Top Tweets for #NephroNotes
🔥Our chapter on “Biomarkers for detecting nephrotoxicity due to immunosuppressant drugs” in textbook on BIOMARKERS IN KIDNEY TRANSPLANTATION
@drvivekkute
#NephroNotes #FOAMEd #MedEd
Hydration helps kidneys-but overhydration is not a detox.
#NephroNotes
💥Is there an entity called “Fatty Kidney Disease” ⁉️
⚡️Can kidneys too be obese?
Yes indeed ‼️
#NephroNotes #NephPearls #FOAMEd #MedEd
💥Let’s revise normal Lymph Node size at various anatomical sites
👉Important in CKD patients to rule out infection/AI disorders/malignancy
👉Important in post-transplant patients to rule out TID/PTLD
🔗 https://t.co/XGaYAMBf5K
#NephroNotes #NephPearls #FOAMed #MedEd #MedTwitter #MedX
💥Causes of Nocturia
♨️Alterations to AVP secretion
♨️Loss of concentrating ability of kidneys
♨️Alterations to urinary bladder urothelium
♨️Water homeostasis biosystem
♨️Circadian dysregulation
10.1016/j.urology.2019.07.020
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
💥For all #MedTwitter Residents
⁉️How do you measure BP❓
👉No talking
👉Back supported
👉Feet flat on floor
👉Quiet room
👉Empty bladder
👉Relax for 3-5 min
#Nephpearls #NephroNotes #FOAMed #MedTwitter #MedEd
💥Do you know⁉️
🔥Why Urine is brown in hematuria of upper urinary tract (Cola colored)?
🔆Prolonged contact of acidic urine with blood
👉Oxidation of heme pigment to Metheme derivative (Brown)
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
💥We all use modified Ponticelli regimen in MGN
⁉️Do you know how it’s different from original Ponticelli?
🔥Month 2/4/6:
🔆Ponticelli: Oral Chlorambucil @ 0.15-0.2 mg/kg/d
🔆mPonticelli: Oral cyclophosphamide @ 2 mg/kg/d
#NephroNotes #NephPearls #FOAMed #MedEd #MedTwitter
🌸CD19 vs CD20
👉Both eventually lost from terminally differentiating plasma cell
👉CD19 persist on Plasmablast/few plasma cell after CD20 expression lost
👉CD19+CD20− cell in lymphoid tissue provide immune memory
Pic-Sagepub
#NephroNotes #FOAMed #MedTwitter #MedEd #NephPearls
💥Did you know⁉️
1st metabolite identified in human urine was URIC ACID‼
🔥1776: Karl Scheele revealed that main component of bladder stone was URIC ACID (termed LITHIC ACID)
🔥UREA isolated by Fourcroy & Vauquelin 23 yrs later‼️
#NephroNotes #Nephpearls #FOAMed #MedX #MedEd
💥How do you predict small sized kidneys in child or adult with short stature❓
⚠️There can’t be a cut-off here
🔥kidney LPP (pole to pole length) is roughly equal to Lumbar vertebral length (L1-L3)‼️
#Nephpearls #NephroNotes #FOAMed #MedEd #MedX #NephX #MedicalStudents
💥How to differentiate Hyperfiltrating Secondary FSGS from Primary FSGS⁉️
🔥Slow⬆️proteinuria
🔥Absent Hypoalbuminemia/Edema even in massive proteinuria
🔥Enlarged Glomeruli
🔥Irregular podocyte effacement
🔥RAS🚫: Partial response
#NephroNotes #Nephpearls #FOAMed #MedX #MedEd
💥Pseudotubule formation in Podocytopathy
If tuft separated from Bowman capsule by circumscribing PEC
👇
Form "Empty slit"
👇
"Pseudotubule"
Did you know⁉️
🔆Persistent Pseudotubule in Obsolescent glomeruli s/o FSGS being primary‼️
#Nephpearls #NephroNotes #FOAMed #MedEd #MedX
💥How much Protein do you recommend to your HD/PD patients⁉️
♨️Nutritional recommendations in CKD
👉You can skip K restriction in PD‼️
👉🏻Ph- depend on protein intake
👉🏾Vit E supplementation: What’s your take?
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
💥CAPD as contraceptive⁉️
♨️In CKD5PD, Pregnancy 2-3X less common‼️
🔥Hypertonic dialysis fluid adversely effect ovum & its tranport to Fallopian tube
🔥Previous Peritonitis lead to adhesions & failure of fertilization/implantation
#NephroNotes #Nephpearls #FOAMed #MedTwitter
💥key mechanism of Pre-eclampsia⁉️
⚠️Don’t forget‼️
👉Loss of balance between angiogenic and anti-angiogenic factors
👉Disrupted pregnancy induced immunomodulation
Doi:10.1038/nrneph.2014.102
#NephroNotes #Nephpearls #FOAMed #MedEd #MedTwitter
💥Linear IgG staining on Direct Immunofluoroscence
⚠️Not always AntiGBM disease
🚫AntiGBM ab⁉️Look for👉
⚜️Post-Tx Alport
⚜️DKD
⚜️Elderly HTN Nephropathy
⚜️SLE
⚜️Fibrillary GN
⚜️Autopsy
⚜️Post-perfusion(cadaveric)
#Nephpearls #NephroNotes #FOAMed #MedEd #MedTwitter
💥Complements in PSGN
⬇️C3:90%
👉Alternate pathway activation by C3NeF autoab
👉Not always accompanied by⬇️ C4 as some ab/bac Ag stabilize alt pathway C3 convertase
⬇️C1 & C4:15-30%
👉Classical pathway activation by Protein H
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
💥In PIGN, why ⬇️C3 not always accompanied by ⬇️C4⁉️
👉Some antibody & bacterial Antigens able to stabilize alternate pathway C3 convertase
#NephroNotes #Nephpearls #FOAMed #MedTwitter #MedEd
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