Top Tweets for #MDedgeTweets
Novel formulation ("co-crystal") of opioid tramadol plus NSAID celecoxib for oral, acute #pain tx gets 13-13 split vote for/against approval from #FDA advisory committee. https://t.co/WFsoTfLiCs https://t.co/QpoC4WwiUB #MDedgeTweets
#FDA advisory committee votes 27-0 against approval of #oxycodegol, new opioid molecule designed to give pain relief with slower brain entry and less of a high, largely bc of inadequate safety and efficacy data. #MDedgeTweets https://t.co/DGp7HjmyYu
This new finding in #chroniccoronarysyndrome and post-MI pts defines a novel, high-risk group: pts who develop angina; & they need immediate cath. This prognostic red flag raised by angina wasn't seen in CCS pts without a prior MI. #ESCcongress #MDedgeTweets
Registry data on 33,000 chronic coronary syndrome pts show post MI pts who get #angina had a 50% relative rise in CV death or MI compared w similar pts w/o angina during 5-yr follow-up. https://t.co/wo6mzSR5Yk https://t.co/Np0TVmjYuw #ESCcongress #MDedgeTweets
ORION-11: Phase 3 trial of small interfering RNA that targets the PCSK9 gene produced 50% cut in LDL-cholesterol using 4 injections delivered over a 17-month period with very uniform pt responses and safety similar to placebo. #ESCcongress #MDedgeTweets
The report by Glasgow physician John McMurray was met by several loud rounds of applause from a packed ESC audience, and several experts praised the findings for ushering in a new drug class for treating hrt failure w reduced LVEF. #ESCcongress #MDedgeTweets
Lack of a stat sig primary endpoint in PARAGON-HF led to controversy about implications of the results for routine practice. No proven effective tx currently exists for HF with preserved EF. #ESCcongress https://t.co/hoMjEEr6eQ #MDedgeTweets
Ixekizumab outperformed adalimumab for #psoriaticarthritis in first head-to-head trial in PsA with agents from two different biological classes. https://t.co/jXLCwDefSA #EULAR2019 #MDedgeTweets
But during 2000-2009, CVD events rates were roughly similar among RA patients and the general population in study of 1,800 Mayo Clinic, Minn. pts. #EULAR2019 #MDedgeTweets
Researcher who reported this said it's not yet clear why a lower number of joints assessed led to efficacy overestimates at the phase 2 stage, but he recommended that future phase 2&3 RA trials rely on assessing 66 joints/patient. #EULAR2019 #MDedgeTweets
New #cardiogenicshock classification scheme issued by a #SCAI panel gained endorsement from the Amer Coll of Cardiology, the Amer Heart Assoc., & other groups. https://t.co/3KTCsp7AaM #SCAI2019 #MDedgeTweets
#Givosiran treatment of 48 pts in ENVISION linked with 5 cases of chronic kidney disease (two serious) compared with none among 46 placebo control pts, and three total cases of serious, rx-related adverse events vs none with placebo. #ILC2019 #MDedgeTweets
Finding suggests that African residents may harbor several as-yet poorly studied #HCV subtypes that are not fully responsive to current HCV antivirals and that new agents may be needed for global HCV control. #ILC2019 #MDedgeTweets
Don't forget to set a reminder to join the conversation next Wednesday at 6:00 PM. Meet here to discuss the #ApplyHeartStudy's findings, implications for the field of EP, and more. #HRSchat #EPeeps #CardioTwitter #MedTwitter #HRSDigitalHealth #DigitalHealth #Wearables #HealthTech
First phase 3 trial to show tx benefit in NASH pts. Study PI Zobair Younossi called results a "watershed moment" for NASH tx . Obeticholic acid already FDA approved (Ocaliva) to tx primary biliary cholangitis, much less common than NASH. #ILC2019 #MDedgeTweets
#TexasTech first to stop using race in #medschool admissions under #DeVos plan https://t.co/HPBPSo7JLk #MDedgetweets
#FDA #breastimplant advisory panel chair Dr. Frank R. Lewis, Jr.: Existing informed consent materials for implant pts were "not constructed to inform patients; they were constructed to provide legal protection." #MDedgeTweets.
INFINITY findings add to accumulating evidence of neurological benefits from more intensive bp control, and further document the safety of current U.S. #hypertension targets in the #elderly. #ACC19 #MDedgeTweets
First-ever guidelines for cardiovascular disease primary prevention promotes assessing social determinants of health, says don't use aspirin in people older than 70, & suggests infrequent aspirin use in younger adults. https://t.co/AY8xcW5Vit #ACC19 #MDEdgeTweets
mSToPS trial of patch-based A Fib screening picked up 3x more AF cases than usual care https://t.co/aKNKLGuYO4. New data show AF cases diagnosed by patch had 65% less ED visits & 80% less hospitalizations than AF patients diagnosed w routine care. #ACC2019 #MDedgeTweets
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