Top Tweets for #ModelAngelo
There we goπ€·. We have #alphafold3, @alexjamesnoble's VirtualIce, a plethora of (nearly) automated 3D reconstruction tools, #ModelAngelo... and AIs that can generate hypotheses, test them and write papers. #cryoEM can go home I guess.
In two new papers, researchers present AI agents that can do the entire job of a scientist β from hypothesis formulation, to literature research, data collection and analysis, all the way to writing a paper.
https://t.co/pPG8Rt8T0H
Big congratulations to Kenneth Carr and Dane Evan Zambrano, who co-led this study! π A special thank you to the developers of #ModelAngelo βthis incredible tool was crucial to our success. Our designed proteins thank you! π
Thanks to #CryoEM, #ModelAngelo', #BLAST, and #AlphaFold 3 predictions, we identified and modified our purification protocol to remove dihydrolipoamide succinyltransferase (hashtag#DLST) from our preps.
Excited to share our latest pre-print outlining a successful use case of #ModelAngelo and protein BLAST in helping us solve a tricky protein purification challenge in computational #ProteinDesign!
@UWproteindesign @UWBiochemistry @cryoEM_Papers
https://t.co/tAbwjjg2jf
@jankosinski Have you tried #ModelAngelo (https://t.co/ULrw8zcIKJ) from @SjorsScheres & co-workers? I have been really impressed by the accuracy of the GNN building in #cryoEM volumes with and without sequence input.
The development of #ModelAngelo represents a significant leap forward for #cryoEM! Accelerating the identification and modeling of proteins not only enhances our understanding of biological mechanisms but could also lead to novel therapeutic targets. For those diving deeper into biomedical inquiries, check out https://t.co/4Y9Imt8uIJ, a platform leveraging AI to deliver in-depth biomedical reviews tailored to your research needs. #LMBResearch #Medicine #OpenAI Sciqst powered by OpenAI.
@SjorsScheres @Nature @jamaliki1998 @kimanius @alanbrownhms @RuiZhangWUSTL Congratulations @jamaliki1998 and team Sjors!π₯³ #ModelAngelo sets the foundation for the future of automated model building in #cryoEM.ππ
This Thanksgiving, my thanks are to the residues that went into the density like the good bois they are. #ModelAngelo
You resolve a large complex cryo-EM map, you reconstruct with #modelangelo, you real space refine in #phenix, you use @ktototak 's #checkmysequence and you get the message below. A happy Friday. #cryoem #kastritislab
@SjorsScheres @klausenhauser @ImagingArtifact Going for #ModelAngelo was my first optimistic idea. Twitter was the B plan. Even though, it seems we will need to go for C plan =more data=better resolution and ModelAngelo π
π¨Updated tool alertπ¨ We have updated #modelangelo to v1.0.1. See thread below about changes - updates include working beautifully for protein, DNA, and RNAπ. Ex: PDB 8G1I / EMDB 29671 that has protein, dsDNA, and RNA https://t.co/iuyZlc2GsE
Bringing home the #cryoEM workshop on day 4 is @alanbrownhms telling us about model building and leading us through tutorials with #coot, #modelangelo, and #phenix. A nice look 'under the hood' at how he has been able to build so many models into axonemal structures!
Iβm loving the name #ModelAngelo
@SjorsScheres @jamaliki1998 We recently discovered a novel virus by cryoEM. Although we figured out its relatives by manual inspection of the map, today we retrospectively analyzed it with #ModelAngelo and indeed this was as effective as next-gen sequencing in determining the closest relative
Ok, finally found some time to play with #ModelAngelo
@SjorsScheres Iβm assuming that for homooligomers I just repeat the seq in the fasta file? #cryoEM #GNN
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