Derek Abbott

Cecil and Ida Green Chair of Immunology and Genomic Medicine. National Jewish Health. Physician Scientist target hunting in inflammation. Views are my own.

[Derek Abbott @inflammgenetics]

@LangmanVince Northeast Ohio has very high taxes. He'll pay 2.5% to Cleveland, 1.5% to Westlake (Rita tax, where he lives), 2.75% to Ohio and then $25K in property taxes. California costs more, but there's a big difference in Ohio taxes in the Cleveland area versus, say, Dayton. He's paying.

[Dr. Catharine Young @DrCatharineY]

In case you still think there is any normalcy in how scientists are being treated at NIH.

Photo credit: 27UNIHTED

[Rep. Jake Auchincloss 🟧 @RepAuchincloss]

Asked mid-season about the Yankees, former Red Sox General Manager Theo Epstein once said that he had looked at their roster at the start of the season, realized that they'd win 100 games, and now ignored their weekly standings in order to focus on his own roster's ability to compete.

I raised this anecdote at a recent roundtable of experts discussing China's rise in biotechnology. China is uplifting scientists, investing hundreds of billions in R&D, and accelerating clinical trials. It's going to win 100 games. The center of biomedical gravity is moving to China from America, just like it moved from Europe to America at the close of last century.

Unless America decides to win 110 games.

https://t.co/8H4eCKOzb8

[Derek Abbott @inflammgenetics]

Drug targeting human MLKL might focus on preventing the release of the 4-Helix bundle rather than preventing MLKL phosphorylation. 4/4

[Derek Abbott @inflammgenetics]

CWRU MSTPstudent Michelle Pan's dissertation is now available online. In this work, Michelle challenged the idea that, in human necroptosis, RIPK3 phosphorylation of MLKL is the main pore-initiating event. 1/3

https://t.co/91toNwRENq

[Derek Abbott @inflammgenetics]

MLKL prevents further kinase activity of RIPK3 beyond the initial auto-phosphorylation at sites 224 and 227. In humans, Michelle's work shows that the key initiating event in MLKL activation is not phosphorylation but rather a flipping of the 4-helix bundle of MLKL. 3/4

[Derek Abbott @inflammgenetics]

@MikeReiss Great stuff as usual, Mike! Any word on Jedrick Wills? His knee injury might have been mismanaged by the Browns. They tried to convert him from right tackle to left tackle, where he was serviceable, if not more than average. Thoughts on him being a Morgan Moses backup?

[Derek Abbott @inflammgenetics]

Excited for ⁦@cwrumstp⁩ and new Abbott lab alum, Michelle Pan, to defend her dissertation today! Congratulations to Dr Pan. Look out for her paper coming out in a couple of weeks!

[Derek Abbott @inflammgenetics]

This weekend, my wife and I were very excited to attend our first Beaux Arts Ball at National Jewish Health. Its very inspiring to work at an institution dedicated to finding treatments and cures for immunologic diseases and to work with such a dedicated team. @KathrynTeng

[Derek Abbott @inflammgenetics]

@MaroonBlackPuck Kathryn and I are following from Denver. LETS ROLL US!!!!

[Derek Abbott @inflammgenetics]

@SavageSports_ He used to be very good, but the Browns benched him late in the season. Given the state of their OLine, he might be done.

[Derek Abbott @inflammgenetics]

Pleased to share a new review article focusing on Gasdermin D's role in Pathology spearheaded by Bowen Zhou, a former @cwrumstp student and current Pathology fellow @UHhospitals

https://t.co/GmjEGXwUxk

[Derek Abbott @inflammgenetics]

@BishopBarron We pay >$95K a year for my son to attend Dartmouth. Let's see her start with Point #1 first.

[Derek Abbott @inflammgenetics]

@JohnStreicher1 @drugmonkeyblog I think I may put PMCIDs in the body of the text describing contributions to science? Without any references, you could just say anything (ie after I completed my career as a top gun fighter pilot and piloted the space shuttle into orbit, I turned my attention to science).

[Derek Abbott @inflammgenetics]

Is the consensus on the new online NIH Biosketch that we cannot list manuscripts in the "Contributions to Science" section? @drugmonkeyblog

[Vijay Rathinam @RathinamVA]

Shiga toxin-induced cell death—the underlying cause of a potentially fatal renal disease in children—occurs via pyroptosis, not apoptosis as previously thought, and is driven by an intriguing NLRP1->Caspase-3-> gasdermin E pathway. Congrats to Priya's lab! https://t.co/HkZqUM2baE

[Derek Abbott @inflammgenetics]

This isn’t the case at National Jewish Health. We are actively hiring to expand our tenure track faculty in Immunology and genomic medicine. https://t.co/H6ltXfqkV2

[Nature Reviews Drug Discovery @NatRevDrugDisc]

FDA approves 100th small-molecule kinase inhibitor https://t.co/VjvGosLZ8f

From the landmark approval of the anticancer drug imatinib almost a quarter century ago, our latest news feature analyses trends in the field of kinase inhibitors, now one of the major drug classes

[Derek Abbott @inflammgenetics]

@BuckSt87 Meanwhile, Vanderbilt beats them all at 21st...