Top Tweets for #IberDd
@SagarLonialMD @US_FDA @Amyloid_Planet @DrOlaLandgren 57) Our take: #IberDd is positioned as a new standard-of-care option for #RRMM that can be used as early as 1st relapse, across diverse clinical settings including community practice. The maturing #PFS data will be the next thing to watch closely. #IMS2026 #RRMM
@SagarLonialMD @US_FDA @Amyloid_Planet @DrOlaLandgren 56) @SagarLonialMD: These data suggest that #IberDd has a higher chance of inducing MRD negative CR but is subject to cross trial comparisons and other differences in patient populations and perhaps a time bias.
@SagarLonialMD @US_FDA @Amyloid_Planet 54) A companion matching-adjusted indirect comparison of #IberDd vs Dd- and #IMiD-containing regimens was also presented here at #IMS2026 by @DrOlaLandgren:
@SagarLonialMD @US_FDA 44) Deaths were reported in 11.1% (#IberDd) vs 15.5% (#DVd), primarily from progressive disease. Grade 5 TEAEs: 5.4% vs 2.5%, of which 1.5% vs 1.0% were considered treatment-related. #EXCALIBER_RRMM
@SagarLonialMD @US_FDA 43) Also worth noting: any-grade #hypogammaglobulinemia 16.7% (#IberDd) vs 10.3% (#DVd), with #IGRT given to 27.9% vs 13.7%. #VTE occurred in 5.9% vs 3.9%. There were no grade 3/4 events with IberDd, with mandatory thromboprophylaxis in that arm. #RRMM
@SagarLonialMD @US_FDA 42) Infections: any infection 78.9% (#IberDd) vs 69.6% (#DVd); grade 3 35.8% vs 21.1%, grade 4 3.4% vs 0.5%. Pneumonia 23.5% vs 11.3%. Only 1.5% (n=3) discontinued iber due to infection; fatal infections were low & similar (2.0% vs 1.5%). #EXCALIBER_RRMM
@SagarLonialMD @US_FDA 41) Contrast the two arms’ toxicity signatures: thrombocytopenia was LOWER with #IberDd (36.8% any grade; 12.7% grade 3/4) than #DVd (62.7%; 44.1%). Rates of grade 3/4 diarrhea, fatigue, & rash were low & similar between arms. #RRMM
@SagarLonialMD @US_FDA 40) How was neutropenia managed? 82.4% of #IberDd pts received #G_CSF. Iber dose modifications for neutropenia: 51.5% dose interruption, 13.2% dose reduction, & only 1.0% (n=2) discontinuation. Grade 3/4 rates fell sharply after cycles 1–2. #IMS2026
@SagarLonialMD @US_FDA 39) The dominant toxicity is on-target & reversible: #neutropenia in 89.2% any grade / 84.3% grade 3/4 with #IberDd vs 24.0%/11.3% with #DVd. Febrile neutropenia, importantly, was uncommon at 5.4%. #RRMM
@SagarLonialMD @US_FDA 38) Safety: the profile was generally predictable & manageable, consistent with the known effects of #CELMoDs & Dd. Any-grade #TEAEs occurred in essentially all pts in both arms; grade 3/4 in 91.7% (#IberDd) vs 70.1% (#DVd). #EXCALIBER_RRMM
@SagarLonialMD @US_FDA 37) For cross-trial context (with all the usual caveats about design, MRD methodology, population, & follow-up differing) the 41% MRD-negative CR rate w/#IberDd sits at the upper end of reported #RRMM triplet data (DPd 9%, DKd 14%, IsaKd 20%, BPd 24%, BVd 25%). #RRMM
@SagarLonialMD @US_FDA 36) Depth of response overall: #ORR 88.9% with #IberDd vs 76.1% with #DVd. ≥ #VGPR 74.4% vs 61.5%. And ≥ CR 45.9% vs 24.9%; IberDd nearly DOUBLED the ≥ CR rate. (Not adjusted for multiplicity; not formally tested.) #EXCALIBER_RRMM
@SagarLonialMD @US_FDA 32) THE HEADLINE: MRD-negative #CR at any time was 41.1% with #IberDd vs 20.7% with #DVd. This is a proportion difference of 20.1% (95% CI 11.5–28.6; P<0.0001), odds ratio 2.75 (95% CI 1.77–4.30). The dual primary MRD endpoint was met. #EXCALIBER_RRMM #IMS2026
@SagarLonialMD @US_FDA 31) Disposition at median follow-up 15.7 months: 62.3% of #IberDd pts remained on treatment vs 46.0% on #DVd. Discontinuation for progressive disease: 15.9% vs 35.2%. Iber relative dose intensity was high at 90.5%; discontinuations for AEs were infrequent. #IMS2026
@SagarLonialMD @US_FDA 29) Who enrolled? #IberDd n=207, #DVd n=213. Median age 68 (range 37–85); 18.8% were ≥ 75 years. High-risk cytogenetics in 23.2%; expanded high-risk (adding amp1q21) in ~50%. Soft-tissue plasmacytomas in ~11%. Arms were well balanced. #EXCALIBER_RRMM
Last Seen Hashtags on Sotwe
mgai(*)*************filter:videos
Seen from United Kingdom
incesto #mae
Seen from Brazil
incest movie
Seen from Turkey
prank coli
Seen from Malaysia
stw
Seen from Singapore
aigirl
Seen from United States
publiccum
Seen from Turkey
weddingsex
Seen from Pakistan
Teeen
Seen from Sweden
sex
Seen from United States
Trends for you
Most Popular Users
Elon Musk 
@elonmusk
241.7M followers
Barack Obama
@barackobama
119M followers
Cristiano Ronaldo
@cristiano
114.4M followers
Donald J. Trump
@realdonaldtrump
111.9M followers
Narendra Modi
@narendramodi
107.2M followers
Rihanna
@rihanna
98.7M followers
NASA
@nasa
92.4M followers
Justin Bieber
@justinbieber
91.8M followers
KATY PERRY
@katyperry
90M followers
Taylor Swift
@taylorswift13
83.9M followers
Lady Gaga
@ladygaga
75.4M followers
Virat Kohli
@imvkohli
73.4M followers
Kim Kardashian
@kimkardashian
70.9M followers
YouTube
@youtube
68.8M followers
Neymar Jr
@neymarjr
66.4M followers
Bill Gates
@billgates
65.2M followers
Selena Gomez
@selenagomez
63.1M followers
The Ellen Show
@theellenshow
62.3M followers
CNN
@cnn
61.8M followers
X
@x
60.7M followers