Top Tweets for #NatureCancerPicks
A trifecta of #celltherapy @NatureMedicine this week, including local delivery via CSF for CNS tumors and PD1 #CRISPR edited CAR-Ts by Mok, Mackall and Taylor
https://t.co/H4X3XXwRQk
https://t.co/oOVAQ79emz
https://t.co/PDk7Ev6tBe
#WeekendReads #NatureCancerPicks
Published in @JAMAOnc: radiolabeleld PARPi PET imaging using [18F]FTT in breast cancer patients across different subtypes to identify responders to this #cancer #therapy
https://t.co/K9aNqd2nGz
#WeekendReads #NatureCancerPicks
![NatureCancer's tweet photo. Published in @JAMAOnc: radiolabeleld PARPi PET imaging using [18F]FTT in breast cancer patients across different subtypes to identify responders to this #cancer #therapy
https://t.co/K9aNqd2nGz
#WeekendReads #NatureCancerPicks https://t.co/krizLhdYQM](https://pbs.twimg.com/media/EW9h20-XYAAvQwx.jpg)
More #WeekendReads #NatureCancerPicks
"Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I" very nice work from @KeisukeYamamo12 @AlecKimmelman @rushika_perera @nature with a News&Views from @Aiims1742
https://t.co/SL1eik8BJa
https://t.co/SnDycaBqpL
To make Fridays special @NatureCancer has prepared some #WeekendReads #NatureCancerPicks:
First off, a fabulous work @NatureGenet describes a framework to harmonize content, structure and literature across variant interpretation databases - don't miss!
https://t.co/nmv0CXlRuq
. #WeekendReads - The "Know Your Tumor" trial (>1000 patients) shows benefit (OS and PFS) of molecular guidance in matched therapy for #PancreaticCancer - impressive study by @MPishvaian and co @TheLancetOncol
#NatureCancerPicks
https://t.co/X9PWvQi24D
More #weekendreads: Eva Perez-Guijarro and Glenn Merlino report a new generation of mouse models representing the spectrum of human melanoma to understand clinical responses to #Immunotherapy @NatureMedicine
#NatureCancerPicks
https://t.co/LTv9li4XUG
MYSTIC trial: Durva+Tremelim (vs chemo) in metastatic NSCLC doesn't improve OS or PFS (pts with>25% PD-L1+ cells). Encouraging that >20 muts/Mb have improved OS in exploratory analysis. Fabulous study by @peters_solange &co #NatureCancerPicks #weekendreads https://t.co/hBuofsDvP9
๐กHas anyone NOT seen this cool paper @NatureBiotech yet? The imaging is BEAUTIFUL๐ Ultra-bright biocompatible near-IR-IIb rare-earth nanoparticles to track immune checkpoint inhibition in vivo #NatureCancerPicks @Stanford @hdai32982194
LINK: https://t.co/svOqZEe6Xj
Check out this tweetorial by @SerenaNikZainal on their recent @NatureMedicine publication using the mutational-signature-based algorithm HRDetect to predict triple negative breast cancers (TNBC) outcome
@Cambridge_Uni @lunduniversity #NatureCancerPicks
https://t.co/gNWhSGpjAu
Our paper on clinical value of whole genome sequencing (WGS) of triple negative breast cancers (TNBC) is out! @NatureMedicine
#SCANB @Cambridge_Uni @lunduniversity
Can our mutational-signature-based algorithm HRDetect predict outcome? Find out๐
https://t.co/Au2wGtut0g
1/
Excited to see our @getz_lab #PassengerHotspots paper chosen as one of the #NatureCancerPicks @NatureCancer ๐๐ผ. Also excited to see @JulianMHess watercolor-like #DataArt (Figure 5) as the featured pic! @gaddyg #SciArt
A Log-Normal-Poisson model developed by @getz_lab and Michael Lawrence @broadinstitute @MGHCancerCenter identifies inherently mutable genomic sites and discriminates passenger vs putative driver hotspots with fewer false-positives #NatureCancerPicks
A Log-Normal-Poisson model developed by @getz_lab and Michael Lawrence @broadinstitute @MGHCancerCenter identifies inherently mutable genomic sites and discriminates passenger vs putative driver hotspots with fewer false-positives #NatureCancerPicks
Another recent paper by @sidichen @YaleMed @YaleCancer
(RT @NatureBiotech )
In vivo CRISPR screening in CD8 T cells with AAVโSleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma
#NatureCancerPicks
https://t.co/IgaNSXlJHQ
A 3D-multicomponent screening system for ionizable lipid-like materials to improve RNA vaccines identifies formulations promoting RNA delivery + STING response, resulting in enhanced anti-tumor immunity @kochinstitute @NatureBiotech #NatureCancerPicks
https://t.co/0sOu9w7CNi
(!) Some very interesting papers recently on anti-tumor immunity
MAEGI: Multiplexed Activation of Endogenous Genes by CRISPRa to elicit anti-tumor Immunity
@sidichen @YaleMed @YaleCancer @NatImmunol
#NatureCancerPicks
--> Read here: https://t.co/EafB6qA9mN
These fascinating observations suggests new tumor dependencies that could lead to new therapeutic approaches for #glioblastoma and metastatic colonization to the brain. Don't miss! #NatureCancerPicks
https://t.co/yq64gcUmNX
https://t.co/YRNJyOTMiE
https://t.co/qA8kP21P1y
Doug Hanahan @EPFL_en shows how metastatic breast cancer cells co-opt NMDAR neuronal signalling to enable brain metastatic colonization @nature #NatureCancerPicks
Frank Winkler and Thomas Kuner @DKFZ @UniHeidelberg also found neurogliomal synapses located on tumor microtubes; these produce postsynaptic currents through AMPA glutamate receptors, forming electrically connected networks which favor tumor growth and invasion #NatureCancerPicks
First, @michelle_monje @humsav show that glioma cells interact with neurons through AMPA receptor synapses and non-synaptic potassium currents amplified by tumor-neuron gap junctions, promoting tumor progression @StanfordMed @Nature #NatureCancerPicks
๐ฌ Three reports today @nature show that tumor cells can engage in synaptic connections with neurons, and this reciprocal interaction impacts the way brain tumors progress #NatureCancerPicks #thread ๐๐๐
How does the tumor immune environment influence #TumorEvolution? @CharlesSwanton @NickyMcGranahan &co trace routes of immune evasion in NSCLC #TumorMicroenvironment #TumorImmunology #TRACERx #NatureCancerPicks https://t.co/6OFMsqu4mg
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