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#GameChnager out 🤣🤣🤣
#Irumudi 10 Days Total WW Collections!
Super Sensational!!

@dustysayz @T2BLive #GameChnager ki Hindi lo collections vachayee
#Peddi ki Telugu lo vachayee
Logic undadu 🗣️🗣️🗣️
#Peddi
March 27th
Wishing our beloved Mega Powerstar @AlwaysRamCharan a very happy birthday ❤️
Keep slaying with your majestic presence
#HBDRamcharan
#HappyBirthdayRamCharan
#RamCharan
#RamCharanBirthdaySpecial
#RamCharanBdayCDP #RamCharanBdaySplCDP
#GameChnager @tarak9999

Thank You #Grok
#Coolie #Pushpa2TheRule
#War2 #GameChnager
#LokeshKanagaraj | #Rajinikanth | #NTR | #HrithikRoshan | #Nagarjuna
The claim of Game Changer's 285 Cr+ Day-1 worldwide gross is inflated; reliable sources like Sacnilk report ~80 Cr actual, far below India's record (Pushpa 2 at ~295 Cr). For and , clashing Aug 14, predictions suggest Coolie could open at 140 Cr+ WW, while War 2 aims for 100 Cr+, depending on buzz and reviews.
Final advance sales :
#GameChnager Tel : $1.2M
#War2 (Tel) : 387,289
Ippudu aardam ayyi untadi evadi range ento☺️
#War2 USA Premiere Final Advance Sales🇺🇸:
$562,493 - 724 Locations - 1879 Shows - 21512 Tickets
Total North America Premiere Advances at $630K. Trending towards a 850K premiere day unless Hindi walkins give a significant push and could potentially touch the $1M mark. Pretty underwhelming advance sales given the star power and sequel. Over to the talk now. Premieres tomorrow!

GN fam 🌌
How was your day?
Whether it was wins or lessons,
you showed up, and that’s what matters.
Rest. Tomorrow, we go again.
#Web3 #GN #BuildersMindset #Ari #Arichain #Gamechnager
$NWBO #NWBO #DCVax
“I’m NOT an Oncologist, but…”
I am a hospitalist. I’m also no biotech CEO. But I am a front-line witness to heartbreak, hope, and healing. I work - a lot. I realistically see over 5,000 patients a year (271 shifts last year and counting). I did my entire medical training during COVID from beginning to end. My grandfather died of esophageal cancer. My father has pancreatic cancer. So yes, I think I know a thing or two about loss.
But I also think I know a thing or two about hope when I see it, too. I can remember medical school stories from some of my older mentors talking to me about when beta-blockers were first invented, that even the Cardiologists didn’t know much about them. But every now and then, something comes along that changes the entire equation in the standard of care.
DCVax-L is no ordinary therapy. Phase III trial results demonstrate increased median overall survival, 5-year survival, and statistical significance. That’s not incremental, that’s meaningful. It means lives are extended. Time is granted. Wishes and prayers are answered. And it has virtually no side effect profile, if any. That means that the cost of time is not a price paid in functionality, or the trepidation of a treatment that might be just as bad, or worse, than the disease process itself.
Some analysts estimate with recent news and legislation, there is an 85-95% chance of approval by the MHRA. The FDA: while a more conservative estimate, there is a strong efficacy signal and no safety concerns, and approval odds sit at around 60-75%. Personally, I believe that approval is not a matter of if, but rather a matter of when. I believe that approval bodies know just how monumental this change is, and that they are doing their due diligence, carefully and cautiously, to ensure that it is done correctly. I believe in the Powers that be (pun intended). You don’t fight tooth and nail for every grueling, painstaking yard just to fumble in the end zone. Patience is key, and good things come to those who wait.
NWBO is no longer a fringe story, it’s an inflection point in immunotherapy for solid tumors. It isn’t just hype, it’s truly science with soul. And when it’s approved? It won’t just extend lives; it will redefine what’s possible for brain cancer patients who have been told there is nothing left to try. And that’s just the tip of the scalpel. Imagine what the future holds with further expansion. All solid tumors. Congestive heart failure. HIV. Autoimmune conditions. Alzheimers. The sky's the limit, and the only questions we might be asking in years to come is, “Why not?” and “Why didn’t we do this sooner?”
I understand others may not be as optimistic as I am. There isn’t just doubt, there’s confrontation. And I honestly do not understand why. If you’re not for it, that’s okay. Don’t buy it, don’t support it. But the vitriol? The hostility? The bizarre, obsessive anger for a potential cancer therapy? If you’re vehemently against it… Well, I can only surmise that it says something about your character and says a lot more about you than it does about the science.
“BuT tHe tRiAL uSeD eXteRnal CoNtrOL aRmS! ThE tRiAL diDn’T uSe a RanDOmiZeD cOnTRol gRouP!”
The FDA has issued clear guidance in orphan diseases like glioblastoma, and such methods are indeed acceptable when randomized trials are unethical. Randomization isn’t a religion, it’s a tool. When patients are dying and crossover is humane, you adapt. But hey, let’s not let ethics or patient lives get in the way of cynicism.
“ThE CoMPaNy’s BeEN aROunD foR 20 YeARs anD sTiLL nO FDA aPproVal! ThAt SaYS iT aLL!”
So has cancer. Time alone doesn’t invalidate progress. It often requires it. DCVax-L isn’t racing to market, it is literally paving a brand new road through immunotherapy for solid tumors. This path is likely significantly longer because it leads to somewhere truly revolutionary.
“ThE sTocK iS sO cHeAp! IF iT wAS sO gReAT thEN iT wOuLd bE wOrTH mOrE!”
Apple was once $2, Amazon was $0.07, and BitCoin was once for computer nerds trading it for video game swords and some poor sap that bought what is now the most expensive pizza known to man. Let’s not forget why (allegedly, but come on) the price is so low right now. NWBO isn’t a meme, it is unknown and misunderstood. Science moves slower than speculation, but when it catches up? Let’s just say that valuation adjusts with interest.
“If iT rEaLLy wOrKed, BiG pHaRma wOulD hAVe bOuGhT tHem bY nOw!”
And yet, the Wright Brothers flew without Boeing. True innovation of this magnitude does not wait for buyouts, it forces them (or makes them wish they had). Once the MHRA and other agencies move, Big Pharma will either knock or be left behind.
“THeY’Re jUsT tRYing to rAIsE mOrE MoNEy! THiS iS a PumP! YoU’Re jUsT biASeD bEcAuSe YoU’rE iNveStEd!”
Ah, yes. Because all late-stage biotech companies fund global immunotherapy development from couch cushions and spare change. If raising capital for a cure for cancer bothers you, I’m afraid that we differ on a lot more than investment strategy. I can’t fix a broken moral compass, even with expert guidance and a very clear sky. I sleep very comfortably and soundly at night knowing that my investment is in a cure for cancer, that it’s scientifically proven to be effective, and saves lives. Even if it should fail spectacularly and I lose everything, at least I fought for something worthwhile. Can you say the same?
Scoff at me if you want. Spam the comments if you feel like that helps you. Call out the credentials of a Physician saving lives daily in an Emergency Room for internet points in an echo chamber of a few sad and depraved nobodies. But when the approvals come, just remember; You weren’t just late to the table, you were mocking the fire while we were carrying the torch.
Doubt all you want. We’ll be busy saving lives.
We're close, and we all know it. Tick, tock...

GMari guys... What have I missed so far these two days?
Meanwhile, my friend @phocus__t says we should be having fun... This is what came to mind...
A reminder for you to touch grass today
#ArichainUnfiltered #Gamechnager #MuitiVM #Arichain

@TrackTwood #Devara Nizam include Gst 62 cr untai ee loafer gadu 55 vesadu ippudu #gamechnager 14 cr closing untai 19 anta🤣🤣

#GameChanger Tadipatri Day7 Gross-73k 👍
1st Week Town Gross-20.59L🔥💥🔥💥🔥💥🔥
#2025Pongal
#VZMBoxOffice
Day 1 Town Gross
#GameChnager- 56,47,892-00
#DaakuMahaaraaj - 23,27,030-00
#SankranthikiVasthunnam -30,50,962-00

సంక్రాంతి విన్నర్ ఎవరు...? ఎగిరే పతంగ్ ఎవరు..?
#Sankranti2025 #Sankranti
#GameChanagerReview #DaakuMaharaajReview #SankranthikiVasthunamReview
#gamechnager #DaakuMaharaaj #SankranthiKiVasthunnam
#RamCharan #Balakrishna #Venkatesh
https://t.co/5mXG8bGC7O
#Venkatagiri , Nellore Dt
#DaakuMaharaaj advance full 🔥🔥🔥
#Gamechnager 40 % ( inc Blocked Seats )
B & C centers lo Daaku overflows valla collections vasthunnai GC ki 👍
#NandamuriBalakrishana


@DhonifiedRebel Me aukat ae ledhu ra comment cheyataniki
ABO - poster
Kalki - 170 - 191 - 21cr difference
Pushpa - 275 - 294- 19cr difference
So kutha musukondi. WW oostharu ippudu chudu. Aina #Gamechnager >> #Salaar oppeskunnaru ga

Tadipatri
#Devara Day 1-27.75L 💪💪
#Gamechnager Day 1-10.60L 🤣🤣🤣
Day 1 Ma collections lo 40% kuda levu kada raa
#DisasterGamechager
https://t.co/5Ig9BBAzZc Kiara Advani
#kiara #KiaraAdvani #KiaraAdvanihot #gamechnager #kiaraadvanihot #Gamechanger #GameChanger #BlockbusterGamechanger
#BlockbusterGameChanger
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