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Primary outcome: time from birth to medical readiness for discharge (ESC cohort, n=383). Symptom-based dosing: 9.18 days vs scheduled taper: 11.61 days. Adjusted mean ratio 0.79 (95% CI 0.65-0.96). That is a 2.3-day reduction. Statistically significant. #OPTimizeNOW #NeonatalOutcomes
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