Top Tweets for #Gsdmd
Cytoplasmic cleaved #GSDMD in live activated macrophages and #DLBCL cells marks cognate interactions and predicts better patient survival. Read in Blood Advances: https://t.co/ytKtvAV1yV #BloodAdvances
Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy
🚨 Featured in eGastroenterology Vol. 3, Issue 1 – Cover Article
🔥 Original research: Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF
👉 Stay tuned for more highlights in the upcoming posts! #ACLF #GSDMD #Alcohol
📖 Read it here: https://t.co/CJi4wk7wu6
@Gut_BMJ @BMJ_Open @FrontGastro_BMJ
A new Science #Immunology study describes how NEK7 phosphorylation downstream of potassium efflux and #GSDMD pore formation enhances NLRP3 #inflammasome activation in mouse macrophages. https://t.co/PYe2OJObx7
#NoTimeToDie! @rathinamVA, Weight &co show @CellCellPress that pyroptotic cells release extracellular vesicles which transplant gasdermin D #GSDMD pores to neighboring cells propagating cell death! https://t.co/elP492mu5w Free link to the paper 👉 https://t.co/1ecKb4p7cq
This prompted Mercedes Monteleone from @inflammasomelab to ask whether other effectors of #LyticCellDeath trigger filopodial marks on soon-to-be corpses. #GSDMD, other #gasdermins (#GSDMA, #GSDME) & #MLKL also induce cell assembly of filopodia before cell lysis 😯 (6/13)
Incredibly, minutes before pyroptotic #CellExplosion, cells assemble Myo10-capped #filopodia, which crown the resultant cell corpse. #inflammasome #GSDMD signalling was required for both filopodial assembly & cell death. Might Ca2+ influx via GSDMD pores be involved? 🤔(4/13)
@inflammasomelab star @CarolineLHolley used a suite of #HighRes #imaging methods to answer these questions, staining the plasma membrane (green) & using an #actin dye that enters via #GSDMD pores during #pyroptosis (purple), to resolve #ExplodingCells (3/13). Watch 👇:
Check out Lisa‘s take on her recent paper on the mechanism (and potential therapeutic targeting) of #GSDMD pore formation using #nanobodies.
🎬 Episode 11 of #SpotOnScience is out!
In this episode, Lisa Schiffelers from the group of @FISchmidtLab shares insights into her work on unraveling gasdermin D (GSDMD) pore formation using nanobodies. 👩🔬
Check out the episode: https://t.co/AU2xJV7IFm
Epic effort from Flo & first author Lisa Schiffelers of @FISchmidtLab .
Antagonistic camelid #nanobodies are small enough to traverse early #GSDMD pores to inhibit further #pore #formation.
Monomers target the membrane, suggesting #monomer to #oligomer transition on #membrane.
Ever wondered why there is so little #microscopy of #GSDMD pores? Check out how Lisa Schiffelers used #Nanobodies to stabilize monomeric GSDMD in the plasma membrane, to dissect the steps of pore formation, and to develop some new ideas for therapy.
https://t.co/DmCnqN8Chl
In parellel work, @anja_kopp @Geyer_lab solved the structure of two of our #nanobodies bound to #GSDMD. https://t.co/Mz4JKPCRlc.
The Feng Shao lab also used #AAV to express one of our #GSDMD #nanobodies to prevent loss of the #BBB during sepsis.
https://t.co/bpBxpMhBwA
We think the antagonistic GSDMD #nanobodies enter cells when the first #GSDMD pores form. They prevent any further pore formation and thus -in combination with cellular repair mechanism- prevent cell death by pyroptosis. We are looking forward to test this concept in vivo ...
As cells no longer die by #pyroptosis, stabilized, endogenous #GSDMD in the plasma membrane can even stained with antibodies for cleaved GSDMD.
Surprisingly, expression of antagonistic #GSDMD #nanobodies stabilized monomeric GSDMD NTD-mNeonGreen in the plasma membrane.
We had previously tried to use a cool tool from @inflammgenetics to visualize #GSDMD pores in living cells (mNeonGreen remains with the #GSDMD NT), but mostly found GSDMD in intracellular structures ...
We raised #alpaca #nanobodies against #GSDMD and found that two cytosolically expressed nanobodies completely shut down pore formation, #pyroptosis, and cytokine release after #inflammasome activation ....
Ever wondered why there is so little #microscopy of #GSDMD pores? Check out how Lisa Schiffelers used #Nanobodies to stabilize monomeric GSDMD in the plasma membrane, to dissect the steps of pore formation, and to develop some new ideas for therapy.
https://t.co/DmCnqN8Chl
#LiveForever! Chi, Wang &co show @Nature that gasdermin D #GSDMD has a “non-canonical metabolite-secreting function” that allows the release of a pro-healing oxylipin that favors FGF-FGFR signaling driving muscle regeneration & rejuvenating aged muscles!! https://t.co/UR0chKwByN
#WeekendRead!#NoTimeToDie! Lieberman, @WuLabHarvard with @JudithAgudo1 &co identify @CellCellPress a compound that leads to #GSDMD pore formation independently of cleavage & induces immunogenic death of #tumors potentiating checkpoint blockade therapies! https://t.co/9mZr2OD6an
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