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So, time to drop this on anyone who cares about Sonic lore. Ian Flynn canonized a made-up fan term for Maria's illness, which ended up overwriting the real-life disorder she was supposed to have. Maria actually had 先天性免疫不全症候群 —, or Primary Immunodeficiency Syndrome. It's a real genetic disorder. The term is right there, in Rouge's report "The Truth of 50 Years Ago," after "NIDS." NIDS was always an abbreviation that didn't stand for anything until fans, and later Archie, filled it in. "Neuro-immunodeficiency Disorder" is a nonexistent illness. After Archie, it was used in Sonic Chronicles (explicitly non-canon), and later Ian's Encyclospeedia. Ian finally had Shadow Generations say Maria "contracted" "Neuro-immunodeficiency Disorder" as a kid, solidifying it as "canon". Maekawa already confirmed the intent was that Maria lived on the ARK to stay away from Earth's pathogens. This is because Maria had a real autoimmune disorder she was born with, likely diagnosed as a baby. Now Maria has a made-up illness she contracted when she was old enough to remember Spagonia. Isn't that nice? #SonictheHedgehog #ShadowtheHedgehog