeliaAlda9

about 7 years ago

Excited to share our recent work. #CRISPRa coupled to #scRNAseq to uncover new epigenetic regulators of zygotic genome activation. A great collaboration with @gtcaa and @OliverStegle. @ReikLab @meleckmas @oana #CRISPR #singlecell #zga #Dppa2 #Smarca5 https://t.co/kMzAENBWEi

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EpiCSA @EpiCSA01

almost 8 years ago

RT @meleckmas: PAPER ALERT! Our #preprint on the role of #Dppa2 and #Dppa4 in regulating zygotic transcriptional programmes is online! @biorxivpreprint @ReikLab @CeliaAlda9 @ChristelKrueger #epigenetics #stemcells #dnamethylation #transcription … https://t.co/j2jsZc2zLd

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Celia Alda-Catalinas @CeliaAlda9

almost 8 years ago

#Dppa2 and #Dppa4 in early mouse embryogenesis. #zga #development #preprint @ReikLab @meleckmas @ChristelKrueger https://t.co/YLP0gq70L5

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