Top Tweets for #MMUpdate
@SoMeCME @DrOlaLandgren @JoshuaRichterMD PERSEUS AEs
Key takeaway: Observed D-VRd safety profile consistent w/ expected; less G3/4 fatigue & rash
G3/4 AE, %:
Neutropenia: 62 vs 51
Infections: 35 vs 27
Thrombocytopenia: 29 vs 17
Fatigue: 2.8 vs 5.2
Rash: 2.6 vs 4.9
NEJM: https://t.co/kI9FdEubma
#MMUpdate #MMSM
@SoMeCME @DrOlaLandgren @AjayNookaMD D-VRd or Isa-VRd for TE-NDMM
Key takeaway: D-VRd regimen easier for patients who are frail or w/ comorbidities
D-VRd vs Isa-VRd:
↓ AE rate vs VRd
Longer follow-up
↑ PFS vs NR
#MMUpdate #MMSM
6/ We hope you enjoyed this #multiplemyeloma education❗
Complete the posttest & evaluation here 👉 https://t.co/jdPsazfQxn
& claim your 🆓 CME!
#MMUpdate #MMSM
1/🎥What do the PERSEUS results say about the efficacy & safety of D-VRd❓Is VRd still a relevant treatment for TE patients w/ NDMM❓How comparable are the quadruplet regimens❓
@DROlaLandgren will tell you all about it in the video below❗
#MMUpdate #MMSM
https://t.co/tnurDznzVw
Don't miss today's #MMUpdate!
💬 PERSEUS Trial Insights from ASH
👥 @DrOlaLandgren, @AjayNookaMD, & @JoshuaRichterMD
🕓 12:00 PM EST
📆 https://t.co/efyQZ669y9
#MedEd #FOAMed #MMSM #MultipleMyeloma
@SoMeCME @DrOlaLandgren @JoshuaRichterMD AE Management in CARTITUDE Trials
Reduce MNT risk:
Strategies:
Prevent: personalize bridging therapy, discuss risk reduction w/ patients
Monitor: assess handwriting
Manage: early & aggressive supportive care, pharmacologic for ICANS
https://t.co/jkBULXmQpq
#MMUpdate
@SoMeCME @szusmani @JoshuaRichterMD CARTITUDE-02 AEs of Special Interest
CRS & neurotox low grade w/ cilta-cel #MMUpdate
AESI (% any grade/grade 3/4; cohort A vs B
CRS: 95/19 vs 84/5
Neurotox: 30/5 vs 32/5
ICANS: 15/0 vs 5/0
MNT: 0/0 vs 5/5
Resolution:
All CRS & ICANS
66% of neurotox
https://t.co/K6y5ys2ouv
@SoMeCME @szusmani @JoshuaRichterMD BMCA
Multiple anti-BMCA agents approved
BCMA:
TNFR superfamily member
Expressed on normal & clonal plasma cells
Role in B cell maturation & plasma cell survival
Approved agents:
CAR T cell therapies
BCMAxCD3 bispecific mAbs
Review: https://t.co/DaiW827KV1
#MMUpdate
@SoMeCME @szusmani @AjayNookaMD CARTITUDE-4: Cilta-cel PFS by MRD and Best Response
PFS: HR 0.36 (95% CI 0.15, 0.88), P=.0196; at 12 months: 89% vs 71%
ORR: 99%; ≥CR: 86%
MRD negativity: 72%
Poster: https://t.co/5p9L8hKVY2
#MMUpdate
#mmsm
@SoMeCME @szusmani @AjayNookaMD CARTITUDE-4: Cilta-cel vs SOC
↑ outcomes w/ cilta-cel vs SOC for NDMM P3 CARTITUDE-4 (N=419) #MMUpdate
Median follow-up: 15.9 months
PFS: HR 0.26; at 12 months: 89% vs 71%
ORR: 85% vs 67%
≥CR: 73% vs 22%
MRD negativity: 88% vs 33%
NEJM: https://t.co/eSiedoVbmI
5/ We hope you enjoyed this #multiplemyeloma education!
Complete the posttest & evaluation here 👉 https://t.co/AmEtyC1DKw
& claim your 🆓 CME!
🗓️ Join us for #MMUpdate #2 on Wednesday, December 20, 2023 @ 12:00 PM EST w/ @DrOlaLandgren, @AjayNookaMD, & @JoshuaRichterMD #MMSM
The 1st #MMUpdate is happening today!
💬 CARTITUDE-2 Trial Updated Results
👥 @szusmani, @AjayNookaMD, & @JoshuaRichterMD
🕓 12:00 PM EST
📆 https://t.co/hBM7kCLCEt
🆕 #MMUpdate series
1️⃣ https://t.co/losDFkWQmQ
💬 CARTITUDE-2 Trial Updated Results
👥 @szusmani, @JoshuaRichterMD, & @AjayNookaMD
2️⃣ https://t.co/efyQZ66HnH
💬 PERSEUS Trial Insights from ASH
👥 @DrOlaLandgren, @JoshuaRichterMD, & @AjayNookaMD
📢 NEW KEYWORD FILTERS IN WEBSITE PROFILER 📢
In Website Profiler, you can now filter out phrases that contain specific keywords. This new feature will save you tons of time when excluding brand keywords from your competitor keyword research.🥳
https://t.co/YfCzsjpg6y
#MMupdate
Marketing Miner’s Reports section has a new look! 🥳
Analyzing data in bulk has never been easier thanks to our latest update!🙌 Check out the new look and let us know what you think: https://t.co/wzsTfxNtoY
#SEOtool #MMupdate #databulkanalysis #datamining #seoaudit #keywords
🚨#MadMeerkat 🚨#mmupdate
Bit more in depth analysis here. I show the move over 7 days.
198 less on market (15%)
73 only below 600c (v 184 7d ago!)
6 bargains!! (<10% <$1k)
If you want an ID holla!
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