Top Tweets for #KnowTheScience
💉 IV FFP Builds Clots ✅ | 🧠 Perineural FFP Just Blocks ❌
#RegionalAnaesthesia #FreshFrozenPlasma #PatientSafety #Coagulopathy #AnaesthesiaRisk #IVvsPerineuralFFP #FeasibilityNotEfficacy #AnaesthesiaDebate #KnowTheScience #TipOfTheDay #MyRATips
Tip of the Day:
A.💉 INTRAVENOUS FFP (Standard Use)
🧪 Content → plasma with all soluble clotting factors (I–XIII), fibrinogen, albumin, globulins, anticoagulants (protein C/S, antithrombin), and citrate as preservative
⚙️ How it helps → replenishes clotting factors → restores the extrinsic & intrinsic pathways → generates thrombin → converts fibrinogen to fibrin → stable clot formation
🩸 Indications → INR > 2 with urgent surgery, active bleeding, liver disease, DIC, massive transfusion, warfarin reversal (if PCC unavailable)
⏱️ Onset → minutes after infusion (10–15 mL/kg dose dependent)
📚 Evidence → strong, guideline-supported
⚠️ Risks → TRALI, TACO, allergy, infection (rare)
✅ Regulatory Status → licensed, proven, predictable
B. 🧠 PERINEURAL FFP (Experimental Use)
🎯 Claimed action → “acts like fibrin glue” to seal perineural bleeds
🧪 Reality → ❌ no thrombin trigger + citrate chelates Ca²⁺ → no local fibrin clot
💦 True effect → simple volume tamponade (mechanical pressure), not hemostasis
1. Pharmacological Concerns
⚡ Local anaesthetic interactions →
📍Dilution of LA → weaker block
📍Protein binding → slower onset, prolonged duration
📍Higher viscosity → restricted spread, unpredictable efficacy
2. Safety Concerns
🧩 Neurotoxicity potential → protein-rich fluid + citrate may irritate nerves, disrupt ion balance, or cause ischemia from pressure
🔥 Sterile inflammation → non-physiological proteins around nerves can provoke perineuritis
🦠 Infection risk → plasma is a nutrient-rich medium, raising concern for bacterial growth if contamination occurs
🛑 Compression injury → injected volume may elevate fascial compartment pressures, risking ischemic nerve damage
3. Ethical Concerns
⚖️ Off-label biologic use → perineural deposition of a blood product is not approved
📝 Governance gap → case consent ≠ ethical clearance; requires IRB approval and protocol registration
🚨 Publication risk → reporting feasibility without mechanistic proof may mislead clinicians into unsafe replication
C. 🧠 Why Perineural FFP Adds NO ADVANTAGE?
🚑Systemic correction is already mandatory → Once IV FFP is transfused, clotting factors circulate to all bleeding sites (including perineural tissue).
🧪Local FFP cannot polymerise → Without thrombin trigger + citrate chelation, perineural FFP cannot form a fibrin plug. Any effect is just mechanical tamponade.
⚠️Risk > benefit →
Additional injection volume → nerve compression
Plasma proteins → sterile inflammation, infection risk
No evidence that outcomes improve compared to IV correction alone
⚖️Ethical gap → IV use = standard of care; perineural use = off-label, unproven, potentially misleading if published as efficacy.
D.👉 BOTTOMLINE:
✅ IV FFP → proven systemic therapy, predictable, guideline-supported.
❌ Perineural FFP → mechanistically unsound, biologically risky, ethically problematic, and should remain strictly investigational.
👉When IV FFP already does the job, perineural FFP adds no cure - only confusion and risk.
GWAS can reveal association, not causation. Just because traits share DNA links doesn’t mean one causes the other. #KnowTheScience #GeneticTruth #CriticalThinking /22
It’s easy to get confused by health information these days with so many ads, social media posts, and “quick fixes” out there. That’s why it’s important to understand the science behind health. 🧠🔍
The #KnowTheScience toolkit from @NIH_NCCIH gives you simple, trustworthy tools to help you make smart choices about your health. Learn how to read health news, avoid harmful drug and supplement mixes, and more through videos, quizzes, and easy guides. 💊📘
Learn more: https://t.co/px45uiZUEM
#Health #Wellness #MedEd #PublicHealth
NCCIH’s #KnowTheScience toolkit aims to help consumers better understand scientific topics related to health research.
Check it out to learn how to make sense of scientific journal articles, avoid drug-supplement interactions, and much more! https://t.co/GGnkdSVmh0
Looking for reliable health resources online? Check out our #KnowTheScience toolkit. We have a new set of tools to help you find out whether websites, social media sites, and apps are trustworthy and to help you distinguish news from advertising. https://t.co/aXMrgS5PUo
Did you know that some dietary supplements can interact in undesirable ways with medicines? Get the details from this @NIH_NCCIH #KnowTheScience tool: https://t.co/sUKOyRSXtu
Our #KnowTheScience toolkit can help you better understand the science of health so you can be discerning about what you hear and read. The kit includes interactive modules, quizzes, and videos to help you get to know the science. Check it out! https://t.co/Gf7CRW6nL3
The use of plants as medicines has a long history in the treatment of disease and in improving our health. For information about the safety and effectiveness of natural products, check out our Herbs at a Glance series and our #KnowTheScience tools.
https://t.co/r2Xun3PcDQ
You can sharpen your health literacy skills with the @NIH_NCCIH #KnowTheScience toolkit. Learn how to avoid drug-supplement interactions, evaluate health news stories, find trustworthy health information online, and much more! #HealthLiteracyMonth https://t.co/OjeN1pAakw
Our #KnowTheScience tools can help you better understand complex scientific topics so you can be more informed when making decisions about your health. Check it out: https://t.co/lCGr2Ql9OO
The word "omics" refers to a field of study in biological sciences that ends with -omics, such as genomics, proteomics, or metabolomics.
Learn more here: https://t.co/LU3Tjgsm4m
#Genomics #Proteomics #Metabolomics #Biotechnology #KnowTheScience #ISAAA
With the new year approaching and new health goals in the works, always do your research before starting a new dietary supplement or health regimen. View our resources on making informed decisions about your health here: https://t.co/lCGr2QkBZg
#HealthLiteracy #KnowTheScience
If your reading intervention is computer led you are in fact NOT providing evidence based intervention.
#knowthescience
@missypurcell1 As Joe Torgesen said, computerized instruction can supplement teacher-led instruction, but never replace it! https://t.co/yAVl0FkNFP
Do you need help deciding whether you can trust a news report about complementary and integrative health? This #KnowTheScience tool can help you figure out whether the news report is giving you the full story. https://t.co/YHF8uIkhlr
Our Center provides tools that may help you better understand complex scientific topics that relate to health research. Our #KnowTheScience resource may help you make well-informed decisions about your health. https://t.co/lCGr2Ql9OO
Our Center provides tools that may help you better understand complex scientific topics that relate to health research. Our #KnowTheScience resource may help you make well-informed decisions about your health. https://t.co/lCGr2Ql9OO
11. Let's not ignore what we learned in school, because it can very well be the key to navigating this pandemic safely. #KS3Science #COVID19 #KnowTheScience
It’s important to know the science of health because there is a lot of misinformation circulating. Our #KnowTheScience tools can help people better understand complex scientific topics and make well-informed decisions about health. https://t.co/lCGr2Ql9OO
It’s important to know the science of health because there is a lot of misinformation circulating. Our #KnowTheScience tools can help people better understand complex scientific topics and make well-informed decisions about health. https://t.co/lCGr2QkBZg
There is a lot of health misinformation out there. Our #KnowTheScience tools can help you make more informed decisions about your health.
https://t.co/lCGr2Ql9OO
We agree! “Natural” doesn’t necessarily mean “safer” or “better” & knowing why is critical to navigating decisions about your health. Check out our #KnowTheScience toolkit for more information. https://t.co/FamU0qA63d
The occasional reminder that...
Not everything that's Natural is good for you. And not everything that's good for you is Natural.
Do you have questions about research articles after running a search in #PubMed? Understanding the basics of scientific studies may help you make better health decisions. This #KnowTheScience module can help. https://t.co/H4fZxqFQtz
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