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Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction HOLY MACARONI!! 🚨FURTHER CONFIRMATION: SARS-CoV-2 doesn’t leave quietly, it permanently reprograms your genome toward Neurodegeneration!!! ➡️This new USA study performed whole-genome methylation sequencing (WGMS) on peripheral blood from 101 SARS-CoV-2-positive patients (asymptomatic to severe) versus 105 uninfected controls to map COVID-19-induced epigenetic changes and their links to neurological outcomes. ➡️Highlights: • Widespread genome-wide DNA hypomethylation in infected individuals, markedly intensified in severe cases, • Severity-stratified differentially methylated genes (DMGs): 19 in mild, 19 in moderate, and 35 in severe symptoms, • DMGs overlapped both canonical immune-response pathways and genes tied to neurodegenerative diseases, • Pathway enrichment (GSEA, g:Profiler, PANTHER, KEGG) strongly associated DMGs with Alzheimer’s disease, Parkinson’s disease, and neuropsychiatric conditions, • Whole-genome methylation sequencing(WGMS) provided the first comprehensive severity-stratified map of these methylation shifts, implicating epigenetic reprogramming in acute immune dysregulation and potential long-term neurological sequelae, #Leonardi_effect • “It is important to note that our study is not causative by nature and only indicates associations," • Study also supports the view that COVID-19 is a spectrum of distinct syndromes rather than a single disease entity. ‼️So, COVID-19 does not merely infect, it permanently rewires the human epigenome in patterns identical to Alzheimer’s and Parkinson’s, guaranteeing a future epidemic of neurological degeneration, 😧have a nice Saturday! https://t.co/pXynKMAif3