Top Tweets for #PDB50structures
Inspired by the great #PDB50structures series @PDBeurope, the crystal structure of Cas9 bound to guide RNA and target DNA. The #CRISPR-Cas9 system is now used for gene editing and was adapted from a naturally occurring genome editing system in bacteria. https://t.co/6qMlWQRuN9
Our final #PDB50structures is a hint at the future of PDB structures. The pink region of this SMG1-8-9 kinase complex was modelled from a @DeepMind #AlphaFoldDB prediction, using low resolution EM and cross-linking data. View the structure at https://t.co/jJkNOhxdXB
Our 49th #PDB50structures is the iconic bacteriophage, a virus that infects bacteria - literally 'bacteria eater'. There are no structures of a full bacteriophage, but are full structures of the T4 phage capsid and baseplate: https://t.co/rxIx4bJhjj & https://t.co/w0Mmm9ckcq
Development of vaccines against the #covid19 spike protein, including identifying antibody interactions, is vital to combat the pandemic and new variants. There are now 150 #PDB50structures of COVID-19 spike proteins with antibodies. View them all: https://t.co/VcwPSzWNvp
Our 47th #PDB50structures is the photosynthetic reaction centre, the first high-resolution structure of a membrane protein. It earned Deisenhofer, Huber and Michel the 1988 Nobel Prize in Chemistry. View it at https://t.co/WhcfehNArh
βοΈHow about fetching the X,Y,Z coordinates of your protein structure with literally 3 lines of #Python code?
πMDTraj package can be used for this purpose.
#Bioinformatics #pythonlearning #pythonprogramming #PDB50structures #Biology
Emmanuelle Charpentier and Jennifer Doudna were awarded the 2020 Nobel Prize in Chemistry for their work on CRISPR-Cas9. This system has been adapted for use in gene editing and is our 46th #PDB50structures. View the structure at https://t.co/qv7xiIOkWc
ATP synthase is a molecular motor that uses a proton gradient across the membrane to power synthesis of ATP - the cell's energy currency. This 45th #PDB50structures earned John Walker the 1997 Nobel Prize in Chemistry. View it at https://t.co/QBZHvSiRC8
Our 44th #PDB50structures is p53, a tumor suppressor protein - mutations in p53 are found in most tumors. There are over 200 structures of Human p53, helping understand its function and how it binds DNA to induce expression. View them all at #PDBeKB: https://t.co/GswOr81ptJ
There are thousands of NMR #PDB50structures in the PDB, determining structures and conformations of small proteins/complexes. This video shows an ensemble of 20 conformations of a phospholamban pentamer by both solid and solution-state NMR: https://t.co/CCXVqs9OHA
Our 25th #PDB50structures is DNA gyrase, a topoisomerase which breaks and supercoils bacterial DNA, helping prevent 'knotting' and incorrect DNA topology. View the structure: https://t.co/AyCpSU9jgi
Pleasant to see our +APN-1607 PHF map & model highlighted by #PDB50structures. It is really a great encouragement for us to work harder on tau PET ligands with cryo-EM together with other techniques. Many thanks to @MichelGoed and @SjorsScheres for supports!
Our 42nd #PDB50structures are Tau protein fibrils from Alzheimer's patients, studied using cryoEM. This structure highlights the binding of fluorescent tracer molecule APN-1607: https://t.co/v8AnNpFzAA
Aspirin was first synthesised over 100 years ago - it's a derivative of salicylic acid used in herbal remedies for hundreds of years. Our 42nd #PDB50structures is the complex of aspirin with phospholipase A2, inhibiting inflammatory response: https://t.co/chpDgAln4m
Our 40th #PDB50structures is DNA Helicase, the complex responsible for unwinding the strands of the DNA double helix. This bacterial helicase structure contains a strand of DNA being pulled through the centre https://t.co/4lZgdsgWv7
The first virus structures were deposited to the PDB in the early 80s, yet there are now around 1000 full viral capsids in the PDB. Shown is the earliest example: Tomato bushy stunt virus by Harrison et al. https://t.co/t0tqDyEca7 #PDB50structures
One of the first protein structures solved was that of haemoglobin, earning Max Perutz a share of the 1962 Nobel Prize in Chemistry. This 38th #PDB50structures transports oxygen around our body through our bloodstream: https://t.co/Q5hvnzeWS1
Transfer RNA (tRNA) was the first non-protein structure in the PDB and our 37th #PDB50structures. There are now over 800 PDB entries containing tRNA - find them all at https://t.co/txCzoyTsL6
Our 36th #PDB50structures is cyclooxygenase (COX), which is a target for anti-inflammatory drugs (NSAIDs). This structure shows COX-2 bound to ibuprofen. View all Mouse COX-2 structures in #PDBeKB at https://t.co/WjU2HNp7UJ
Our 35th #PDB50structures is RNA polymerase, responsible for transcription of DNA to RNA. Roger Kornberg earned the 2006 Nobel Prize in Chemistry for his work on the complex and determination of the structure: https://t.co/1hqk1bew0u
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