Top Tweets for #ProTaC
Save this thread.
Protein degradation will be one of the most important
investment themes of the next decade.
The Roche-Nurix deal this week
put a $2.3B number on the platform.
That is just the beginning.
Follow @BioAlphaa for weekly coverage.
NFA. DYOR. #Biotech #PROTAC
🔬 新着リリース｜1,000種類以上の新規研究用分子を公開
本リリースでは、#腫瘍学 #神経科学 #免疫・炎症 #代謝疾患などの主要分野を強化し、創薬研究および基礎研究の幅広いニーズに対応します。
主な研究分野：
✔ #PROTAC による標的タンパク質分解
✔ RNA編集制御（#ADAR1）
✔ 神経炎症・自然免疫（TREM2、NLRP3）
✔ 炎症シグナル経路（PDE4B、IL-36R、LPAR1）
✔ 骨代謝制御（RANKL）
多くの化合物は、経口バイオアベイラビリティ、血液脳関門（#BBB）透過性、高い選択性、良好な薬物動態プロファイルなどの優れた特性を有し、標的検証、作用機序解析、初期創薬研究を強力にサポートします。
🔬 高品質なバイオアクティブ分子で、画期的な研究を支援します https://t.co/YH9RdGZbXM
#創薬研究 #神経炎症 #低分子化合物 #研究ツール #免疫学 #腫瘍学 #代謝研究 #ライフサイエンス #バイオテクノロジー
米国初のPROTAC承認。塩野義のコロナ予防薬「Xocova」やビーワンのBCL2阻害剤など、2026年5月にFDAが承認した新薬群。PROTACという新しい創薬モダリティの本格的な市場参入が始まる。 https://t.co/xvW3cRWptF #PROTAC #新薬承認 #FDA @Answers_News
🔥Hot Off the Press | Nb-PROTAC Enables Broad-Spectrum Anti-Influenza Breakthrough
#InfluenzaA viruses continue to pose a major global health challenge due to rapid mutation and frequent drug resistance. A new study introduces a nanobody-based #PROTAC (Nb-PROTAC) strategy that shifts antiviral therapy from functional inhibition to targeted viral protein degradation.
🚀By fusing NP-specific nanobodies with the VHL E3 ligase component, the system directly drives degradation of the highly conserved influenza nucleoprotein (NP), offering a novel antiviral modality.
✔️ Pan-subtype NP degradation across all 16 influenza A subtypes (H1–H16)
✔️ Strong inhibition of H1N1, H3N2, H5N1, H7N9, and H9N2 replication
✔️ In vivo AAV-LungM3 delivery achieved 90% (H1N1) and 80% (H5N1) survival in lethal models
✔️ Mechanistically involves the autophagy–lysosome pathway, with OPTN participation
Nb-PROTAC represents a modular and programmable antiviral platform with strong potential for broad-spectrum and next-generation infectious disease control.
MedChemExpress provides #Puromycin, #LY294002, and #MG132 to support this study, along with 5,000+ PROTAC-related reagents and one-stop services covering design, synthesis, optimization, and evaluation, empowering and accelerating your scientific research.
#NbPROTAC #TargetedProteinDegradation #AntiviralResearch #Influenza #DrugDiscovery #Biotechnology #Virology #ScienceNews #Biomedicine
A major milestone for #ProteinDegraders: the FDA approved Pfizer & Arvinas’ oral #PROTAC therapy vepdegestrant a month ahead of the expected date. We’re excited by this progress & continue to support development with high quality #biospecimens & services: https://t.co/0OxoEfbjRE
💊#FDA Approval Update | #Vepdegestrant (#Veppanu) approved for advanced/metastatic breast cancer
🔸A first-in-class #PROTAC that goes beyond inhibition, driving degradation of its target protein.
🚀A validation of an entirely new therapeutic modality.
🌟MedChemExpress offers vepdegestrant for research use only: https://t.co/aMjCngnPku
#BreastCancer #Biotech #Pharma #MedicinalChemistry #FDAApproval
💊#FDA Approval Update | #Vepdegestrant (#Veppanu) approved for advanced/metastatic breast cancer
🔸A first-in-class #PROTAC that goes beyond inhibition, driving degradation of its target protein.
🚀A validation of an entirely new therapeutic modality.
🌟MedChemExpress offers vepdegestrant for research use only: https://t.co/ORZIGTHLxF
#BreastCancer #Biotech #Pharma #MedicinalChemistry #FDAApproval
First ever #PROTAC @FDAOncology approval based on @Yale @YaleCancer dr Craig Crews lab discoveries for ER+ve metastatic breast cancer (Dr Crews work also led to approval of carfilzomib for #MMsm approval in 2012) https://t.co/RZHQhJzxCu
I am very happy to share our very first article on the #PROTAC discovery just out in @rsc_medchem !
https://t.co/FzEoDRxef1
#UkraineStands #terroruzziMustDie #ProteinDegradation
@EnamineLtd @KyivUniversity
The Dawn of Targeted Protein Degradation (TPD) in Oncology!
On May 1, 2026, the #FDA approved Vepdegestrant, the first-in-class PROTAC drug, for ESR1-mutated ER+/HER2- metastatic breast cancer.
#BreastCancer #Oncology #PROTAC #PrecisionMedicine #FDAApproval
$ARVN FDA approval
https://t.co/o22KYPe5v3
It‘s time to remove the question mark!
A huge congrats to @CraigMCrews, Ray Deshaies and the scientists @ArvinasInc.
1st FDA approval for a #PROTAC on May 1st 2026. A day to remember. Extra drinks at the Proxidrugs GRC in a few weeks!
The first #PROTAC protein degrader therapy is now approved by the U.S. FDA. Developed with @Pfizer, this heterobifunctional protein degrader is approved to treat adults with ER+/HER2-, ESR1-mutated advanced or metastatic #breastcancer, as detected by an FDA-authorized test, with disease progression following at least one line of endocrine therapy.
Read more: https://t.co/n6uE5XaQds
#proteindegradation
Happy to share that our paper “SE(3)-PROTACs: Geometric Deep Learning for PROTAC Degradation Prediction” has been accepted for publication in the Q1 journal Briefings in Bioinformatics.
#AI #DrugDiscovery #PROTAC #Bioinformatics #BioPharma
Ponzo et al (2026) Proximity Binding Assay for #PROTAC Ternary Complex Analysis. ACS Sens #TPD #biophys #DrugDesign #MedChem #cheminformatics #OpenAccess
https://t.co/amtitmYRpX
Our preprint on "Pro-GAT: Reconnecting Fragmented PROTACs Using a Graph Attention Transformer" is now available on bioRxiv.
Check it out: https://t.co/RUXxmbYae0
#AI #DrugDiscovery #PROTAC #ComputationalBiology #ProGAT #Pharma #Drugparadigm
Last Seen Hashtags on Sotwe
chav
Seen from United Kingdom
Teen #bikini
Seen from France
NYC
Seen from United States
女德调教
Seen from United States
JerseyShore
Seen from United States
反差婊射屏出轨ntr羞辱
Seen from United States
Selingkuh vcs
Seen from Indonesia
SelecciónMX
nolimit video.
Seen from Turkey
furryfandom
Seen from United States
Most Popular Users
Elon Musk 
@elonmusk
240.3M followers
Barack Obama
@barackobama
119.3M followers
Donald J. Trump
@realdonaldtrump
111.6M followers
Cristiano Ronaldo
@cristiano
109.6M followers
Narendra Modi
@narendramodi
106.9M followers
Rihanna
@rihanna
97.4M followers
NASA
@nasa
92.1M followers
Justin Bieber
@justinbieber
90.7M followers
KATY PERRY
@katyperry
87.2M followers
Taylor Swift
@taylorswift13
81M followers
Lady Gaga
@ladygaga
72.5M followers
Kim Kardashian
@kimkardashian
69.5M followers
Virat Kohli
@imvkohli
69.1M followers
YouTube
@youtube
68.6M followers
Bill Gates
@billgates
63.6M followers
The Ellen Show
@theellenshow
62.5M followers
CNN
@cnn
61.9M followers
Neymar Jr
@neymarjr
61.8M followers
X
@x
60.9M followers
Selena Gomez
@selenagomez
60.3M followers