Top Tweets for #PRION2019
Nice to see more prion scientists using @biorxivpreprint — new paper on protein turnover in prion-infected cells from Sina Ghaemmaghami's lab: https://t.co/4zzF8SzLFO which was a nice poster at #Prion2019 https://t.co/hdLe2vSunt
Is prion acumulation in the bone marrow the origin of prionhemia? 🧠💉🔬Interesting results presented by Dr. Olivier Andreoletti INRA-ENVT #PRION2019
Very proud to be involved in this huge collaborative effort - would love to hear any tips from anyone at #Prion2019 on replication and post-GWAS analysis going forward!
I presented findings from sCJD GWAS that involves pretty much all the major (non-Asian) centres that see patients (n=5100). Evidence for three new risk genes STX6, PDIA4 and GAL3ST1. #prion2019 thanks everyone for sending me samples
Here are my notes from days 2 & 3 and the posters at #Prion2019: https://t.co/hdLe2vSunt
We fly back to Boston tomorrow — sorry to miss the rest of this awesome event! It has been so good seeing everyone!
I presented findings from sCJD GWAS that involves pretty much all the major (non-Asian) centres that see patients (n=5100). Evidence for three new risk genes STX6, PDIA4 and GAL3ST1. #prion2019 thanks everyone for sending me samples
#prion2019 Andrew Thompson presented Nfl and Tau protein measurement in blood in a large patient sample from the London Cohort. Tau correlated with disease rate of change, Nfl with disease stage and as a proximity biomarker in those at risk
#prion2019 Sonia Vallabh presents efficacy data using Ionis ASOs, works surprisingly well very close to symptom onset. And biomarker development in at risk individuals - negative but for one +ve rtQuic elderly carrier of 200K in CSF
Want to learn more about animal prion diseases? Check out these two awesome #PRION2019 posters from Greenlee prion group postdocs, Najiba Mammadova (#242) and Eric Cassmann (#49).
#prion2019 andreoletti presents transmission of sporadic CJD strains. Generally, to cut a v long story short, his work confirms the standard neuropathological typing incl. mixed strains. Fantastic work v important.
#prion2019 Joel Watts presented convincing evidence of alpha synuclein “strains” documented by serial passage in mice, clinical and path phenotype, differing by salt and no salt preparation.
Jucker #prion2019 summarises where we are wrt amyloid seeding. He is investigating the characteristics of abeta seeds, incl. by titration, mechanisms of spread, durability and biomarkers. Fascinating time course of abeta seeding in Tg mice (it peaks early on! - like prions)
#Prion2019 attendees be sure to check out poster No. 224 by our fabulous Research Scientist Andrew Reidenbach, describing our efforts to find a PrPC ligand by NMR fragment screening. Spoiler alert: PrP is a really difficult target!
#prion2019 Haigh presented infection of cerebral human brain organoids with sporadic CJD prions. She showed a number of disease pathology characteristics, although many shared with aged controls
Dr. @FrancLlorens1 discusses the impact of new #CJD mouse models in #prion2019 meeting in Edmonton, Canada.
This morning we had the structure session of #prion2019 and for me not much has changed - one collaborative group strongly assert a beta-solenoid model for prions. Others question whether this is compatible with H/D exchange data and experience with 145stop amyloid
My slides from my #Prion2019 talk yesterday are now on SlideShare https://t.co/44jGuAANO4 Drop by poster No. 219 tonight if you have questions!
@francois_kroll @PRION2019 You can make comments and suggestions to @ThanosDim3 who is attending the conference #Prion2019 So proud of all the hard work delivered by @francois_kroll and @ThanosDim3
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