Top Tweets for #MultisystemicSmoothMuscleDysfunctionSyndrome
#MultisystemicSmoothMuscleDysfunctionSyndrome #MSMDS
Myh11+ Smooth Muscle Cell Acta2 R179H transgenic🐭(?Age?)
⏬Cerebral artery curviness, inner diameter
⏬Cerebral arterial contractile proteins
⏫Cerebrovascular SMC proliferation in culture
⏬Spontaneous cerebral blood volume fluctuation (BOLD)
⏬Vasoresponses to both SNP & PE
⏫Anesthetized BP (likely as compensation)
⏬Cerebral blood flow & ⏫Survival upon unilateral common carotid occlusion
⏬White matter myelination
⏬Cortical neurons
⏫Neurobehavioral anomalies
@imai_takahiko @chungmdphd bioRxiv 2026
https://t.co/l5ZU7zDn1Y
🐭#SmoothMuscleCell heterozygous KnockIn of Acta2 R179C mutant, a pathogenic mutant of #MultisystemicSmoothMuscleDysfunctionSyndrome
~2/3 aortic SMCs KI
No #AorticDilation by 12-mo
BUT 👀the crazy SMC disarray!
Dr. Dianna Milewicz lab @JMCCardiology 2022
https://t.co/990S2Y7rxL
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