Top Tweets for #OBpath
molar pregnancy!!! is does not get better than this!!
@leon_metlay @leon_metlay Would you call this a yolk sac remnant? (POC specimen, missed abortion) #placentapath #obpath
I think this is a good example of villous linear subtrophoblastic mineralization, a distinctive pattern that has been associated w/ congenital anomalies, Trisomy 21, anencephaly, & antenatal Bartter syndrome.
This case: cytogenetics = Trisomy 21
#obpath #placentapath
1st trimester missed abortion
What's being shown here? Any guesses on what the karyotype confirmed?
#placentapath #obpath
Example of villi with negative stromal cells but few/rare positive cytotrophoblast
Interested to see how many people have seen this discordant pattern! (3/3)
#obpath #placentapath
@leon_metlay @JasmineSteeleMD
#obpath - POC: morphologically looks like complete mole; ploidy analysis = diploid
p57 is a bit strange: villous stromal cells are uniformly negative, but a subset of villi have few p57+ cytotrophoblast
Per PMID: 30500280 - a few p57+ cells are OK. Is that your experience? (1/3)
#placentapath #obpath I have a favor to ask!
If you use a dissecting microscope to evaluate for villi, what's the make/model๐ฌ?
Either I don't know how to properly use the one in my lab, or it's the wrong kind ๐คทโโ๏ธ
Thank you!! ๐
@leon_metlay @JasmineSteeleMD @E_Heidi_Cheek
ISGyP 166.4 39 years. ย Hysterectomy for placenta accreta. ย Submucosal fibroid noted. Diagnosis: Inflammatory myofibroblastic tumour. ย ALK IHC and FISH positive. Inflammatory myofibroblastic tumor (IMT) is related to abnormalities in the ALK gene.
Intraplacental hepatic heterotopia
(benign, just a quirk of development!)
#placentapath #obpath #PathTwitter
Placentophiles!
Here's something incidental and fun. Ever seen one?
Answer posted below.
#placentapath #obpath #PathTwitter
Do you see what I see?
IUFD at 35 weeks, likely due to cord accident (true knot)
#placentapath #obpath
Hey #PathTwitter! I'm Jose Manuel Martin, an IMG from ๐ป๐ช and Research Fellow at @MGH_RI excited to be applying to #Pathology for this #Match2025 ๐ฌ. I have an interest in #GYN and #OBpath. I'm also a cinema enthusiast ๐ฝ๏ธ. Looking forward to connect with this great community!
POC, demise @ 7 weeks
Possible embryonic tissue or early umbilical cord?๐คทโโ๏ธ
#obpath #placentapath
#placentapath #obpath friends!
Full term placenta w/ obvious acute chorio in the membranes...
Does the fetal inflammatory response seem a bit odd in the chorionic plate vessels? Seems a bit more lymphohistiocytic-rich than usual.
@leon_metlay @JasmineSteeleMD
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