Top Tweets for #PathCorrelate
This week’s #PathCorrelate is lymph node metastases. Seen below is a hypercellular lymph node sample on the right of the image with abnormal carcinoma found within the same sample. This is representative of metastatic micropapillary carcinoma. From https://t.co/SvewBrDPA5.
12/12
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This week’s #PathCorrelate is Iron Deficiency Anemia. This is the most common cause of anemia and is due to a multitude of etiologies. Once iron deficiency anemia is diagnosed, further workup must be ordered to explore the underlying cause.
12/13
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This week’s #PathCorrelate is lymphocytosis, defined as an increase in peripheral lymphocytes >33% of circulating WBCs. This is a common abnormality seen in acute viral and chronic infections and neoplastic processes.
14/15
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This week’s #PathCorrelate is a deep vein thrombosis. Clinically, this usually presents as unilateral lower extremity edema with erythema and dull pain on dorsiflexion of the foot and compression of the calf.
13/14
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This week’s #PathCorrelate is an aortic dissection. Clinically, this has a wide variety of presentations/symptoms: Sudden ‘tearing’ pain of the anterior chest or back w/ variable blood pressure. Wide pulse pressure is common.
14/15
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This week’s #PathCorrelate is a myocardial infarction. Clinically, this has some stereotyped symptoms of substernal chest pain, left shoulder/jaw pain, dyspnea, and diaphoresis, but its presentation can be extremely variable.
14/15
Most commonly, this is due to a gallstone formed in the gallbladder and becomes stuck in the cystic duct.
On histology, we can see loss of mucosa, hemorrhage, and inflammatory cell infiltrate. See this demonstrated here from https://t.co/SvewBrDPA5.
#PathCorrelate
13/13
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This week’s #PathCorrelate is Acute Cholecystitis, which is inflammation of the gallbladder. This is typically presents with Right Upper Quadrant pain that is postprandial and colicky in nature.
12/13
On histology, we can see bridging septa of fibrous tissue with interspersed regenerative nodules of hepatocytes. Notably, the hepatic lobule organization is largely destroyed.
Different patterns of fibrosis are seen with each etiology
#PathCorrelate
15/15
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This week’s #PathCorrelate is cirrhosis. Chronic inflammation from prolonged toxin exposure (ethanol), hepatotropic infections, and/or metabolic disruption induces fibrotic changes.
14/15
On histology, we can see the differences in pathophysiology! Type I (A) has an autoimmune mechanism, which is reflected by dense inflammatory infiltrate, while Type II (B) shows amylin deposition due to overactive Beta cells with eventual burnout.
#PathCorrelate
15/15
Thanks for sticking around for another week! This week’s #PathCorrelate is Diabetes Mellitus, which affects nearly 11% of the U.S. population. Type I and II have extremely unique pathophysiologies, but both relate to the function of Beta cells in the endocrine pancreas.
14/15
On histology, we can expect to see hyper-cellular regions with epithelial and myoepithelial cells and hypo-cellular regions primarily composed of hyalinized stroma.
#PathCorrelate
15/15
Risk factors for hemorrhoids are: low fiber diets, constipation, straining at defecation, or conditions that produce increased pressure on these veins.
#PathCorrelate
16/16
Thanks for sticking around for another week! This week’s #PathCorrelate is Hemorrhoids. These are dilated mucosal and submucosal veins found in the anal canal.
15/16
This damage is a result of a maladaptive immune response. The diagnosis often requires pathologic and clinical correlation!
On histology, it is characterized by intraepithelial lymphocytes, villous atrophy, and crypt hyperplasia.
#PathCorrelate
https://t.co/4KwKwp202r
16/16
Thanks for sticking around for another week! This week’s #PathCorrelate is Celiac Disease. This is the pathologic damage to the duodenum and jejunum in response to gluten (a protein found in many grains).
15/16
A common presenting symptom is pain after meals. Risk factors include Helicobacter Pylori infection, excessive/prolonged NSAID use, and an imbalance of the local acidity within the stomach lumen.
#PathCorrelate
16/16
Thanks for sticking around for another week! This week’s #PathCorrelate is gastric ulcers. This is the pathological, focal loss of the mucosal layer of the stomach.
15/16
This pathology is associated with the atopic triad: asthma, atopic dermatitis, and allergic rhinitis.
On biopsy, note the marked number of eosinophils within the epithelial layer. These are pink cytoplasmic cells that we will cover in future tweetorials.
#PathCorrelate
17/17
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