Top Tweets for #ENDOORAL
During #EndoORAL trial presentation #ESCMIDGlobal2026, a key question was raised: was cardiac imaging (echo /TEE) performed before switching to oral therapy as per ESC 2023 recommendations?
The presenter replied: no, it was not routinely done! #idxposts

In today’s #EndoORAL trial presentation, a key question was raised: was cardiac imaging (echo /TEE) performed before switching to oral therapy as per ESC 2023 recommendations?
The presenter replied: no, it was not routinely done! @BradSpellberg @DrToddLee #ESCMIDGlobal2026
▶️The ENDO-ORAL Cohort study
Should we extend the use of oral antibiotics in infective endocarditis?
#ESCMIDGlobal2026 #IEWiki

https://t.co/LrL9PBTbet
#IE のOral switchについての #ENDOORAL #IDSA
この論文自体は、観察研究。加えて治療レジメンの不均一性などのバイアスのリスク、HRの95%CIは広い(0.26–1.17)などの問題あり。
基本的には、現時点でのプラクティスは変えない。仮説生成段階の論文。今後のRCTに期待。
ただ、どーしても訳アリの「早期に自宅に帰りたい事情のある」IEで、「S.aureusでない」、かつ、私の地域みたいにOPAT が現実的ではない地域だったら、10日のDIV後に早期内服スイッチも考慮…することも…ある…かも。
(でも、連鎖球菌なら、PCG感受性次第だけど、だったらGM併用したら、短期治療レジメンがあるので…。連鎖球菌でPCGのMICが少し高いケースで…みたいな患者層がよいのだろうか。もっと待たないとわからないけれど)
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